Full name: C-X-C motif chemokine ligand 3	Alias Symbol: SCYB3|GROg|MIP-2b|CINC-2b
Type: protein-coding gene	Cytoband: 4q13.3
Entrez ID: 2921	HGNC ID: HGNC:4604	Ensembl Gene: ENSG00000163734	OMIM ID: 139111
Drug and gene relationship at DGIdb

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CXCL3 involved pathways:

KEGG pathway	Description	View
hsa04062	Chemokine signaling pathway	View
hsa05134	Legionellosis	View

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Expression of CXCL3:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CXCL3	2921	207850_at	1.2262	0.4631	Show
GSE20347	CXCL3	2921	207850_at	0.2476	0.1709	Show
GSE23400	CXCL3	2921	207850_at	0.1231	0.0943	Show
GSE26886	CXCL3	2921	207850_at	0.6502	0.1992	Show
GSE29001	CXCL3	2921	207850_at	0.4728	0.1408	Show
GSE38129	CXCL3	2921	207850_at	0.3025	0.3001	Show
GSE45670	CXCL3	2921	207850_at	1.4817	0.0033	Show
GSE53622	CXCL3	2921	79411	1.0794	0.0000	Show
GSE53624	CXCL3	2921	79411	0.8118	0.0000	Show
GSE63941	CXCL3	2921	207850_at	-0.7808	0.5874	Show
GSE77861	CXCL3	2921	207850_at	0.5233	0.0594	Show
GSE97050	CXCL3	2921	A_24_P183150	1.1093	0.0888	Show
SRP133303	CXCL3	2921	RNAseq	2.2548	0.0001	Show
SRP159526	CXCL3	2921	RNAseq	2.2681	0.0004	Show
SRP193095	CXCL3	2921	RNAseq	2.1494	0.0000	Show
SRP219564	CXCL3	2921	RNAseq	2.0660	0.0738	Show
TCGA	CXCL3	2921	RNAseq	0.1733	0.5653	Show

Upregulated datasets: 5; Downregulated datasets: 0.  Download Data

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Survival by CXCL3 expression:

 

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Copy number change of CXCL3:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CXCL3	2921	2	9	19	Show
GSE20123	CXCL3	2921	2	9	19	Show
GSE43470	CXCL3	2921	0	13	30	Show
GSE46452	CXCL3	2921	3	34	22	Show
GSE47630	CXCL3	2921	1	19	20	Show
GSE54993	CXCL3	2921	7	0	63	Show
GSE54994	CXCL3	2921	1	9	43	Show
GSE60625	CXCL3	2921	0	0	11	Show
GSE74703	CXCL3	2921	0	11	25	Show
GSE74704	CXCL3	2921	2	5	13	Show
TCGA	CXCL3	2921	19	28	49	Show

Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.  Download Data

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Somatic mutations of CXCL3:

 

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Highly correlated genes for CXCL3:

 

Showing top 20/680 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CXCL3	CXCL2	0.78658	12	0	12
CXCL3	NCOA7	0.769888	3	0	3
CXCL3	SLC6A15	0.754333	4	0	4
CXCL3	CXCR4	0.745922	3	0	3
CXCL3	FOXC2	0.743929	3	0	3
CXCL3	SPRED1	0.743669	4	0	3
CXCL3	DDX11	0.737717	3	0	3
CXCL3	CXCL5	0.726054	10	0	8
CXCL3	ETV5	0.722575	4	0	4
CXCL3	SPRY4-IT1	0.713123	3	0	3
CXCL3	CHD2	0.708793	3	0	3
CXCL3	NR5A2	0.70525	3	0	3
CXCL3	SOX18	0.705049	3	0	3
CXCL3	C6orf141	0.704469	3	0	3
CXCL3	C9orf64	0.699821	3	0	3
CXCL3	ARL5B	0.693015	4	0	3
CXCL3	ALPK2	0.684913	3	0	3
CXCL3	DDX21	0.683192	4	0	3
CXCL3	NEDD9	0.682887	4	0	3
CXCL3	IL1B	0.680512	11	0	9

For details and further investigation, click here