| Full name: serpin family C member 1 | Alias Symbol: ATIII|MGC22579 | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 462 | HGNC ID: HGNC:775 | Ensembl Gene: ENSG00000117601 | OMIM ID: 107300 |
| Drug and gene relationship at DGIdb | |||
SERPINC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of SERPINC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SERPINC1 | 462 | 210049_at | 0.0257 | 0.9317 | |
| GSE20347 | SERPINC1 | 462 | 210049_at | -0.0384 | 0.5819 | |
| GSE23400 | SERPINC1 | 462 | 210049_at | -0.1278 | 0.0006 | |
| GSE26886 | SERPINC1 | 462 | 210049_at | 0.0097 | 0.9525 | |
| GSE29001 | SERPINC1 | 462 | 210049_at | -0.1114 | 0.5093 | |
| GSE38129 | SERPINC1 | 462 | 210049_at | -0.0535 | 0.3379 | |
| GSE45670 | SERPINC1 | 462 | 210049_at | -0.0233 | 0.8044 | |
| GSE53622 | SERPINC1 | 462 | 81238 | -0.3953 | 0.0172 | |
| GSE53624 | SERPINC1 | 462 | 81238 | -0.7141 | 0.0000 | |
| GSE63941 | SERPINC1 | 462 | 210049_at | 0.0013 | 0.9948 | |
| GSE77861 | SERPINC1 | 462 | 1554491_a_at | -0.0797 | 0.3186 | |
| TCGA | SERPINC1 | 462 | RNAseq | 0.3395 | 0.6397 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SERPINC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SERPINC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SERPINC1 | 462 | 12 | 0 | 18 | |
| GSE20123 | SERPINC1 | 462 | 12 | 0 | 18 | |
| GSE43470 | SERPINC1 | 462 | 7 | 2 | 34 | |
| GSE46452 | SERPINC1 | 462 | 3 | 1 | 55 | |
| GSE47630 | SERPINC1 | 462 | 14 | 0 | 26 | |
| GSE54993 | SERPINC1 | 462 | 0 | 6 | 64 | |
| GSE54994 | SERPINC1 | 462 | 15 | 0 | 38 | |
| GSE60625 | SERPINC1 | 462 | 0 | 0 | 11 | |
| GSE74703 | SERPINC1 | 462 | 7 | 2 | 27 | |
| GSE74704 | SERPINC1 | 462 | 5 | 0 | 15 | |
| TCGA | SERPINC1 | 462 | 42 | 3 | 51 |
Total number of gains: 117; Total number of losses: 14; Total Number of normals: 357.
Somatic mutations of SERPINC1:
Generating mutation plots.
Highly correlated genes for SERPINC1:
Showing top 20/344 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SERPINC1 | RIT2 | 0.698673 | 4 | 0 | 4 |
| SERPINC1 | GCG | 0.68037 | 3 | 0 | 3 |
| SERPINC1 | PTPRN2 | 0.675021 | 4 | 0 | 4 |
| SERPINC1 | FCAR | 0.668335 | 4 | 0 | 4 |
| SERPINC1 | WNT16 | 0.667589 | 3 | 0 | 3 |
| SERPINC1 | CHRNB3 | 0.664184 | 3 | 0 | 3 |
| SERPINC1 | AMBN | 0.658539 | 4 | 0 | 4 |
| SERPINC1 | ZFP2 | 0.64619 | 4 | 0 | 4 |
| SERPINC1 | PLCH1 | 0.642753 | 3 | 0 | 3 |
| SERPINC1 | DNM3OS | 0.639687 | 3 | 0 | 3 |
| SERPINC1 | P2RX6 | 0.638275 | 4 | 0 | 4 |
| SERPINC1 | PIK3R5 | 0.637421 | 4 | 0 | 4 |
| SERPINC1 | CACNB1 | 0.635102 | 5 | 0 | 4 |
| SERPINC1 | N4BP2L1 | 0.633536 | 3 | 0 | 3 |
| SERPINC1 | PAX3 | 0.632272 | 4 | 0 | 3 |
| SERPINC1 | OR2H2 | 0.630824 | 4 | 0 | 4 |
| SERPINC1 | FBP2 | 0.629569 | 4 | 0 | 4 |
| SERPINC1 | CCDC82 | 0.629417 | 4 | 0 | 4 |
| SERPINC1 | FSHR | 0.629307 | 5 | 0 | 4 |
| SERPINC1 | AP4S1 | 0.628755 | 4 | 0 | 4 |
For details and further investigation, click here
