| Full name: eukaryotic translation initiation factor 2B subunit alpha | Alias Symbol: EIF-2Balpha|EIF-2B|EIF2BA | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 1967 | HGNC ID: HGNC:3257 | Ensembl Gene: ENSG00000111361 | OMIM ID: 606686 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EIF2B1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2B1 | 1967 | 201632_at | -0.0393 | 0.9404 | |
| GSE20347 | EIF2B1 | 1967 | 201632_at | -0.0486 | 0.8006 | |
| GSE23400 | EIF2B1 | 1967 | 201632_at | 0.1811 | 0.0011 | |
| GSE26886 | EIF2B1 | 1967 | 201632_at | -0.3515 | 0.0644 | |
| GSE29001 | EIF2B1 | 1967 | 201632_at | -0.0071 | 0.9795 | |
| GSE38129 | EIF2B1 | 1967 | 201632_at | -0.0101 | 0.9413 | |
| GSE45670 | EIF2B1 | 1967 | 201632_at | 0.0399 | 0.7241 | |
| GSE53622 | EIF2B1 | 1967 | 5504 | -0.0112 | 0.8522 | |
| GSE53624 | EIF2B1 | 1967 | 5504 | 0.1363 | 0.0083 | |
| GSE63941 | EIF2B1 | 1967 | 201632_at | 0.0818 | 0.8012 | |
| GSE77861 | EIF2B1 | 1967 | 201632_at | -0.1141 | 0.5765 | |
| GSE97050 | EIF2B1 | 1967 | A_23_P105313 | 0.1699 | 0.4516 | |
| SRP007169 | EIF2B1 | 1967 | RNAseq | 0.0849 | 0.8148 | |
| SRP008496 | EIF2B1 | 1967 | RNAseq | -0.1382 | 0.5833 | |
| SRP064894 | EIF2B1 | 1967 | RNAseq | -0.0434 | 0.6268 | |
| SRP133303 | EIF2B1 | 1967 | RNAseq | -0.0512 | 0.6915 | |
| SRP159526 | EIF2B1 | 1967 | RNAseq | -0.0338 | 0.8346 | |
| SRP193095 | EIF2B1 | 1967 | RNAseq | -0.1142 | 0.1959 | |
| SRP219564 | EIF2B1 | 1967 | RNAseq | -0.2179 | 0.3066 | |
| TCGA | EIF2B1 | 1967 | RNAseq | 0.1050 | 0.0322 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2B1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2B1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2B1 | 1967 | 5 | 5 | 20 | |
| GSE20123 | EIF2B1 | 1967 | 5 | 5 | 20 | |
| GSE43470 | EIF2B1 | 1967 | 2 | 1 | 40 | |
| GSE46452 | EIF2B1 | 1967 | 9 | 1 | 49 | |
| GSE47630 | EIF2B1 | 1967 | 9 | 3 | 28 | |
| GSE54993 | EIF2B1 | 1967 | 0 | 5 | 65 | |
| GSE54994 | EIF2B1 | 1967 | 4 | 8 | 41 | |
| GSE60625 | EIF2B1 | 1967 | 0 | 0 | 11 | |
| GSE74703 | EIF2B1 | 1967 | 2 | 0 | 34 | |
| GSE74704 | EIF2B1 | 1967 | 3 | 3 | 14 | |
| TCGA | EIF2B1 | 1967 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 42; Total Number of normals: 386.
Somatic mutations of EIF2B1:
Generating mutation plots.
Highly correlated genes for EIF2B1:
Showing top 20/565 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2B1 | CHCHD6 | 0.761489 | 3 | 0 | 3 |
| EIF2B1 | ZNF436 | 0.748432 | 3 | 0 | 3 |
| EIF2B1 | FAM122B | 0.73835 | 3 | 0 | 3 |
| EIF2B1 | SOS2 | 0.736484 | 3 | 0 | 3 |
| EIF2B1 | PRKAB1 | 0.734071 | 3 | 0 | 3 |
| EIF2B1 | PANK1 | 0.726729 | 3 | 0 | 3 |
| EIF2B1 | VPS26A | 0.72553 | 4 | 0 | 4 |
| EIF2B1 | CENPC | 0.72453 | 3 | 0 | 3 |
| EIF2B1 | PIK3CB | 0.722331 | 4 | 0 | 3 |
| EIF2B1 | PSEN1 | 0.721965 | 4 | 0 | 4 |
| EIF2B1 | ANKRD28 | 0.721664 | 3 | 0 | 3 |
| EIF2B1 | GOLGA7 | 0.717542 | 4 | 0 | 4 |
| EIF2B1 | FAM32A | 0.715395 | 3 | 0 | 3 |
| EIF2B1 | NIPAL3 | 0.713886 | 3 | 0 | 3 |
| EIF2B1 | MCCC2 | 0.713543 | 3 | 0 | 3 |
| EIF2B1 | CCNY | 0.712188 | 3 | 0 | 3 |
| EIF2B1 | LMBRD2 | 0.71205 | 3 | 0 | 3 |
| EIF2B1 | ZNF317 | 0.705923 | 4 | 0 | 4 |
| EIF2B1 | TRAPPC8 | 0.704676 | 4 | 0 | 3 |
| EIF2B1 | UBE3B | 0.703232 | 3 | 0 | 3 |
For details and further investigation, click here
