| Full name: cytochrome c oxidase subunit 4I1 | Alias Symbol: COX4-1 | ||
| Type: protein-coding gene | Cytoband: 16q24.1 | ||
| Entrez ID: 1327 | HGNC ID: HGNC:2265 | Ensembl Gene: ENSG00000131143 | OMIM ID: 123864 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX4I1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX4I1 | 1327 | 202698_x_at | 0.0392 | 0.8932 | |
| GSE20347 | COX4I1 | 1327 | 202698_x_at | -0.1854 | 0.0259 | |
| GSE23400 | COX4I1 | 1327 | 202698_x_at | -0.1555 | 0.0068 | |
| GSE26886 | COX4I1 | 1327 | 202698_x_at | -0.2312 | 0.1775 | |
| GSE29001 | COX4I1 | 1327 | 202698_x_at | -0.4206 | 0.1123 | |
| GSE38129 | COX4I1 | 1327 | 202698_x_at | -0.1683 | 0.0421 | |
| GSE45670 | COX4I1 | 1327 | 202698_x_at | -0.2062 | 0.1358 | |
| GSE53622 | COX4I1 | 1327 | 144236 | -0.4445 | 0.0000 | |
| GSE53624 | COX4I1 | 1327 | 144236 | -0.1664 | 0.0028 | |
| GSE63941 | COX4I1 | 1327 | 202698_x_at | 0.2924 | 0.2572 | |
| GSE77861 | COX4I1 | 1327 | 202698_x_at | 0.1290 | 0.5071 | |
| GSE97050 | COX4I1 | 1327 | A_23_P141032 | -0.3865 | 0.1279 | |
| SRP007169 | COX4I1 | 1327 | RNAseq | 0.3914 | 0.3642 | |
| SRP008496 | COX4I1 | 1327 | RNAseq | 0.4314 | 0.1415 | |
| SRP064894 | COX4I1 | 1327 | RNAseq | -0.2787 | 0.4042 | |
| SRP133303 | COX4I1 | 1327 | RNAseq | -0.0777 | 0.5993 | |
| SRP159526 | COX4I1 | 1327 | RNAseq | -0.0768 | 0.8424 | |
| SRP193095 | COX4I1 | 1327 | RNAseq | -0.7031 | 0.0000 | |
| SRP219564 | COX4I1 | 1327 | RNAseq | -0.4724 | 0.1738 | |
| TCGA | COX4I1 | 1327 | RNAseq | -0.1313 | 0.0065 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by COX4I1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COX4I1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX4I1 | 1327 | 4 | 4 | 22 | |
| GSE20123 | COX4I1 | 1327 | 4 | 4 | 22 | |
| GSE43470 | COX4I1 | 1327 | 2 | 10 | 31 | |
| GSE46452 | COX4I1 | 1327 | 37 | 2 | 20 | |
| GSE47630 | COX4I1 | 1327 | 11 | 9 | 20 | |
| GSE54993 | COX4I1 | 1327 | 3 | 4 | 63 | |
| GSE54994 | COX4I1 | 1327 | 9 | 10 | 34 | |
| GSE60625 | COX4I1 | 1327 | 4 | 0 | 7 | |
| GSE74703 | COX4I1 | 1327 | 1 | 7 | 28 | |
| GSE74704 | COX4I1 | 1327 | 3 | 2 | 15 | |
| TCGA | COX4I1 | 1327 | 26 | 16 | 54 |
Total number of gains: 104; Total number of losses: 68; Total Number of normals: 316.
Somatic mutations of COX4I1:
Generating mutation plots.
Highly correlated genes for COX4I1:
Showing top 20/426 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX4I1 | TCEANC2 | 0.732204 | 3 | 0 | 3 |
| COX4I1 | ZFAND6 | 0.723817 | 3 | 0 | 3 |
| COX4I1 | DDX19A | 0.723088 | 4 | 0 | 3 |
| COX4I1 | C1orf226 | 0.722986 | 3 | 0 | 3 |
| COX4I1 | FAM174A | 0.715468 | 3 | 0 | 3 |
| COX4I1 | MLST8 | 0.710648 | 3 | 0 | 3 |
| COX4I1 | DHX38 | 0.700925 | 4 | 0 | 4 |
| COX4I1 | CHCHD2 | 0.700876 | 4 | 0 | 3 |
| COX4I1 | POLR2C | 0.697122 | 7 | 0 | 6 |
| COX4I1 | OSBPL2 | 0.693126 | 3 | 0 | 3 |
| COX4I1 | PARP4 | 0.689093 | 3 | 0 | 3 |
| COX4I1 | DPY30 | 0.686067 | 3 | 0 | 3 |
| COX4I1 | TCF25 | 0.673057 | 3 | 0 | 3 |
| COX4I1 | RBM27 | 0.671553 | 3 | 0 | 3 |
| COX4I1 | CRK | 0.670964 | 3 | 0 | 3 |
| COX4I1 | FDPS | 0.669051 | 3 | 0 | 3 |
| COX4I1 | SF3A1 | 0.668159 | 4 | 0 | 4 |
| COX4I1 | AIP | 0.666652 | 3 | 0 | 3 |
| COX4I1 | ZCCHC10 | 0.666248 | 3 | 0 | 3 |
| COX4I1 | TMEM219 | 0.66378 | 3 | 0 | 3 |
For details and further investigation, click here
