| Full name: hydroxymethylbilane synthase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 3145 | HGNC ID: HGNC:4982 | Ensembl Gene: ENSG00000256269 | OMIM ID: 609806 |
| Drug and gene relationship at DGIdb | |||
Expression of HMBS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMBS | 3145 | 203040_s_at | 0.6191 | 0.1168 | |
| GSE20347 | HMBS | 3145 | 203040_s_at | 0.4741 | 0.0002 | |
| GSE23400 | HMBS | 3145 | 203040_s_at | 0.3689 | 0.0000 | |
| GSE26886 | HMBS | 3145 | 203040_s_at | 0.2783 | 0.3499 | |
| GSE29001 | HMBS | 3145 | 203040_s_at | 0.2650 | 0.2903 | |
| GSE38129 | HMBS | 3145 | 203040_s_at | 0.4734 | 0.0004 | |
| GSE45670 | HMBS | 3145 | 203040_s_at | 0.5300 | 0.0005 | |
| GSE53622 | HMBS | 3145 | 53183 | 0.4968 | 0.0000 | |
| GSE53624 | HMBS | 3145 | 53183 | 0.4740 | 0.0000 | |
| GSE63941 | HMBS | 3145 | 203040_s_at | 0.5162 | 0.1396 | |
| GSE77861 | HMBS | 3145 | 203040_s_at | 0.5147 | 0.1103 | |
| GSE97050 | HMBS | 3145 | A_23_P98431 | 0.1796 | 0.4639 | |
| SRP007169 | HMBS | 3145 | RNAseq | -0.2630 | 0.4213 | |
| SRP008496 | HMBS | 3145 | RNAseq | 0.0149 | 0.9593 | |
| SRP064894 | HMBS | 3145 | RNAseq | 0.6777 | 0.0069 | |
| SRP133303 | HMBS | 3145 | RNAseq | 0.2426 | 0.1977 | |
| SRP159526 | HMBS | 3145 | RNAseq | 0.5489 | 0.1845 | |
| SRP193095 | HMBS | 3145 | RNAseq | -0.0749 | 0.6390 | |
| SRP219564 | HMBS | 3145 | RNAseq | 0.6275 | 0.2295 | |
| TCGA | HMBS | 3145 | RNAseq | 0.2087 | 0.0150 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HMBS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMBS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMBS | 3145 | 1 | 11 | 18 | |
| GSE20123 | HMBS | 3145 | 1 | 11 | 18 | |
| GSE43470 | HMBS | 3145 | 2 | 8 | 33 | |
| GSE46452 | HMBS | 3145 | 3 | 26 | 30 | |
| GSE47630 | HMBS | 3145 | 2 | 19 | 19 | |
| GSE54993 | HMBS | 3145 | 10 | 0 | 60 | |
| GSE54994 | HMBS | 3145 | 5 | 19 | 29 | |
| GSE60625 | HMBS | 3145 | 0 | 3 | 8 | |
| GSE74703 | HMBS | 3145 | 1 | 5 | 30 | |
| GSE74704 | HMBS | 3145 | 0 | 7 | 13 | |
| TCGA | HMBS | 3145 | 4 | 51 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of HMBS:
Generating mutation plots.
Highly correlated genes for HMBS:
Showing top 20/369 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMBS | FBRSL1 | 0.774365 | 3 | 0 | 3 |
| HMBS | WDR55 | 0.733759 | 3 | 0 | 3 |
| HMBS | CLN3 | 0.712231 | 3 | 0 | 3 |
| HMBS | CDCA5 | 0.700029 | 6 | 0 | 5 |
| HMBS | CBX8 | 0.679565 | 4 | 0 | 4 |
| HMBS | MTFR2 | 0.672419 | 5 | 0 | 4 |
| HMBS | RFT1 | 0.667893 | 5 | 0 | 3 |
| HMBS | ATG16L1 | 0.663321 | 3 | 0 | 3 |
| HMBS | KCNH3 | 0.661839 | 3 | 0 | 3 |
| HMBS | SLC4A11 | 0.66109 | 5 | 0 | 4 |
| HMBS | SPRR2G | 0.660454 | 3 | 0 | 3 |
| HMBS | ALOX12B | 0.659721 | 5 | 0 | 3 |
| HMBS | CDC6 | 0.657622 | 8 | 0 | 6 |
| HMBS | LRFN4 | 0.657578 | 6 | 0 | 5 |
| HMBS | LRWD1 | 0.657559 | 3 | 0 | 3 |
| HMBS | HAUS8 | 0.65671 | 6 | 0 | 4 |
| HMBS | CYB561A3 | 0.655536 | 4 | 0 | 3 |
| HMBS | FEN1 | 0.654502 | 8 | 0 | 7 |
| HMBS | PFN4 | 0.652311 | 3 | 0 | 3 |
| HMBS | ASGR2 | 0.650703 | 3 | 0 | 3 |
For details and further investigation, click here
