| Full name: queuine tRNA-ribosyltransferase catalytic subunit 1 | Alias Symbol: TGT | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 81890 | HGNC ID: HGNC:23797 | Ensembl Gene: ENSG00000213339 | OMIM ID: 609615 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of QTRT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | QTRT1 | 81890 | 221270_s_at | 0.1324 | 0.7946 | |
| GSE20347 | QTRT1 | 81890 | 221270_s_at | 0.2733 | 0.0575 | |
| GSE23400 | QTRT1 | 81890 | 221270_s_at | 0.2646 | 0.0001 | |
| GSE26886 | QTRT1 | 81890 | 221270_s_at | 0.1347 | 0.5381 | |
| GSE29001 | QTRT1 | 81890 | 221270_s_at | 0.3178 | 0.3705 | |
| GSE38129 | QTRT1 | 81890 | 221270_s_at | 0.3389 | 0.0188 | |
| GSE45670 | QTRT1 | 81890 | 221270_s_at | 0.2232 | 0.1664 | |
| GSE53622 | QTRT1 | 81890 | 2175 | 0.0501 | 0.6620 | |
| GSE53624 | QTRT1 | 81890 | 2175 | 0.4166 | 0.0000 | |
| GSE63941 | QTRT1 | 81890 | 221270_s_at | 1.2643 | 0.0047 | |
| GSE77861 | QTRT1 | 81890 | 221270_s_at | 0.5599 | 0.0280 | |
| GSE97050 | QTRT1 | 81890 | A_24_P96234 | 0.3148 | 0.2645 | |
| SRP007169 | QTRT1 | 81890 | RNAseq | 0.4703 | 0.3311 | |
| SRP008496 | QTRT1 | 81890 | RNAseq | 0.6807 | 0.0643 | |
| SRP064894 | QTRT1 | 81890 | RNAseq | 0.7490 | 0.0101 | |
| SRP133303 | QTRT1 | 81890 | RNAseq | -0.1639 | 0.3832 | |
| SRP159526 | QTRT1 | 81890 | RNAseq | 0.1722 | 0.6636 | |
| SRP193095 | QTRT1 | 81890 | RNAseq | 0.2530 | 0.0240 | |
| SRP219564 | QTRT1 | 81890 | RNAseq | 0.9258 | 0.0945 | |
| TCGA | QTRT1 | 81890 | RNAseq | 0.1529 | 0.0098 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by QTRT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of QTRT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | QTRT1 | 81890 | 4 | 3 | 23 | |
| GSE20123 | QTRT1 | 81890 | 3 | 1 | 26 | |
| GSE43470 | QTRT1 | 81890 | 3 | 6 | 34 | |
| GSE46452 | QTRT1 | 81890 | 47 | 1 | 11 | |
| GSE47630 | QTRT1 | 81890 | 4 | 7 | 29 | |
| GSE54993 | QTRT1 | 81890 | 16 | 3 | 51 | |
| GSE54994 | QTRT1 | 81890 | 6 | 13 | 34 | |
| GSE60625 | QTRT1 | 81890 | 9 | 0 | 2 | |
| GSE74703 | QTRT1 | 81890 | 3 | 4 | 29 | |
| GSE74704 | QTRT1 | 81890 | 0 | 1 | 19 | |
| TCGA | QTRT1 | 81890 | 15 | 14 | 67 |
Total number of gains: 110; Total number of losses: 53; Total Number of normals: 325.
Somatic mutations of QTRT1:
Generating mutation plots.
Highly correlated genes for QTRT1:
Showing top 20/934 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| QTRT1 | ZNF766 | 0.791157 | 3 | 0 | 3 |
| QTRT1 | TP53I13 | 0.787165 | 3 | 0 | 3 |
| QTRT1 | ZNF496 | 0.778812 | 3 | 0 | 3 |
| QTRT1 | SOX13 | 0.777879 | 3 | 0 | 3 |
| QTRT1 | NUB1 | 0.772931 | 3 | 0 | 3 |
| QTRT1 | MCMBP | 0.767632 | 3 | 0 | 3 |
| QTRT1 | CHCHD6 | 0.764522 | 5 | 0 | 5 |
| QTRT1 | GLYR1 | 0.745879 | 3 | 0 | 3 |
| QTRT1 | ELOF1 | 0.745473 | 7 | 0 | 7 |
| QTRT1 | DYRK2 | 0.735398 | 4 | 0 | 4 |
| QTRT1 | ZFYVE9 | 0.735335 | 3 | 0 | 3 |
| QTRT1 | MRI1 | 0.728427 | 4 | 0 | 4 |
| QTRT1 | KLHL11 | 0.725613 | 3 | 0 | 3 |
| QTRT1 | SNRPN | 0.723411 | 3 | 0 | 3 |
| QTRT1 | AKT1S1 | 0.720287 | 4 | 0 | 3 |
| QTRT1 | STRN4 | 0.709315 | 3 | 0 | 3 |
| QTRT1 | NAB2 | 0.708967 | 4 | 0 | 4 |
| QTRT1 | B9D2 | 0.705876 | 4 | 0 | 4 |
| QTRT1 | ANKRD11 | 0.704607 | 3 | 0 | 3 |
| QTRT1 | C1orf122 | 0.702012 | 3 | 0 | 3 |
For details and further investigation, click here
