| Full name: CCR4-NOT transcription complex subunit 2 | Alias Symbol: CDC36|NOT2H | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 4848 | HGNC ID: HGNC:7878 | Ensembl Gene: | OMIM ID: 604909 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT2 | 4848 | 222182_s_at | 0.1517 | 0.7331 | |
| GSE20347 | CNOT2 | 4848 | 222182_s_at | 0.0958 | 0.5621 | |
| GSE23400 | CNOT2 | 4848 | 217798_at | 0.3738 | 0.0001 | |
| GSE26886 | CNOT2 | 4848 | 222182_s_at | 0.7257 | 0.0009 | |
| GSE29001 | CNOT2 | 4848 | 222182_s_at | 0.1281 | 0.5516 | |
| GSE38129 | CNOT2 | 4848 | 222182_s_at | 0.2492 | 0.0218 | |
| GSE45670 | CNOT2 | 4848 | 222182_s_at | 0.0849 | 0.6094 | |
| GSE53622 | CNOT2 | 4848 | 56786 | 0.4630 | 0.0000 | |
| GSE53624 | CNOT2 | 4848 | 56786 | 0.3861 | 0.0000 | |
| GSE63941 | CNOT2 | 4848 | 222182_s_at | -0.0666 | 0.9117 | |
| GSE77861 | CNOT2 | 4848 | 222182_s_at | 0.1856 | 0.3067 | |
| GSE97050 | CNOT2 | 4848 | A_23_P162336 | 0.3041 | 0.1801 | |
| SRP007169 | CNOT2 | 4848 | RNAseq | -0.4264 | 0.1871 | |
| SRP008496 | CNOT2 | 4848 | RNAseq | -0.2499 | 0.1419 | |
| SRP064894 | CNOT2 | 4848 | RNAseq | 0.2184 | 0.0150 | |
| SRP133303 | CNOT2 | 4848 | RNAseq | 0.6146 | 0.0406 | |
| SRP159526 | CNOT2 | 4848 | RNAseq | 0.2282 | 0.3624 | |
| SRP193095 | CNOT2 | 4848 | RNAseq | 0.0091 | 0.9199 | |
| SRP219564 | CNOT2 | 4848 | RNAseq | 0.7066 | 0.1912 | |
| TCGA | CNOT2 | 4848 | RNAseq | 0.1381 | 0.0039 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CNOT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT2 | 4848 | 6 | 0 | 24 | |
| GSE20123 | CNOT2 | 4848 | 6 | 0 | 24 | |
| GSE43470 | CNOT2 | 4848 | 4 | 0 | 39 | |
| GSE46452 | CNOT2 | 4848 | 10 | 1 | 48 | |
| GSE47630 | CNOT2 | 4848 | 10 | 1 | 29 | |
| GSE54993 | CNOT2 | 4848 | 0 | 6 | 64 | |
| GSE54994 | CNOT2 | 4848 | 8 | 1 | 44 | |
| GSE60625 | CNOT2 | 4848 | 0 | 0 | 11 | |
| GSE74703 | CNOT2 | 4848 | 4 | 0 | 32 | |
| GSE74704 | CNOT2 | 4848 | 5 | 0 | 15 | |
| TCGA | CNOT2 | 4848 | 22 | 8 | 66 |
Total number of gains: 75; Total number of losses: 17; Total Number of normals: 396.
Somatic mutations of CNOT2:
Generating mutation plots.
Highly correlated genes for CNOT2:
Showing top 20/484 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT2 | PAK1IP1 | 0.825627 | 3 | 0 | 3 |
| CNOT2 | LMLN | 0.812012 | 3 | 0 | 3 |
| CNOT2 | CCDC15 | 0.8059 | 3 | 0 | 3 |
| CNOT2 | TRIM8 | 0.766798 | 3 | 0 | 3 |
| CNOT2 | RLF | 0.764735 | 3 | 0 | 3 |
| CNOT2 | RRP36 | 0.764632 | 3 | 0 | 3 |
| CNOT2 | SON | 0.764577 | 3 | 0 | 3 |
| CNOT2 | BOD1 | 0.758389 | 3 | 0 | 3 |
| CNOT2 | LATS1 | 0.75448 | 3 | 0 | 3 |
| CNOT2 | SPA17 | 0.754015 | 3 | 0 | 3 |
| CNOT2 | LGALS8 | 0.752946 | 3 | 0 | 3 |
| CNOT2 | RPL22L1 | 0.750438 | 3 | 0 | 3 |
| CNOT2 | SLC25A44 | 0.746785 | 3 | 0 | 3 |
| CNOT2 | FAF2 | 0.745737 | 4 | 0 | 4 |
| CNOT2 | RBM33 | 0.744719 | 3 | 0 | 3 |
| CNOT2 | ZNF766 | 0.739433 | 4 | 0 | 4 |
| CNOT2 | ZNF562 | 0.733322 | 3 | 0 | 3 |
| CNOT2 | LY75 | 0.733052 | 3 | 0 | 3 |
| CNOT2 | FXR1 | 0.732833 | 3 | 0 | 3 |
| CNOT2 | TBC1D8 | 0.729024 | 4 | 0 | 3 |
For details and further investigation, click here
