PRKCQ

 

Full name: protein kinase C theta Alias Symbol: 
Type: protein-coding gene Cytoband: 10p15.1
Entrez ID: 5588 HGNC ID: HGNC:9410 Ensembl Gene: ENSG00000065675 OMIM ID: 600448
Drug and gene relationship at DGIdb

 

PRKCQ involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04530Tight junction
hsa04660T cell receptor signaling pathway
hsa04750Inflammatory mediator regulation of TRP channels
hsa04920Adipocytokine signaling pathway
hsa04931Insulin resistance
hsa05162Measles

 

Expression of PRKCQ:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCQ 5588 210038_at 0.0459 0.9772
GSE20347 PRKCQ 5588 210038_at -0.1672 0.3503
GSE23400 PRKCQ 5588 210039_s_at -0.2015 0.0035
GSE26886 PRKCQ 5588 210038_at 0.6511 0.0877
GSE29001 PRKCQ 5588 210038_at 0.1216 0.6883
GSE38129 PRKCQ 5588 210038_at -0.5447 0.0042
GSE45670 PRKCQ 5588 210038_at -0.0064 0.9883
GSE53622 PRKCQ 5588 64141 -0.0572 0.7735
GSE53624 PRKCQ 5588 64141 0.1037 0.4908
GSE63941 PRKCQ 5588 210038_at 1.2073 0.1313
GSE77861 PRKCQ 5588 210039_s_at -0.0400 0.7432
GSE97050 PRKCQ 5588 A_23_P1374 0.1430 0.6965
SRP064894 PRKCQ 5588 RNAseq 0.2637 0.4053
SRP133303 PRKCQ 5588 RNAseq -0.7418 0.0145
SRP159526 PRKCQ 5588 RNAseq -0.8154 0.0985
SRP193095 PRKCQ 5588 RNAseq 0.3370 0.2132
SRP219564 PRKCQ 5588 RNAseq 0.0634 0.9253
TCGA PRKCQ 5588 RNAseq 0.1549 0.5975

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PRKCQ expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCQ:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCQ 5588 5 8 17
GSE20123 PRKCQ 5588 5 7 18
GSE43470 PRKCQ 5588 3 6 34
GSE46452 PRKCQ 5588 2 14 43
GSE47630 PRKCQ 5588 5 15 20
GSE54993 PRKCQ 5588 11 0 59
GSE54994 PRKCQ 5588 4 10 39
GSE60625 PRKCQ 5588 0 0 11
GSE74703 PRKCQ 5588 2 4 30
GSE74704 PRKCQ 5588 1 6 13
TCGA PRKCQ 5588 19 25 52

Total number of gains: 57; Total number of losses: 95; Total Number of normals: 336.  

 

Somatic mutations of PRKCQ:

 

Generating mutation plots.

 

Highly correlated genes for PRKCQ:

 

Showing top 20/108 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCQPRKCQ-AS10.758029606
PRKCQCHRNB30.676356303
PRKCQCELF20.642398403
PRKCQHSPA60.638287303
PRKCQTAGLN30.635297403
PRKCQPLCL10.634381404
PRKCQR3HCC10.622631403
PRKCQHMGN20.622583303
PRKCQRPS6KA20.61768303
PRKCQCDK200.612612303
PRKCQSELENBP10.605322303
PRKCQACVR2B0.601673403
PRKCQST8SIA20.599854303
PRKCQSOBP0.598945403
PRKCQITGAM0.596553303
PRKCQTMEM106C0.593712303
PRKCQFRZB0.593045504
PRKCQMPP20.59032404
PRKCQEFHD10.590129403
PRKCQGDF90.581284403

For details and further investigation, click here