| Full name: nuclear receptor coactivator 2 | Alias Symbol: TIF2|GRIP1|NCoA-2|KAT13C|bHLHe75 | ||
| Type: protein-coding gene | Cytoband: 8q13.3 | ||
| Entrez ID: 10499 | HGNC ID: HGNC:7669 | Ensembl Gene: ENSG00000140396 | OMIM ID: 601993 |
| Drug and gene relationship at DGIdb | |||
Expression of NCOA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCOA2 | 10499 | 212867_at | -0.3628 | 0.6072 | |
| GSE20347 | NCOA2 | 10499 | 212867_at | -0.9971 | 0.0002 | |
| GSE23400 | NCOA2 | 10499 | 212867_at | -0.7836 | 0.0000 | |
| GSE26886 | NCOA2 | 10499 | 212867_at | -1.7017 | 0.0000 | |
| GSE29001 | NCOA2 | 10499 | 212867_at | -0.4557 | 0.0719 | |
| GSE38129 | NCOA2 | 10499 | 212867_at | -0.8806 | 0.0001 | |
| GSE45670 | NCOA2 | 10499 | 212867_at | -0.5130 | 0.0036 | |
| GSE53622 | NCOA2 | 10499 | 49105 | -0.6169 | 0.0000 | |
| GSE53624 | NCOA2 | 10499 | 35301 | -1.1946 | 0.0000 | |
| GSE63941 | NCOA2 | 10499 | 212867_at | -0.7456 | 0.1754 | |
| GSE77861 | NCOA2 | 10499 | 212867_at | -1.4459 | 0.0045 | |
| GSE97050 | NCOA2 | 10499 | A_33_P3270019 | -0.2736 | 0.3719 | |
| SRP007169 | NCOA2 | 10499 | RNAseq | -1.1589 | 0.0004 | |
| SRP008496 | NCOA2 | 10499 | RNAseq | -1.0389 | 0.0001 | |
| SRP064894 | NCOA2 | 10499 | RNAseq | -1.1981 | 0.0001 | |
| SRP133303 | NCOA2 | 10499 | RNAseq | -0.8151 | 0.0000 | |
| SRP159526 | NCOA2 | 10499 | RNAseq | -1.4347 | 0.0000 | |
| SRP193095 | NCOA2 | 10499 | RNAseq | -1.0664 | 0.0000 | |
| SRP219564 | NCOA2 | 10499 | RNAseq | -0.9084 | 0.0331 | |
| TCGA | NCOA2 | 10499 | RNAseq | -0.1696 | 0.0252 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by NCOA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NCOA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCOA2 | 10499 | 15 | 1 | 14 | |
| GSE20123 | NCOA2 | 10499 | 16 | 1 | 13 | |
| GSE43470 | NCOA2 | 10499 | 18 | 1 | 24 | |
| GSE46452 | NCOA2 | 10499 | 20 | 2 | 37 | |
| GSE47630 | NCOA2 | 10499 | 23 | 1 | 16 | |
| GSE54993 | NCOA2 | 10499 | 0 | 19 | 51 | |
| GSE54994 | NCOA2 | 10499 | 30 | 1 | 22 | |
| GSE60625 | NCOA2 | 10499 | 0 | 4 | 7 | |
| GSE74703 | NCOA2 | 10499 | 15 | 1 | 20 | |
| GSE74704 | NCOA2 | 10499 | 11 | 0 | 9 | |
| TCGA | NCOA2 | 10499 | 51 | 2 | 43 |
Total number of gains: 199; Total number of losses: 33; Total Number of normals: 256.
Somatic mutations of NCOA2:
Generating mutation plots.
Highly correlated genes for NCOA2:
Showing top 20/1478 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCOA2 | NAA35 | 0.806949 | 3 | 0 | 3 |
| NCOA2 | COG3 | 0.799303 | 3 | 0 | 3 |
| NCOA2 | ETFA | 0.796923 | 3 | 0 | 3 |
| NCOA2 | DUSP16 | 0.767858 | 3 | 0 | 3 |
| NCOA2 | HDHD2 | 0.758308 | 5 | 0 | 5 |
| NCOA2 | FAM214A | 0.757906 | 5 | 0 | 5 |
| NCOA2 | RBM20 | 0.757309 | 5 | 0 | 5 |
| NCOA2 | USP6NL | 0.755978 | 11 | 0 | 11 |
| NCOA2 | CGNL1 | 0.755636 | 6 | 0 | 6 |
| NCOA2 | CCIN | 0.754352 | 4 | 0 | 4 |
| NCOA2 | ZHX1 | 0.753567 | 7 | 0 | 7 |
| NCOA2 | EXOC2 | 0.752812 | 3 | 0 | 3 |
| NCOA2 | ANKRD13A | 0.748306 | 6 | 0 | 5 |
| NCOA2 | HBP1 | 0.746687 | 8 | 0 | 8 |
| NCOA2 | MRPL1 | 0.742998 | 3 | 0 | 3 |
| NCOA2 | USP38 | 0.742028 | 4 | 0 | 3 |
| NCOA2 | STXBP5 | 0.740415 | 7 | 0 | 7 |
| NCOA2 | SPAG17 | 0.740134 | 3 | 0 | 3 |
| NCOA2 | COIL | 0.737729 | 3 | 0 | 3 |
| NCOA2 | TMPRSS11B | 0.737652 | 5 | 0 | 4 |
For details and further investigation, click here
