| Full name: single-strand-selective monofunctional uracil-DNA glycosylase 1 | Alias Symbol: UNG3|FDG|HMUDG | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 23583 | HGNC ID: HGNC:17148 | Ensembl Gene: ENSG00000123415 | OMIM ID: 607753 |
| Drug and gene relationship at DGIdb | |||
Expression of SMUG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMUG1 | 23583 | 223684_s_at | 0.0871 | 0.8417 | |
| GSE20347 | SMUG1 | 23583 | 218685_s_at | 0.1387 | 0.2314 | |
| GSE23400 | SMUG1 | 23583 | 218685_s_at | 0.0014 | 0.9802 | |
| GSE26886 | SMUG1 | 23583 | 223684_s_at | 0.0507 | 0.6765 | |
| GSE29001 | SMUG1 | 23583 | 218685_s_at | 0.2704 | 0.2264 | |
| GSE38129 | SMUG1 | 23583 | 218685_s_at | 0.2434 | 0.0193 | |
| GSE45670 | SMUG1 | 23583 | 223684_s_at | 0.2987 | 0.0235 | |
| GSE53622 | SMUG1 | 23583 | 42408 | -0.0051 | 0.9294 | |
| GSE53624 | SMUG1 | 23583 | 40650 | 0.2205 | 0.0068 | |
| GSE63941 | SMUG1 | 23583 | 223684_s_at | 0.8437 | 0.0344 | |
| GSE77861 | SMUG1 | 23583 | 223684_s_at | -0.0134 | 0.9332 | |
| GSE97050 | SMUG1 | 23583 | A_33_P3292794 | 0.1029 | 0.6673 | |
| SRP007169 | SMUG1 | 23583 | RNAseq | -0.6976 | 0.0980 | |
| SRP008496 | SMUG1 | 23583 | RNAseq | -0.6511 | 0.0080 | |
| SRP064894 | SMUG1 | 23583 | RNAseq | 0.1946 | 0.4732 | |
| SRP133303 | SMUG1 | 23583 | RNAseq | 0.2936 | 0.0509 | |
| SRP159526 | SMUG1 | 23583 | RNAseq | -0.0615 | 0.7237 | |
| SRP193095 | SMUG1 | 23583 | RNAseq | -0.1352 | 0.2853 | |
| SRP219564 | SMUG1 | 23583 | RNAseq | -0.1325 | 0.6775 | |
| TCGA | SMUG1 | 23583 | RNAseq | 0.0643 | 0.2650 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SMUG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMUG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMUG1 | 23583 | 4 | 1 | 25 | |
| GSE20123 | SMUG1 | 23583 | 4 | 1 | 25 | |
| GSE43470 | SMUG1 | 23583 | 3 | 0 | 40 | |
| GSE46452 | SMUG1 | 23583 | 7 | 1 | 51 | |
| GSE47630 | SMUG1 | 23583 | 10 | 2 | 28 | |
| GSE54993 | SMUG1 | 23583 | 0 | 5 | 65 | |
| GSE54994 | SMUG1 | 23583 | 4 | 1 | 48 | |
| GSE60625 | SMUG1 | 23583 | 0 | 0 | 11 | |
| GSE74703 | SMUG1 | 23583 | 3 | 0 | 33 | |
| GSE74704 | SMUG1 | 23583 | 3 | 1 | 16 | |
| TCGA | SMUG1 | 23583 | 15 | 11 | 70 |
Total number of gains: 53; Total number of losses: 23; Total Number of normals: 412.
Somatic mutations of SMUG1:
Generating mutation plots.
Highly correlated genes for SMUG1:
Showing top 20/58 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMUG1 | FBXO22 | 0.711832 | 3 | 0 | 3 |
| SMUG1 | E2F8 | 0.668408 | 3 | 0 | 3 |
| SMUG1 | POLR3G | 0.657991 | 3 | 0 | 3 |
| SMUG1 | VAMP8 | 0.649189 | 3 | 0 | 3 |
| SMUG1 | SH3RF1 | 0.647485 | 3 | 0 | 3 |
| SMUG1 | ABT1 | 0.624527 | 3 | 0 | 3 |
| SMUG1 | CORO2A | 0.62313 | 3 | 0 | 3 |
| SMUG1 | CLECL1 | 0.616749 | 3 | 0 | 3 |
| SMUG1 | KDF1 | 0.613653 | 3 | 0 | 3 |
| SMUG1 | SFT2D1 | 0.608985 | 5 | 0 | 4 |
| SMUG1 | BRI3BP | 0.605611 | 5 | 0 | 4 |
| SMUG1 | CDH1 | 0.605257 | 3 | 0 | 3 |
| SMUG1 | TBC1D7 | 0.603278 | 4 | 0 | 3 |
| SMUG1 | MAL2 | 0.594117 | 4 | 0 | 3 |
| SMUG1 | UBE2J2 | 0.590622 | 3 | 0 | 3 |
| SMUG1 | ERBB3 | 0.587322 | 3 | 0 | 3 |
| SMUG1 | DUS2 | 0.585273 | 4 | 0 | 3 |
| SMUG1 | FARSA | 0.576172 | 4 | 0 | 3 |
| SMUG1 | HES5 | 0.570387 | 3 | 0 | 3 |
| SMUG1 | SLC11A2 | 0.566213 | 4 | 0 | 3 |
For details and further investigation, click here
