| Full name: Coenzyme A synthase | Alias Symbol: DPCK|NBP|CoASY|PPAT | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 80347 | HGNC ID: HGNC:29932 | Ensembl Gene: ENSG00000068120 | OMIM ID: 609855 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COASY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COASY | 80347 | 201913_s_at | 0.4237 | 0.3859 | |
| GSE20347 | COASY | 80347 | 201913_s_at | 0.1539 | 0.1846 | |
| GSE23400 | COASY | 80347 | 201913_s_at | 0.2271 | 0.0003 | |
| GSE26886 | COASY | 80347 | 201913_s_at | -0.1774 | 0.3312 | |
| GSE29001 | COASY | 80347 | 201913_s_at | 0.0984 | 0.7701 | |
| GSE38129 | COASY | 80347 | 201913_s_at | 0.3329 | 0.0138 | |
| GSE45670 | COASY | 80347 | 201913_s_at | 0.3614 | 0.0019 | |
| GSE53622 | COASY | 80347 | 168217 | 0.2342 | 0.0067 | |
| GSE53624 | COASY | 80347 | 168217 | 0.2630 | 0.0001 | |
| GSE63941 | COASY | 80347 | 201913_s_at | 0.9779 | 0.0030 | |
| GSE77861 | COASY | 80347 | 201913_s_at | 0.3200 | 0.1209 | |
| GSE97050 | COASY | 80347 | A_23_P4144 | 0.4534 | 0.3631 | |
| SRP007169 | COASY | 80347 | RNAseq | -0.1440 | 0.6706 | |
| SRP008496 | COASY | 80347 | RNAseq | -0.4003 | 0.2655 | |
| SRP064894 | COASY | 80347 | RNAseq | 0.4650 | 0.0230 | |
| SRP133303 | COASY | 80347 | RNAseq | 0.0518 | 0.8266 | |
| SRP159526 | COASY | 80347 | RNAseq | -0.0864 | 0.6762 | |
| SRP193095 | COASY | 80347 | RNAseq | -0.0747 | 0.4120 | |
| SRP219564 | COASY | 80347 | RNAseq | 0.2319 | 0.5284 | |
| TCGA | COASY | 80347 | RNAseq | 0.0435 | 0.3501 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COASY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COASY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COASY | 80347 | 6 | 2 | 22 | |
| GSE20123 | COASY | 80347 | 6 | 2 | 22 | |
| GSE43470 | COASY | 80347 | 1 | 2 | 40 | |
| GSE46452 | COASY | 80347 | 34 | 0 | 25 | |
| GSE47630 | COASY | 80347 | 8 | 1 | 31 | |
| GSE54993 | COASY | 80347 | 3 | 4 | 63 | |
| GSE54994 | COASY | 80347 | 8 | 5 | 40 | |
| GSE60625 | COASY | 80347 | 4 | 0 | 7 | |
| GSE74703 | COASY | 80347 | 1 | 1 | 34 | |
| GSE74704 | COASY | 80347 | 4 | 1 | 15 | |
| TCGA | COASY | 80347 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of COASY:
Generating mutation plots.
Highly correlated genes for COASY:
Showing top 20/913 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COASY | PRELID1 | 0.766441 | 3 | 0 | 3 |
| COASY | ZNF267 | 0.752542 | 3 | 0 | 3 |
| COASY | TMEM170A | 0.73321 | 3 | 0 | 3 |
| COASY | FOPNL | 0.718761 | 3 | 0 | 3 |
| COASY | SPCS2 | 0.717607 | 3 | 0 | 3 |
| COASY | C1orf56 | 0.717266 | 3 | 0 | 3 |
| COASY | TMEM167A | 0.705874 | 3 | 0 | 3 |
| COASY | EMG1 | 0.700678 | 5 | 0 | 5 |
| COASY | ID1 | 0.7 | 3 | 0 | 3 |
| COASY | TRAF7 | 0.698441 | 5 | 0 | 5 |
| COASY | DARS2 | 0.696149 | 6 | 0 | 5 |
| COASY | EME1 | 0.692303 | 5 | 0 | 5 |
| COASY | AP1S3 | 0.689324 | 5 | 0 | 4 |
| COASY | SLC25A39 | 0.685662 | 8 | 0 | 7 |
| COASY | PSMG3 | 0.684854 | 6 | 0 | 5 |
| COASY | BCL9L | 0.684788 | 3 | 0 | 3 |
| COASY | EIF5A | 0.682789 | 4 | 0 | 4 |
| COASY | SLC50A1 | 0.678053 | 9 | 0 | 7 |
| COASY | FANCD2 | 0.677088 | 5 | 0 | 5 |
| COASY | GPR160 | 0.67682 | 4 | 0 | 3 |
For details and further investigation, click here
