| Full name: mitochondrial ribosomal protein S34 | Alias Symbol: MRP-S12|MGC2616 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 65993 | HGNC ID: HGNC:16618 | Ensembl Gene: ENSG00000074071 | OMIM ID: 611994 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPS34:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS34 | 65993 | 218112_at | 0.5381 | 0.1823 | |
| GSE20347 | MRPS34 | 65993 | 218112_at | 0.2901 | 0.0231 | |
| GSE23400 | MRPS34 | 65993 | 218112_at | 0.3445 | 0.0000 | |
| GSE26886 | MRPS34 | 65993 | 218112_at | 0.3419 | 0.0262 | |
| GSE29001 | MRPS34 | 65993 | 218112_at | 0.4045 | 0.2098 | |
| GSE38129 | MRPS34 | 65993 | 218112_at | 0.4589 | 0.0001 | |
| GSE45670 | MRPS34 | 65993 | 218112_at | 0.3784 | 0.0032 | |
| GSE53622 | MRPS34 | 65993 | 146100 | 0.3919 | 0.0000 | |
| GSE53624 | MRPS34 | 65993 | 146100 | 0.5051 | 0.0000 | |
| GSE63941 | MRPS34 | 65993 | 218112_at | 0.7084 | 0.0104 | |
| GSE77861 | MRPS34 | 65993 | 218112_at | 0.2789 | 0.1579 | |
| GSE97050 | MRPS34 | 65993 | A_33_P3422931 | 0.3058 | 0.3542 | |
| SRP007169 | MRPS34 | 65993 | RNAseq | -0.2528 | 0.3858 | |
| SRP008496 | MRPS34 | 65993 | RNAseq | -0.2465 | 0.3229 | |
| SRP064894 | MRPS34 | 65993 | RNAseq | 0.4166 | 0.2050 | |
| SRP133303 | MRPS34 | 65993 | RNAseq | 0.4893 | 0.0023 | |
| SRP159526 | MRPS34 | 65993 | RNAseq | 0.3399 | 0.1939 | |
| SRP193095 | MRPS34 | 65993 | RNAseq | 0.0962 | 0.4381 | |
| SRP219564 | MRPS34 | 65993 | RNAseq | 0.6353 | 0.0971 | |
| TCGA | MRPS34 | 65993 | RNAseq | 0.1438 | 0.0188 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MRPS34 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS34:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS34 | 65993 | 5 | 5 | 20 | |
| GSE20123 | MRPS34 | 65993 | 5 | 4 | 21 | |
| GSE43470 | MRPS34 | 65993 | 4 | 7 | 32 | |
| GSE46452 | MRPS34 | 65993 | 38 | 1 | 20 | |
| GSE47630 | MRPS34 | 65993 | 13 | 6 | 21 | |
| GSE54993 | MRPS34 | 65993 | 3 | 5 | 62 | |
| GSE54994 | MRPS34 | 65993 | 6 | 8 | 39 | |
| GSE60625 | MRPS34 | 65993 | 4 | 0 | 7 | |
| GSE74703 | MRPS34 | 65993 | 4 | 5 | 27 | |
| GSE74704 | MRPS34 | 65993 | 3 | 2 | 15 | |
| TCGA | MRPS34 | 65993 | 19 | 14 | 63 |
Total number of gains: 104; Total number of losses: 57; Total Number of normals: 327.
Somatic mutations of MRPS34:
Generating mutation plots.
Highly correlated genes for MRPS34:
Showing top 20/1462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS34 | KTI12 | 0.795572 | 3 | 0 | 3 |
| MRPS34 | ATG4C | 0.788794 | 3 | 0 | 3 |
| MRPS34 | IRF2BPL | 0.768393 | 3 | 0 | 3 |
| MRPS34 | MRPL38 | 0.760817 | 5 | 0 | 5 |
| MRPS34 | SPNS1 | 0.757992 | 5 | 0 | 4 |
| MRPS34 | ZDHHC16 | 0.741076 | 5 | 0 | 5 |
| MRPS34 | SLC39A3 | 0.736691 | 3 | 0 | 3 |
| MRPS34 | TMEM54 | 0.732477 | 4 | 0 | 4 |
| MRPS34 | ELOF1 | 0.732388 | 6 | 0 | 6 |
| MRPS34 | EARS2 | 0.731426 | 6 | 0 | 5 |
| MRPS34 | TTC39C | 0.730196 | 3 | 0 | 3 |
| MRPS34 | RNF26 | 0.728889 | 5 | 0 | 5 |
| MRPS34 | PSMG3 | 0.727773 | 7 | 0 | 6 |
| MRPS34 | CDT1 | 0.725579 | 11 | 0 | 11 |
| MRPS34 | FBXO16 | 0.725404 | 3 | 0 | 3 |
| MRPS34 | GTPBP10 | 0.722735 | 3 | 0 | 3 |
| MRPS34 | COQ4 | 0.721327 | 3 | 0 | 3 |
| MRPS34 | C3orf33 | 0.717668 | 4 | 0 | 4 |
| MRPS34 | CCP110 | 0.715813 | 3 | 0 | 3 |
| MRPS34 | CCNF | 0.714871 | 10 | 0 | 10 |
For details and further investigation, click here
