| Full name: stratifin | Alias Symbol: YWHAS | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 2810 | HGNC ID: HGNC:10773 | Ensembl Gene: ENSG00000175793 | OMIM ID: 601290 |
| Drug and gene relationship at DGIdb | |||
SFN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04110 | Cell cycle | |
| hsa04115 | p53 signaling pathway | |
| hsa04960 | Aldosterone-regulated sodium reabsorption |
Expression of SFN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SFN | 2810 | 33322_i_at | -0.0991 | 0.7567 | |
| GSE20347 | SFN | 2810 | 33322_i_at | -0.1855 | 0.1598 | |
| GSE23400 | SFN | 2810 | 33322_i_at | 0.0133 | 0.8993 | |
| GSE26886 | SFN | 2810 | 33323_r_at | -0.3095 | 0.0108 | |
| GSE29001 | SFN | 2810 | 33322_i_at | -0.0054 | 0.9679 | |
| GSE38129 | SFN | 2810 | 33322_i_at | 0.6981 | 0.1700 | |
| GSE45670 | SFN | 2810 | 33323_r_at | 0.1756 | 0.0393 | |
| GSE53622 | SFN | 2810 | 58582 | -0.1056 | 0.5924 | |
| GSE53624 | SFN | 2810 | 58582 | -0.1447 | 0.0974 | |
| GSE63941 | SFN | 2810 | 33322_i_at | 5.0991 | 0.0001 | |
| GSE77861 | SFN | 2810 | 33322_i_at | -0.0429 | 0.7911 | |
| GSE97050 | SFN | 2810 | A_33_P3389286 | 0.4675 | 0.5619 | |
| SRP007169 | SFN | 2810 | RNAseq | -1.9096 | 0.0000 | |
| SRP008496 | SFN | 2810 | RNAseq | -1.6816 | 0.0000 | |
| SRP064894 | SFN | 2810 | RNAseq | -0.4609 | 0.3226 | |
| SRP133303 | SFN | 2810 | RNAseq | -0.3848 | 0.3051 | |
| SRP159526 | SFN | 2810 | RNAseq | -1.3805 | 0.0212 | |
| SRP193095 | SFN | 2810 | RNAseq | -0.4062 | 0.2512 | |
| SRP219564 | SFN | 2810 | RNAseq | -1.0246 | 0.3498 | |
| TCGA | SFN | 2810 | RNAseq | 0.8520 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by SFN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SFN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SFN | 2810 | 0 | 6 | 24 | |
| GSE20123 | SFN | 2810 | 0 | 5 | 25 | |
| GSE43470 | SFN | 2810 | 2 | 6 | 35 | |
| GSE46452 | SFN | 2810 | 5 | 1 | 53 | |
| GSE47630 | SFN | 2810 | 8 | 3 | 29 | |
| GSE54993 | SFN | 2810 | 2 | 1 | 67 | |
| GSE54994 | SFN | 2810 | 10 | 4 | 39 | |
| GSE60625 | SFN | 2810 | 0 | 0 | 11 | |
| GSE74703 | SFN | 2810 | 1 | 4 | 31 | |
| GSE74704 | SFN | 2810 | 0 | 0 | 20 | |
| TCGA | SFN | 2810 | 10 | 24 | 62 |
Total number of gains: 38; Total number of losses: 54; Total Number of normals: 396.
Somatic mutations of SFN:
Generating mutation plots.
Highly correlated genes for SFN:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SFN | S100A2 | 0.779332 | 12 | 0 | 12 |
| SFN | IRX2 | 0.741378 | 3 | 0 | 3 |
| SFN | FAM83H | 0.724359 | 6 | 0 | 6 |
| SFN | ZNF460 | 0.719309 | 3 | 0 | 3 |
| SFN | KRT6A | 0.717912 | 12 | 0 | 11 |
| SFN | MAL2 | 0.713148 | 4 | 0 | 3 |
| SFN | SH3RF2 | 0.702194 | 7 | 0 | 6 |
| SFN | KRT6C | 0.699709 | 4 | 0 | 3 |
| SFN | FAM83G | 0.698736 | 7 | 0 | 6 |
| SFN | STAP2 | 0.696817 | 4 | 0 | 3 |
| SFN | ESRP1 | 0.695363 | 6 | 0 | 4 |
| SFN | FAM110C | 0.695133 | 7 | 0 | 6 |
| SFN | GNA15 | 0.694394 | 13 | 0 | 12 |
| SFN | DSP | 0.694355 | 8 | 0 | 6 |
| SFN | KRT6B | 0.690831 | 12 | 0 | 12 |
| SFN | MPZL2 | 0.686733 | 9 | 0 | 8 |
| SFN | DSC3 | 0.686268 | 10 | 0 | 8 |
| SFN | PKP1 | 0.684376 | 9 | 0 | 6 |
| SFN | TNNT1 | 0.684034 | 4 | 0 | 3 |
| SFN | DSG3 | 0.683728 | 10 | 0 | 8 |
For details and further investigation, click here
