| Full name: RAD50 interactor 1 | Alias Symbol: FLJ11785|RINT-1 | ||
| Type: protein-coding gene | Cytoband: 7q22.3 | ||
| Entrez ID: 60561 | HGNC ID: HGNC:21876 | Ensembl Gene: ENSG00000135249 | OMIM ID: 610089 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RINT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RINT1 | 60561 | 218598_at | -0.2218 | 0.6986 | |
| GSE20347 | RINT1 | 60561 | 218598_at | 0.0227 | 0.8937 | |
| GSE23400 | RINT1 | 60561 | 218598_at | -0.0684 | 0.1927 | |
| GSE26886 | RINT1 | 60561 | 218598_at | -0.1755 | 0.5076 | |
| GSE29001 | RINT1 | 60561 | 218598_at | -0.4413 | 0.3360 | |
| GSE38129 | RINT1 | 60561 | 218598_at | 0.1940 | 0.2637 | |
| GSE45670 | RINT1 | 60561 | 218598_at | -0.0833 | 0.6999 | |
| GSE53622 | RINT1 | 60561 | 112659 | 0.0158 | 0.9098 | |
| GSE53624 | RINT1 | 60561 | 112659 | -0.2994 | 0.0000 | |
| GSE63941 | RINT1 | 60561 | 218598_at | -0.7058 | 0.1485 | |
| GSE77861 | RINT1 | 60561 | 218598_at | -0.6326 | 0.0993 | |
| GSE97050 | RINT1 | 60561 | A_23_P59677 | 0.1439 | 0.7367 | |
| SRP007169 | RINT1 | 60561 | RNAseq | -1.6616 | 0.0000 | |
| SRP008496 | RINT1 | 60561 | RNAseq | -1.5288 | 0.0000 | |
| SRP064894 | RINT1 | 60561 | RNAseq | -0.5486 | 0.0097 | |
| SRP133303 | RINT1 | 60561 | RNAseq | -0.1447 | 0.2261 | |
| SRP159526 | RINT1 | 60561 | RNAseq | -0.3577 | 0.2052 | |
| SRP193095 | RINT1 | 60561 | RNAseq | -0.2082 | 0.1412 | |
| SRP219564 | RINT1 | 60561 | RNAseq | -0.1791 | 0.6561 | |
| TCGA | RINT1 | 60561 | RNAseq | 0.0677 | 0.2240 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by RINT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RINT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RINT1 | 60561 | 13 | 0 | 17 | |
| GSE20123 | RINT1 | 60561 | 13 | 0 | 17 | |
| GSE43470 | RINT1 | 60561 | 7 | 1 | 35 | |
| GSE46452 | RINT1 | 60561 | 10 | 1 | 48 | |
| GSE47630 | RINT1 | 60561 | 8 | 3 | 29 | |
| GSE54993 | RINT1 | 60561 | 2 | 9 | 59 | |
| GSE54994 | RINT1 | 60561 | 15 | 3 | 35 | |
| GSE60625 | RINT1 | 60561 | 0 | 0 | 11 | |
| GSE74703 | RINT1 | 60561 | 7 | 1 | 28 | |
| GSE74704 | RINT1 | 60561 | 8 | 0 | 12 | |
| TCGA | RINT1 | 60561 | 54 | 7 | 35 |
Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.
Somatic mutations of RINT1:
Generating mutation plots.
Highly correlated genes for RINT1:
Showing top 20/587 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RINT1 | HPS5 | 0.779206 | 3 | 0 | 3 |
| RINT1 | GPBP1 | 0.760902 | 3 | 0 | 3 |
| RINT1 | SCAMP1 | 0.747345 | 3 | 0 | 3 |
| RINT1 | NCKAP1 | 0.746085 | 4 | 0 | 4 |
| RINT1 | SS18 | 0.743535 | 5 | 0 | 5 |
| RINT1 | CDKL1 | 0.736436 | 3 | 0 | 3 |
| RINT1 | SUFU | 0.732817 | 3 | 0 | 3 |
| RINT1 | RASSF5 | 0.728828 | 3 | 0 | 3 |
| RINT1 | IL10RB | 0.72171 | 5 | 0 | 4 |
| RINT1 | INTS12 | 0.720585 | 3 | 0 | 3 |
| RINT1 | TXNDC17 | 0.706749 | 3 | 0 | 3 |
| RINT1 | INPP1 | 0.705099 | 3 | 0 | 3 |
| RINT1 | MAPK6 | 0.696166 | 4 | 0 | 3 |
| RINT1 | CYB561 | 0.694862 | 5 | 0 | 5 |
| RINT1 | ECHDC1 | 0.692482 | 3 | 0 | 3 |
| RINT1 | ZNF273 | 0.691663 | 5 | 0 | 5 |
| RINT1 | FAM122A | 0.688214 | 3 | 0 | 3 |
| RINT1 | CPPED1 | 0.6868 | 4 | 0 | 4 |
| RINT1 | WIPI2 | 0.686031 | 3 | 0 | 3 |
| RINT1 | ANKRD37 | 0.685226 | 3 | 0 | 3 |
For details and further investigation, click here
