PMPCA

 

Full name: peptidase, mitochondrial processing alpha subunit Alias Symbol: KIAA0123|Alpha-MPP
Type: protein-coding gene Cytoband: 9q34.3
Entrez ID: 23203 HGNC ID: HGNC:18667 Ensembl Gene: ENSG00000165688 OMIM ID: 613036
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of PMPCA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PMPCA 23203 212088_at 0.3575 0.2154
GSE20347 PMPCA 23203 212088_at 0.0873 0.5145
GSE23400 PMPCA 23203 212088_at 0.1979 0.0002
GSE26886 PMPCA 23203 212088_at 0.2857 0.0793
GSE29001 PMPCA 23203 212088_at 0.1203 0.7043
GSE38129 PMPCA 23203 212088_at 0.2129 0.0251
GSE45670 PMPCA 23203 212088_at 0.1625 0.2119
GSE53622 PMPCA 23203 52520 0.2919 0.0004
GSE53624 PMPCA 23203 52520 0.5429 0.0000
GSE63941 PMPCA 23203 212088_at 0.9801 0.0176
GSE77861 PMPCA 23203 212088_at 0.0739 0.7302
GSE97050 PMPCA 23203 A_33_P3287537 0.2074 0.3757
SRP007169 PMPCA 23203 RNAseq 0.7756 0.0442
SRP008496 PMPCA 23203 RNAseq 0.3031 0.3617
SRP064894 PMPCA 23203 RNAseq 0.6223 0.0046
SRP133303 PMPCA 23203 RNAseq 0.3463 0.0525
SRP159526 PMPCA 23203 RNAseq 0.2820 0.1085
SRP193095 PMPCA 23203 RNAseq 0.2664 0.0134
SRP219564 PMPCA 23203 RNAseq 0.3857 0.4215
TCGA PMPCA 23203 RNAseq 0.0203 0.7034

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PMPCA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PMPCA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PMPCA 23203 4 7 19
GSE20123 PMPCA 23203 4 7 19
GSE43470 PMPCA 23203 3 7 33
GSE46452 PMPCA 23203 6 13 40
GSE47630 PMPCA 23203 6 15 19
GSE54993 PMPCA 23203 3 3 64
GSE54994 PMPCA 23203 13 7 33
GSE60625 PMPCA 23203 0 0 11
GSE74703 PMPCA 23203 3 5 28
GSE74704 PMPCA 23203 2 5 13
TCGA PMPCA 23203 29 24 43

Total number of gains: 73; Total number of losses: 93; Total Number of normals: 322.  

 

Somatic mutations of PMPCA:

 

Generating mutation plots.

 

Highly correlated genes for PMPCA:

 

Showing top 20/190 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PMPCAARL8A0.750083303
PMPCADNAL40.746312303
PMPCACLN30.737144303
PMPCASETD1B0.728586303
PMPCAFAM181A0.718344303
PMPCATIGD70.714758303
PMPCAAP2A10.713292303
PMPCAMRPS20.69764613012
PMPCABATF0.684233303
PMPCAPRDM130.668887403
PMPCASNORA71A0.66574303
PMPCATMUB10.660276403
PMPCAWDR830.654221403
PMPCANELFB0.64948110010
PMPCAZNF4280.646592303
PMPCATMEM1020.645635403
PMPCAJRK0.645512303
PMPCACPAMD80.644438403
PMPCAINIP0.643417303
PMPCASTK110.642438403

For details and further investigation, click here