| Full name: cyclin dependent kinase like 1 | Alias Symbol: KKIALRE | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 8814 | HGNC ID: HGNC:1781 | Ensembl Gene: ENSG00000100490 | OMIM ID: 603441 |
| Drug and gene relationship at DGIdb | |||
Expression of CDKL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDKL1 | 8814 | 235512_at | -0.1194 | 0.7858 | |
| GSE20347 | CDKL1 | 8814 | 207766_at | 0.0350 | 0.6419 | |
| GSE23400 | CDKL1 | 8814 | 207766_at | -0.0909 | 0.0001 | |
| GSE26886 | CDKL1 | 8814 | 235512_at | 0.8146 | 0.0072 | |
| GSE29001 | CDKL1 | 8814 | 207766_at | -0.0711 | 0.5008 | |
| GSE38129 | CDKL1 | 8814 | 207766_at | -0.0866 | 0.1187 | |
| GSE45670 | CDKL1 | 8814 | 235512_at | 0.2208 | 0.4456 | |
| GSE53622 | CDKL1 | 8814 | 146563 | -0.3239 | 0.0035 | |
| GSE53624 | CDKL1 | 8814 | 146563 | 0.1874 | 0.0679 | |
| GSE63941 | CDKL1 | 8814 | 235512_at | -0.7187 | 0.3104 | |
| GSE77861 | CDKL1 | 8814 | 207766_at | -0.1591 | 0.0666 | |
| GSE97050 | CDKL1 | 8814 | A_23_P99741 | 0.1706 | 0.4342 | |
| SRP007169 | CDKL1 | 8814 | RNAseq | 0.1684 | 0.7327 | |
| SRP008496 | CDKL1 | 8814 | RNAseq | -0.1727 | 0.6229 | |
| SRP064894 | CDKL1 | 8814 | RNAseq | -0.2157 | 0.3526 | |
| SRP133303 | CDKL1 | 8814 | RNAseq | -0.1964 | 0.1563 | |
| SRP159526 | CDKL1 | 8814 | RNAseq | -0.5038 | 0.0252 | |
| SRP193095 | CDKL1 | 8814 | RNAseq | -0.1933 | 0.0946 | |
| SRP219564 | CDKL1 | 8814 | RNAseq | 0.3954 | 0.2882 | |
| TCGA | CDKL1 | 8814 | RNAseq | 0.0495 | 0.7507 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDKL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDKL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDKL1 | 8814 | 8 | 2 | 20 | |
| GSE20123 | CDKL1 | 8814 | 8 | 3 | 19 | |
| GSE43470 | CDKL1 | 8814 | 9 | 1 | 33 | |
| GSE46452 | CDKL1 | 8814 | 16 | 3 | 40 | |
| GSE47630 | CDKL1 | 8814 | 11 | 10 | 19 | |
| GSE54993 | CDKL1 | 8814 | 3 | 9 | 58 | |
| GSE54994 | CDKL1 | 8814 | 20 | 4 | 29 | |
| GSE60625 | CDKL1 | 8814 | 0 | 2 | 9 | |
| GSE74703 | CDKL1 | 8814 | 8 | 1 | 27 | |
| GSE74704 | CDKL1 | 8814 | 3 | 2 | 15 | |
| TCGA | CDKL1 | 8814 | 34 | 13 | 49 |
Total number of gains: 120; Total number of losses: 50; Total Number of normals: 318.
Somatic mutations of CDKL1:
Generating mutation plots.
Highly correlated genes for CDKL1:
Showing top 20/93 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDKL1 | SETD2 | 0.776098 | 3 | 0 | 3 |
| CDKL1 | FDXACB1 | 0.769607 | 3 | 0 | 3 |
| CDKL1 | RABGAP1L | 0.756343 | 3 | 0 | 3 |
| CDKL1 | ZACN | 0.746723 | 3 | 0 | 3 |
| CDKL1 | RINT1 | 0.736436 | 3 | 0 | 3 |
| CDKL1 | NUDT9 | 0.734162 | 3 | 0 | 3 |
| CDKL1 | PEX3 | 0.731114 | 3 | 0 | 3 |
| CDKL1 | LZIC | 0.730186 | 3 | 0 | 3 |
| CDKL1 | PRRT3 | 0.691844 | 3 | 0 | 3 |
| CDKL1 | RBM4 | 0.6918 | 3 | 0 | 3 |
| CDKL1 | C9orf85 | 0.686404 | 3 | 0 | 3 |
| CDKL1 | ATMIN | 0.685564 | 3 | 0 | 3 |
| CDKL1 | ZRANB1 | 0.670935 | 3 | 0 | 3 |
| CDKL1 | SNRNP35 | 0.661122 | 4 | 0 | 3 |
| CDKL1 | UBE2E2 | 0.65324 | 3 | 0 | 3 |
| CDKL1 | ZNF485 | 0.647062 | 3 | 0 | 3 |
| CDKL1 | ATF7 | 0.646852 | 4 | 0 | 4 |
| CDKL1 | MTA2 | 0.646332 | 4 | 0 | 4 |
| CDKL1 | RNFT1 | 0.643039 | 4 | 0 | 3 |
| CDKL1 | NDUFA13 | 0.6391 | 3 | 0 | 3 |
For details and further investigation, click here
