| Full name: abl interactor 1 | Alias Symbol: E3B1|ABI-1 | ||
| Type: protein-coding gene | Cytoband: 10p12.1 | ||
| Entrez ID: 10006 | HGNC ID: HGNC:11320 | Ensembl Gene: ENSG00000136754 | OMIM ID: 603050 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ABI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABI1 | 10006 | 209027_s_at | -0.5354 | 0.3680 | |
| GSE20347 | ABI1 | 10006 | 209028_s_at | -0.6417 | 0.0003 | |
| GSE23400 | ABI1 | 10006 | 209027_s_at | -0.7068 | 0.0000 | |
| GSE26886 | ABI1 | 10006 | 209028_s_at | -0.3404 | 0.1155 | |
| GSE29001 | ABI1 | 10006 | 209028_s_at | -0.3884 | 0.0869 | |
| GSE38129 | ABI1 | 10006 | 209028_s_at | -0.4064 | 0.0186 | |
| GSE45670 | ABI1 | 10006 | 209027_s_at | -0.2374 | 0.0765 | |
| GSE53622 | ABI1 | 10006 | 84399 | -0.4541 | 0.0001 | |
| GSE53624 | ABI1 | 10006 | 84399 | -0.7202 | 0.0000 | |
| GSE63941 | ABI1 | 10006 | 209027_s_at | 0.9732 | 0.0316 | |
| GSE77861 | ABI1 | 10006 | 209027_s_at | -0.6517 | 0.0327 | |
| GSE97050 | ABI1 | 10006 | A_33_P3622802 | -0.0158 | 0.9626 | |
| SRP007169 | ABI1 | 10006 | RNAseq | -1.5966 | 0.0000 | |
| SRP008496 | ABI1 | 10006 | RNAseq | -1.6068 | 0.0000 | |
| SRP064894 | ABI1 | 10006 | RNAseq | -0.9714 | 0.0000 | |
| SRP133303 | ABI1 | 10006 | RNAseq | -0.4841 | 0.0002 | |
| SRP159526 | ABI1 | 10006 | RNAseq | -1.3837 | 0.0015 | |
| SRP193095 | ABI1 | 10006 | RNAseq | -0.8685 | 0.0000 | |
| SRP219564 | ABI1 | 10006 | RNAseq | -1.0268 | 0.0250 | |
| TCGA | ABI1 | 10006 | RNAseq | 0.1167 | 0.0245 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ABI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABI1 | 10006 | 4 | 7 | 19 | |
| GSE20123 | ABI1 | 10006 | 5 | 6 | 19 | |
| GSE43470 | ABI1 | 10006 | 3 | 4 | 36 | |
| GSE46452 | ABI1 | 10006 | 1 | 14 | 44 | |
| GSE47630 | ABI1 | 10006 | 5 | 15 | 20 | |
| GSE54993 | ABI1 | 10006 | 9 | 0 | 61 | |
| GSE54994 | ABI1 | 10006 | 3 | 9 | 41 | |
| GSE60625 | ABI1 | 10006 | 0 | 0 | 11 | |
| GSE74703 | ABI1 | 10006 | 2 | 2 | 32 | |
| GSE74704 | ABI1 | 10006 | 0 | 5 | 15 | |
| TCGA | ABI1 | 10006 | 18 | 25 | 53 |
Total number of gains: 50; Total number of losses: 87; Total Number of normals: 351.
Somatic mutations of ABI1:
Generating mutation plots.
Highly correlated genes for ABI1:
Showing top 20/1227 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABI1 | SLC35E3 | 0.817685 | 3 | 0 | 3 |
| ABI1 | SNX33 | 0.805622 | 3 | 0 | 3 |
| ABI1 | DNAJC19 | 0.775371 | 3 | 0 | 3 |
| ABI1 | EIF4E2 | 0.770795 | 3 | 0 | 3 |
| ABI1 | BCL10 | 0.75242 | 8 | 0 | 8 |
| ABI1 | AP3M1 | 0.747756 | 3 | 0 | 3 |
| ABI1 | NRBF2 | 0.740809 | 3 | 0 | 3 |
| ABI1 | COG3 | 0.740237 | 3 | 0 | 3 |
| ABI1 | CTTNBP2NL | 0.738622 | 7 | 0 | 7 |
| ABI1 | ZCCHC9 | 0.73144 | 4 | 0 | 4 |
| ABI1 | ESYT2 | 0.731121 | 4 | 0 | 4 |
| ABI1 | ZNF70 | 0.729662 | 3 | 0 | 3 |
| ABI1 | UBR3 | 0.726868 | 3 | 0 | 3 |
| ABI1 | BLOC1S2 | 0.726469 | 6 | 0 | 6 |
| ABI1 | RNF183 | 0.722281 | 3 | 0 | 3 |
| ABI1 | STYX | 0.711489 | 3 | 0 | 3 |
| ABI1 | RBAK | 0.708626 | 4 | 0 | 3 |
| ABI1 | MBD2 | 0.708321 | 9 | 0 | 8 |
| ABI1 | DNAJB12 | 0.7062 | 3 | 0 | 3 |
| ABI1 | SSU72 | 0.704338 | 4 | 0 | 4 |
For details and further investigation, click here
