| Full name: eukaryotic translation initiation factor 5A | Alias Symbol: EIF5A1|EIF-5A|MGC99547|MGC104255 | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1984 | HGNC ID: HGNC:3300 | Ensembl Gene: ENSG00000132507 | OMIM ID: 600187 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EIF5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF5A | 1984 | 201123_s_at | -0.4242 | 0.6524 | |
| GSE20347 | EIF5A | 1984 | 201122_x_at | -0.2404 | 0.3733 | |
| GSE23400 | EIF5A | 1984 | 213753_x_at | 0.0711 | 0.4188 | |
| GSE26886 | EIF5A | 1984 | 201122_x_at | -0.2838 | 0.4347 | |
| GSE29001 | EIF5A | 1984 | 201122_x_at | -0.0828 | 0.7741 | |
| GSE38129 | EIF5A | 1984 | 201123_s_at | 0.3072 | 0.5506 | |
| GSE45670 | EIF5A | 1984 | 201123_s_at | 0.0495 | 0.8992 | |
| GSE53622 | EIF5A | 1984 | 107229 | 0.0944 | 0.2255 | |
| GSE53624 | EIF5A | 1984 | 107229 | 0.2338 | 0.0012 | |
| GSE63941 | EIF5A | 1984 | 201123_s_at | 0.8041 | 0.3251 | |
| GSE77861 | EIF5A | 1984 | 201123_s_at | 0.2207 | 0.8067 | |
| GSE97050 | EIF5A | 1984 | A_24_P31235 | 0.5164 | 0.1963 | |
| SRP007169 | EIF5A | 1984 | RNAseq | -0.7376 | 0.0139 | |
| SRP008496 | EIF5A | 1984 | RNAseq | -0.8578 | 0.0000 | |
| SRP064894 | EIF5A | 1984 | RNAseq | 0.2384 | 0.2856 | |
| SRP133303 | EIF5A | 1984 | RNAseq | 0.1614 | 0.5008 | |
| SRP159526 | EIF5A | 1984 | RNAseq | 0.0870 | 0.7162 | |
| SRP193095 | EIF5A | 1984 | RNAseq | -0.1307 | 0.4072 | |
| SRP219564 | EIF5A | 1984 | RNAseq | 0.7762 | 0.0819 | |
| TCGA | EIF5A | 1984 | RNAseq | 0.2598 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF5A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF5A | 1984 | 4 | 2 | 24 | |
| GSE20123 | EIF5A | 1984 | 4 | 3 | 23 | |
| GSE43470 | EIF5A | 1984 | 1 | 4 | 38 | |
| GSE46452 | EIF5A | 1984 | 34 | 1 | 24 | |
| GSE47630 | EIF5A | 1984 | 7 | 1 | 32 | |
| GSE54993 | EIF5A | 1984 | 4 | 3 | 63 | |
| GSE54994 | EIF5A | 1984 | 5 | 8 | 40 | |
| GSE60625 | EIF5A | 1984 | 4 | 0 | 7 | |
| GSE74703 | EIF5A | 1984 | 1 | 2 | 33 | |
| GSE74704 | EIF5A | 1984 | 2 | 1 | 17 | |
| TCGA | EIF5A | 1984 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of EIF5A:
Generating mutation plots.
Highly correlated genes for EIF5A:
Showing top 20/178 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF5A | RPE | 0.742194 | 3 | 0 | 3 |
| EIF5A | MCTS1 | 0.741791 | 3 | 0 | 3 |
| EIF5A | STX10 | 0.723121 | 3 | 0 | 3 |
| EIF5A | MRPL32 | 0.718922 | 3 | 0 | 3 |
| EIF5A | PDLIM1 | 0.711589 | 3 | 0 | 3 |
| EIF5A | DDOST | 0.708723 | 3 | 0 | 3 |
| EIF5A | FLYWCH2 | 0.699567 | 3 | 0 | 3 |
| EIF5A | ATRIP | 0.698882 | 3 | 0 | 3 |
| EIF5A | EBNA1BP2 | 0.698171 | 3 | 0 | 3 |
| EIF5A | WDR4 | 0.696642 | 4 | 0 | 4 |
| EIF5A | OTUB1 | 0.69642 | 4 | 0 | 4 |
| EIF5A | DNAJC7 | 0.694546 | 3 | 0 | 3 |
| EIF5A | B4GALNT4 | 0.684519 | 3 | 0 | 3 |
| EIF5A | CDCA4 | 0.683608 | 3 | 0 | 3 |
| EIF5A | COASY | 0.682789 | 4 | 0 | 4 |
| EIF5A | PSMB6 | 0.676847 | 6 | 0 | 5 |
| EIF5A | TPD52L2 | 0.67128 | 3 | 0 | 3 |
| EIF5A | TNS4 | 0.668464 | 3 | 0 | 3 |
| EIF5A | OPLAH | 0.668163 | 3 | 0 | 3 |
| EIF5A | C1D | 0.664391 | 3 | 0 | 3 |
For details and further investigation, click here
