| Full name: MTOR associated protein, LST8 homolog | Alias Symbol: Lst8|Pop3|GBL|GbetaL | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 64223 | HGNC ID: HGNC:24825 | Ensembl Gene: ENSG00000167965 | OMIM ID: 612190 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MLST8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04150 | mTOR signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of MLST8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLST8 | 64223 | 220587_s_at | 0.1893 | 0.6084 | |
| GSE20347 | MLST8 | 64223 | 220587_s_at | 0.3459 | 0.0038 | |
| GSE23400 | MLST8 | 64223 | 220587_s_at | 0.1758 | 0.0013 | |
| GSE26886 | MLST8 | 64223 | 220587_s_at | 0.1413 | 0.2603 | |
| GSE29001 | MLST8 | 64223 | 220587_s_at | 0.2111 | 0.2767 | |
| GSE38129 | MLST8 | 64223 | 220587_s_at | 0.3764 | 0.0000 | |
| GSE45670 | MLST8 | 64223 | 220587_s_at | 0.3738 | 0.0016 | |
| GSE53622 | MLST8 | 64223 | 45726 | 0.3953 | 0.0000 | |
| GSE53624 | MLST8 | 64223 | 45726 | 0.2118 | 0.0008 | |
| GSE63941 | MLST8 | 64223 | 220587_s_at | 0.4578 | 0.0853 | |
| GSE77861 | MLST8 | 64223 | 220587_s_at | -0.1059 | 0.4450 | |
| GSE97050 | MLST8 | 64223 | A_33_P3276519 | 0.1961 | 0.5057 | |
| SRP007169 | MLST8 | 64223 | RNAseq | 0.0480 | 0.9065 | |
| SRP008496 | MLST8 | 64223 | RNAseq | -0.1156 | 0.6625 | |
| SRP064894 | MLST8 | 64223 | RNAseq | 0.3779 | 0.1763 | |
| SRP133303 | MLST8 | 64223 | RNAseq | 0.3184 | 0.1256 | |
| SRP159526 | MLST8 | 64223 | RNAseq | 0.1749 | 0.3886 | |
| SRP193095 | MLST8 | 64223 | RNAseq | -0.0419 | 0.7696 | |
| SRP219564 | MLST8 | 64223 | RNAseq | 0.5289 | 0.0747 | |
| TCGA | MLST8 | 64223 | RNAseq | 0.0916 | 0.1072 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MLST8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLST8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLST8 | 64223 | 5 | 5 | 20 | |
| GSE20123 | MLST8 | 64223 | 5 | 4 | 21 | |
| GSE43470 | MLST8 | 64223 | 4 | 7 | 32 | |
| GSE46452 | MLST8 | 64223 | 38 | 1 | 20 | |
| GSE47630 | MLST8 | 64223 | 13 | 6 | 21 | |
| GSE54993 | MLST8 | 64223 | 3 | 5 | 62 | |
| GSE54994 | MLST8 | 64223 | 5 | 9 | 39 | |
| GSE60625 | MLST8 | 64223 | 4 | 0 | 7 | |
| GSE74703 | MLST8 | 64223 | 4 | 5 | 27 | |
| GSE74704 | MLST8 | 64223 | 3 | 2 | 15 | |
| TCGA | MLST8 | 64223 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of MLST8:
Generating mutation plots.
Highly correlated genes for MLST8:
Showing top 20/765 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLST8 | RNF26 | 0.806575 | 3 | 0 | 3 |
| MLST8 | LCMT2 | 0.735181 | 3 | 0 | 3 |
| MLST8 | TRAF7 | 0.732902 | 4 | 0 | 4 |
| MLST8 | HSD17B10 | 0.715697 | 3 | 0 | 3 |
| MLST8 | COX4I1 | 0.710648 | 3 | 0 | 3 |
| MLST8 | COX5A | 0.706005 | 3 | 0 | 3 |
| MLST8 | CDKN2D | 0.704225 | 3 | 0 | 3 |
| MLST8 | MRPS34 | 0.699144 | 11 | 0 | 9 |
| MLST8 | ALG1 | 0.698952 | 3 | 0 | 3 |
| MLST8 | EMG1 | 0.697396 | 7 | 0 | 7 |
| MLST8 | SPNS1 | 0.694813 | 4 | 0 | 3 |
| MLST8 | AIFM1 | 0.692764 | 7 | 0 | 6 |
| MLST8 | SKA1 | 0.690468 | 6 | 0 | 6 |
| MLST8 | RNPS1 | 0.686749 | 9 | 0 | 8 |
| MLST8 | USP42 | 0.683705 | 4 | 0 | 4 |
| MLST8 | PRELID1 | 0.679182 | 3 | 0 | 3 |
| MLST8 | PPP1R9B | 0.678987 | 3 | 0 | 3 |
| MLST8 | MEAF6 | 0.676724 | 3 | 0 | 3 |
| MLST8 | YLPM1 | 0.676347 | 4 | 0 | 3 |
| MLST8 | EEFSEC | 0.67537 | 4 | 0 | 4 |
For details and further investigation, click here
