| Full name: protein kinase AMP-activated non-catalytic subunit beta 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.23 | ||
| Entrez ID: 5564 | HGNC ID: HGNC:9378 | Ensembl Gene: ENSG00000111725 | OMIM ID: 602740 |
| Drug and gene relationship at DGIdb | |||
PRKAB1 involved pathways:
Expression of PRKAB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKAB1 | 5564 | 201834_at | -0.7390 | 0.1577 | |
| GSE20347 | PRKAB1 | 5564 | 201834_at | -0.5010 | 0.0001 | |
| GSE23400 | PRKAB1 | 5564 | 201834_at | -0.5425 | 0.0000 | |
| GSE26886 | PRKAB1 | 5564 | 201834_at | -0.9954 | 0.0001 | |
| GSE29001 | PRKAB1 | 5564 | 201834_at | -0.7180 | 0.0014 | |
| GSE38129 | PRKAB1 | 5564 | 201834_at | -0.5332 | 0.0000 | |
| GSE45670 | PRKAB1 | 5564 | 201834_at | -0.4549 | 0.0077 | |
| GSE53622 | PRKAB1 | 5564 | 95940 | -0.3646 | 0.0000 | |
| GSE53624 | PRKAB1 | 5564 | 95940 | -0.7059 | 0.0000 | |
| GSE63941 | PRKAB1 | 5564 | 201834_at | 0.1999 | 0.6067 | |
| GSE77861 | PRKAB1 | 5564 | 201834_at | -0.5037 | 0.0068 | |
| GSE97050 | PRKAB1 | 5564 | A_23_P204503 | -0.3009 | 0.3008 | |
| SRP007169 | PRKAB1 | 5564 | RNAseq | -1.1468 | 0.0027 | |
| SRP008496 | PRKAB1 | 5564 | RNAseq | -1.1425 | 0.0000 | |
| SRP064894 | PRKAB1 | 5564 | RNAseq | -0.6764 | 0.0002 | |
| SRP133303 | PRKAB1 | 5564 | RNAseq | -0.4567 | 0.0035 | |
| SRP159526 | PRKAB1 | 5564 | RNAseq | -0.5291 | 0.0032 | |
| SRP193095 | PRKAB1 | 5564 | RNAseq | -0.5786 | 0.0000 | |
| SRP219564 | PRKAB1 | 5564 | RNAseq | -0.6484 | 0.0163 | |
| TCGA | PRKAB1 | 5564 | RNAseq | -0.4005 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PRKAB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRKAB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKAB1 | 5564 | 6 | 2 | 22 | |
| GSE20123 | PRKAB1 | 5564 | 6 | 2 | 22 | |
| GSE43470 | PRKAB1 | 5564 | 4 | 2 | 37 | |
| GSE46452 | PRKAB1 | 5564 | 9 | 1 | 49 | |
| GSE47630 | PRKAB1 | 5564 | 9 | 3 | 28 | |
| GSE54993 | PRKAB1 | 5564 | 0 | 5 | 65 | |
| GSE54994 | PRKAB1 | 5564 | 6 | 6 | 41 | |
| GSE60625 | PRKAB1 | 5564 | 0 | 0 | 11 | |
| GSE74703 | PRKAB1 | 5564 | 3 | 1 | 32 | |
| GSE74704 | PRKAB1 | 5564 | 3 | 2 | 15 | |
| TCGA | PRKAB1 | 5564 | 21 | 11 | 64 |
Total number of gains: 67; Total number of losses: 35; Total Number of normals: 386.
Somatic mutations of PRKAB1:
Generating mutation plots.
Highly correlated genes for PRKAB1:
Showing top 20/1595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKAB1 | ECD | 0.827827 | 3 | 0 | 3 |
| PRKAB1 | RBM20 | 0.809515 | 4 | 0 | 4 |
| PRKAB1 | KDM3A | 0.782808 | 3 | 0 | 3 |
| PRKAB1 | STOML2 | 0.770913 | 3 | 0 | 3 |
| PRKAB1 | BDH2 | 0.762607 | 3 | 0 | 3 |
| PRKAB1 | GPBP1 | 0.761732 | 3 | 0 | 3 |
| PRKAB1 | HBP1 | 0.754329 | 9 | 0 | 8 |
| PRKAB1 | PLEKHF2 | 0.753401 | 3 | 0 | 3 |
| PRKAB1 | CWC25 | 0.752884 | 3 | 0 | 3 |
| PRKAB1 | COG3 | 0.751687 | 3 | 0 | 3 |
| PRKAB1 | SEC23IP | 0.749071 | 3 | 0 | 3 |
| PRKAB1 | ING4 | 0.740688 | 3 | 0 | 3 |
| PRKAB1 | SNORA68 | 0.738509 | 4 | 0 | 4 |
| PRKAB1 | NDFIP2 | 0.738507 | 3 | 0 | 3 |
| PRKAB1 | PIH1D2 | 0.737476 | 3 | 0 | 3 |
| PRKAB1 | EIF2B1 | 0.734071 | 3 | 0 | 3 |
| PRKAB1 | IMPACT | 0.732251 | 3 | 0 | 3 |
| PRKAB1 | TMEM218 | 0.731445 | 4 | 0 | 3 |
| PRKAB1 | TRIM13 | 0.730682 | 10 | 0 | 10 |
| PRKAB1 | BLOC1S2 | 0.729837 | 3 | 0 | 3 |
For details and further investigation, click here
