| Full name: PAK1 interacting protein 1 | Alias Symbol: FLJ20624|hPIP1|PIP1|bA421M1.5|MAK11|WDR84 | ||
| Type: protein-coding gene | Cytoband: 6p24.2 | ||
| Entrez ID: 55003 | HGNC ID: HGNC:20882 | Ensembl Gene: ENSG00000111845 | OMIM ID: 607811 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PAK1IP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAK1IP1 | 55003 | 218886_at | 0.9694 | 0.2419 | |
| GSE20347 | PAK1IP1 | 55003 | 218886_at | 0.2844 | 0.1343 | |
| GSE23400 | PAK1IP1 | 55003 | 218886_at | 0.4317 | 0.0000 | |
| GSE26886 | PAK1IP1 | 55003 | 218886_at | 0.3915 | 0.2089 | |
| GSE29001 | PAK1IP1 | 55003 | 218886_at | 0.1620 | 0.5726 | |
| GSE38129 | PAK1IP1 | 55003 | 218886_at | 0.3834 | 0.1294 | |
| GSE45670 | PAK1IP1 | 55003 | 218886_at | 0.4808 | 0.0024 | |
| GSE53622 | PAK1IP1 | 55003 | 141779 | 0.2969 | 0.0002 | |
| GSE53624 | PAK1IP1 | 55003 | 141779 | 0.4084 | 0.0000 | |
| GSE63941 | PAK1IP1 | 55003 | 218886_at | 0.2451 | 0.6039 | |
| GSE77861 | PAK1IP1 | 55003 | 218886_at | -0.0370 | 0.9134 | |
| GSE97050 | PAK1IP1 | 55003 | A_23_P122674 | 0.5535 | 0.1753 | |
| SRP007169 | PAK1IP1 | 55003 | RNAseq | 0.5925 | 0.1296 | |
| SRP008496 | PAK1IP1 | 55003 | RNAseq | 0.3264 | 0.2322 | |
| SRP064894 | PAK1IP1 | 55003 | RNAseq | 0.0743 | 0.7018 | |
| SRP133303 | PAK1IP1 | 55003 | RNAseq | 0.2379 | 0.1627 | |
| SRP159526 | PAK1IP1 | 55003 | RNAseq | 0.5628 | 0.0531 | |
| SRP193095 | PAK1IP1 | 55003 | RNAseq | -0.3249 | 0.0419 | |
| SRP219564 | PAK1IP1 | 55003 | RNAseq | -0.0229 | 0.9489 | |
| TCGA | PAK1IP1 | 55003 | RNAseq | 0.3286 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PAK1IP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAK1IP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAK1IP1 | 55003 | 4 | 7 | 19 | |
| GSE20123 | PAK1IP1 | 55003 | 4 | 7 | 19 | |
| GSE43470 | PAK1IP1 | 55003 | 8 | 2 | 33 | |
| GSE46452 | PAK1IP1 | 55003 | 1 | 10 | 48 | |
| GSE47630 | PAK1IP1 | 55003 | 7 | 8 | 25 | |
| GSE54993 | PAK1IP1 | 55003 | 1 | 1 | 68 | |
| GSE54994 | PAK1IP1 | 55003 | 10 | 3 | 40 | |
| GSE60625 | PAK1IP1 | 55003 | 0 | 1 | 10 | |
| GSE74703 | PAK1IP1 | 55003 | 7 | 2 | 27 | |
| GSE74704 | PAK1IP1 | 55003 | 2 | 3 | 15 | |
| TCGA | PAK1IP1 | 55003 | 15 | 28 | 53 |
Total number of gains: 59; Total number of losses: 72; Total Number of normals: 357.
Somatic mutations of PAK1IP1:
Generating mutation plots.
Highly correlated genes for PAK1IP1:
Showing top 20/562 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAK1IP1 | CNOT2 | 0.825627 | 3 | 0 | 3 |
| PAK1IP1 | PPP1R37 | 0.792038 | 3 | 0 | 3 |
| PAK1IP1 | EIF3C | 0.791705 | 3 | 0 | 3 |
| PAK1IP1 | CEP350 | 0.786765 | 3 | 0 | 3 |
| PAK1IP1 | UTP3 | 0.762187 | 3 | 0 | 3 |
| PAK1IP1 | GTPBP8 | 0.751115 | 5 | 0 | 5 |
| PAK1IP1 | CELF1 | 0.743987 | 5 | 0 | 5 |
| PAK1IP1 | WIPI2 | 0.74096 | 3 | 0 | 3 |
| PAK1IP1 | BZW1 | 0.72016 | 3 | 0 | 3 |
| PAK1IP1 | DGKH | 0.715577 | 3 | 0 | 3 |
| PAK1IP1 | DPP9 | 0.711712 | 4 | 0 | 3 |
| PAK1IP1 | EBNA1BP2 | 0.710187 | 3 | 0 | 3 |
| PAK1IP1 | STAU1 | 0.708643 | 3 | 0 | 3 |
| PAK1IP1 | UCK2 | 0.704676 | 3 | 0 | 3 |
| PAK1IP1 | GATAD2B | 0.703142 | 3 | 0 | 3 |
| PAK1IP1 | LZIC | 0.699421 | 3 | 0 | 3 |
| PAK1IP1 | RPLP2 | 0.694903 | 3 | 0 | 3 |
| PAK1IP1 | KLHL20 | 0.692432 | 3 | 0 | 3 |
| PAK1IP1 | HNRNPAB | 0.688488 | 4 | 0 | 3 |
| PAK1IP1 | RIOK1 | 0.686057 | 8 | 0 | 6 |
For details and further investigation, click here
