| Full name: claudin 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 9074 | HGNC ID: HGNC:2048 | Ensembl Gene: ENSG00000184697 | OMIM ID: 615798 |
| Drug and gene relationship at DGIdb | |||
CLDN6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN6 | 9074 | 208474_at | -0.0619 | 0.8004 | |
| GSE20347 | CLDN6 | 9074 | 208474_at | -0.0519 | 0.5589 | |
| GSE23400 | CLDN6 | 9074 | 208474_at | -0.1315 | 0.0270 | |
| GSE26886 | CLDN6 | 9074 | 208474_at | 0.0913 | 0.5145 | |
| GSE29001 | CLDN6 | 9074 | 208474_at | -0.2841 | 0.1614 | |
| GSE38129 | CLDN6 | 9074 | 208474_at | -0.1362 | 0.2435 | |
| GSE45670 | CLDN6 | 9074 | 208474_at | -0.1476 | 0.1267 | |
| GSE53622 | CLDN6 | 9074 | 21540 | 0.8596 | 0.0000 | |
| GSE53624 | CLDN6 | 9074 | 21540 | 0.7362 | 0.0000 | |
| GSE63941 | CLDN6 | 9074 | 208474_at | 0.2257 | 0.1429 | |
| GSE77861 | CLDN6 | 9074 | 208474_at | 0.0531 | 0.7240 | |
| GSE97050 | CLDN6 | 9074 | A_23_P37942 | 0.6299 | 0.4049 | |
| TCGA | CLDN6 | 9074 | RNAseq | 3.8793 | 0.0003 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CLDN6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN6 | 9074 | 5 | 5 | 20 | |
| GSE20123 | CLDN6 | 9074 | 5 | 4 | 21 | |
| GSE43470 | CLDN6 | 9074 | 3 | 8 | 32 | |
| GSE46452 | CLDN6 | 9074 | 38 | 1 | 20 | |
| GSE47630 | CLDN6 | 9074 | 13 | 6 | 21 | |
| GSE54993 | CLDN6 | 9074 | 3 | 5 | 62 | |
| GSE54994 | CLDN6 | 9074 | 5 | 9 | 39 | |
| GSE60625 | CLDN6 | 9074 | 4 | 0 | 7 | |
| GSE74703 | CLDN6 | 9074 | 3 | 6 | 27 | |
| GSE74704 | CLDN6 | 9074 | 3 | 2 | 15 | |
| TCGA | CLDN6 | 9074 | 19 | 13 | 64 |
Total number of gains: 101; Total number of losses: 59; Total Number of normals: 328.
Somatic mutations of CLDN6:
Generating mutation plots.
Highly correlated genes for CLDN6:
Showing top 20/498 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN6 | SHOX | 0.795995 | 3 | 0 | 3 |
| CLDN6 | CCDC71 | 0.688902 | 8 | 0 | 7 |
| CLDN6 | CYP11B2 | 0.684467 | 8 | 0 | 7 |
| CLDN6 | MLXIPL | 0.68393 | 9 | 0 | 9 |
| CLDN6 | CCL1 | 0.681102 | 3 | 0 | 3 |
| CLDN6 | PROX1 | 0.679087 | 4 | 0 | 3 |
| CLDN6 | MUC3B | 0.676122 | 7 | 0 | 5 |
| CLDN6 | ARR3 | 0.670608 | 3 | 0 | 3 |
| CLDN6 | TMEM59L | 0.668582 | 7 | 0 | 7 |
| CLDN6 | SLC4A1 | 0.667031 | 5 | 0 | 5 |
| CLDN6 | LINC00837 | 0.666694 | 3 | 0 | 3 |
| CLDN6 | CCDC30 | 0.665725 | 4 | 0 | 4 |
| CLDN6 | GPR52 | 0.665679 | 3 | 0 | 3 |
| CLDN6 | OR2F2 | 0.663864 | 3 | 0 | 3 |
| CLDN6 | GRIA1 | 0.660557 | 3 | 0 | 3 |
| CLDN6 | EPO | 0.658592 | 7 | 0 | 5 |
| CLDN6 | HDAC7 | 0.65833 | 3 | 0 | 3 |
| CLDN6 | POU2F2 | 0.655965 | 5 | 0 | 4 |
| CLDN6 | SFN | 0.655115 | 3 | 0 | 3 |
| CLDN6 | CLDN15 | 0.654954 | 3 | 0 | 3 |
For details and further investigation, click here
