FANCD2

 

Full name: FA complementation group D2 Alias Symbol: FAD|FA-D2
Type: protein-coding gene Cytoband: 3p25.3
Entrez ID: 2177 HGNC ID: HGNC:3585 Ensembl Gene: ENSG00000144554 OMIM ID: 613984
Drug and gene relationship at DGIdb
Screen Evidence:

 

FANCD2 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of FANCD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FANCD2 2177 242560_at 1.1584 0.1270
GSE26886 FANCD2 2177 242560_at -0.0115 0.9786
GSE45670 FANCD2 2177 242560_at 0.8053 0.0002
GSE53622 FANCD2 2177 132014 0.5727 0.0000
GSE53624 FANCD2 2177 132014 0.3881 0.0003
GSE63941 FANCD2 2177 242560_at 3.2616 0.0000
GSE77861 FANCD2 2177 223545_at -0.0154 0.8883
GSE97050 FANCD2 2177 A_23_P143994 0.8643 0.1453
SRP007169 FANCD2 2177 RNAseq 2.5836 0.0002
SRP008496 FANCD2 2177 RNAseq 1.2194 0.1028
SRP064894 FANCD2 2177 RNAseq 0.4413 0.0746
SRP133303 FANCD2 2177 RNAseq 0.8478 0.0026
SRP159526 FANCD2 2177 RNAseq 0.7768 0.0140
SRP193095 FANCD2 2177 RNAseq 0.4366 0.0028
SRP219564 FANCD2 2177 RNAseq 0.1404 0.7924
TCGA FANCD2 2177 RNAseq 0.7839 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by FANCD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FANCD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FANCD2 2177 1 18 11
GSE20123 FANCD2 2177 1 18 11
GSE43470 FANCD2 2177 1 20 22
GSE46452 FANCD2 2177 2 17 40
GSE47630 FANCD2 2177 2 23 15
GSE54993 FANCD2 2177 6 1 63
GSE54994 FANCD2 2177 3 31 19
GSE60625 FANCD2 2177 5 0 6
GSE74703 FANCD2 2177 1 16 19
GSE74704 FANCD2 2177 1 11 8
TCGA FANCD2 2177 5 65 26

Total number of gains: 28; Total number of losses: 220; Total Number of normals: 240.  

 

Somatic mutations of FANCD2:

 

Generating mutation plots.

 

Highly correlated genes for FANCD2:

 

Showing top 20/905 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FANCD2BUB1B0.825143404
FANCD2BIRC50.817207606
FANCD2RCC10.793183505
FANCD2KPNA20.78416505
FANCD2MYBL20.78321505
FANCD2CDH30.777928404
FANCD2SP140L0.771554303
FANCD2PPP1CA0.769703403
FANCD2SLC25A390.765221404
FANCD2NCAPH0.760526404
FANCD2CDCA20.758191505
FANCD2CCNA20.752577706
FANCD2KIF18B0.751795606
FANCD2TOP2A0.750043707
FANCD2KIF110.749101706
FANCD2CDK10.744958706
FANCD2TSPAN170.744227303
FANCD2NUSAP10.743757706
FANCD2MKI670.740509706
FANCD2ASPM0.737749707

For details and further investigation, click here