| Full name: Down syndrome critical region 4 | Alias Symbol: DCRB | ||
| Type: non-coding RNA | Cytoband: 21q22.13 | ||
| Entrez ID: 10281 | HGNC ID: HGNC:3045 | Ensembl Gene: ENSG00000184029 | OMIM ID: 604829 |
| Drug and gene relationship at DGIdb | |||
Expression of DSCR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSCR4 | 10281 | 207258_at | 0.0473 | 0.8724 | |
| GSE20347 | DSCR4 | 10281 | 207258_at | -0.0274 | 0.7670 | |
| GSE23400 | DSCR4 | 10281 | 207258_at | -0.2048 | 0.0002 | |
| GSE26886 | DSCR4 | 10281 | 207258_at | -0.2518 | 0.0224 | |
| GSE29001 | DSCR4 | 10281 | 207258_at | -0.3389 | 0.1609 | |
| GSE38129 | DSCR4 | 10281 | 207258_at | -0.1685 | 0.0289 | |
| GSE45670 | DSCR4 | 10281 | 207258_at | 0.0673 | 0.5705 | |
| GSE53622 | DSCR4 | 10281 | 53012 | 0.2277 | 0.0162 | |
| GSE53624 | DSCR4 | 10281 | 97633 | 0.5566 | 0.0000 | |
| GSE63941 | DSCR4 | 10281 | 207258_at | 0.1234 | 0.5001 | |
| GSE77861 | DSCR4 | 10281 | 207258_at | -0.1077 | 0.2794 | |
| TCGA | DSCR4 | 10281 | RNAseq | 2.9180 | 0.3103 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DSCR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSCR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSCR4 | 10281 | 2 | 8 | 20 | |
| GSE20123 | DSCR4 | 10281 | 2 | 9 | 19 | |
| GSE43470 | DSCR4 | 10281 | 1 | 11 | 31 | |
| GSE46452 | DSCR4 | 10281 | 1 | 21 | 37 | |
| GSE47630 | DSCR4 | 10281 | 6 | 17 | 17 | |
| GSE54993 | DSCR4 | 10281 | 8 | 1 | 61 | |
| GSE54994 | DSCR4 | 10281 | 3 | 9 | 41 | |
| GSE60625 | DSCR4 | 10281 | 0 | 0 | 11 | |
| GSE74703 | DSCR4 | 10281 | 1 | 8 | 27 | |
| GSE74704 | DSCR4 | 10281 | 1 | 6 | 13 | |
| TCGA | DSCR4 | 10281 | 8 | 42 | 46 |
Total number of gains: 33; Total number of losses: 132; Total Number of normals: 323.
Somatic mutations of DSCR4:
Generating mutation plots.
Highly correlated genes for DSCR4:
Showing top 20/815 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSCR4 | HAND1 | 0.71522 | 4 | 0 | 4 |
| DSCR4 | TUB | 0.707352 | 4 | 0 | 4 |
| DSCR4 | IL9R | 0.693509 | 4 | 0 | 4 |
| DSCR4 | MUC5AC | 0.692685 | 5 | 0 | 5 |
| DSCR4 | ATXN8OS | 0.688737 | 4 | 0 | 4 |
| DSCR4 | CYP2D6 | 0.684359 | 6 | 0 | 6 |
| DSCR4 | HPX | 0.684162 | 5 | 0 | 4 |
| DSCR4 | PRODH2 | 0.683369 | 5 | 0 | 5 |
| DSCR4 | HHLA1 | 0.676927 | 5 | 0 | 4 |
| DSCR4 | SYT13 | 0.674007 | 4 | 0 | 4 |
| DSCR4 | ANXA2 | 0.671643 | 3 | 0 | 3 |
| DSCR4 | TNFSF8 | 0.671155 | 3 | 0 | 3 |
| DSCR4 | GJB4 | 0.671105 | 5 | 0 | 4 |
| DSCR4 | IL18BP | 0.667753 | 5 | 0 | 5 |
| DSCR4 | ASCL3 | 0.665297 | 6 | 0 | 5 |
| DSCR4 | CHD2 | 0.66425 | 3 | 0 | 3 |
| DSCR4 | CYP11B1 | 0.662861 | 4 | 0 | 4 |
| DSCR4 | IFNA4 | 0.660469 | 4 | 0 | 4 |
| DSCR4 | CYP2A7 | 0.659843 | 5 | 0 | 4 |
| DSCR4 | TRH | 0.658488 | 4 | 0 | 4 |
For details and further investigation, click here
