| Full name: oxysterol binding protein like 2 | Alias Symbol: KIAA0772|ORP-2|DFNA67 | ||
| Type: protein-coding gene | Cytoband: 20q13.33 | ||
| Entrez ID: 9885 | HGNC ID: HGNC:15761 | Ensembl Gene: ENSG00000130703 | OMIM ID: 606731 |
| Drug and gene relationship at DGIdb | |||
Expression of OSBPL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSBPL2 | 9885 | 209222_s_at | 0.0154 | 0.9879 | |
| GSE20347 | OSBPL2 | 9885 | 209222_s_at | -0.6080 | 0.0003 | |
| GSE23400 | OSBPL2 | 9885 | 209222_s_at | -0.5203 | 0.0000 | |
| GSE26886 | OSBPL2 | 9885 | 209222_s_at | -1.6543 | 0.0000 | |
| GSE29001 | OSBPL2 | 9885 | 209222_s_at | -0.3623 | 0.2474 | |
| GSE38129 | OSBPL2 | 9885 | 209222_s_at | -0.4165 | 0.0122 | |
| GSE45670 | OSBPL2 | 9885 | 209222_s_at | -0.0265 | 0.8996 | |
| GSE53622 | OSBPL2 | 9885 | 18402 | -0.8999 | 0.0000 | |
| GSE53624 | OSBPL2 | 9885 | 18402 | -0.8727 | 0.0000 | |
| GSE63941 | OSBPL2 | 9885 | 209222_s_at | 0.7877 | 0.0954 | |
| GSE77861 | OSBPL2 | 9885 | 209222_s_at | -0.5608 | 0.0957 | |
| GSE97050 | OSBPL2 | 9885 | A_33_P3381827 | 0.0066 | 0.9821 | |
| SRP007169 | OSBPL2 | 9885 | RNAseq | -1.9270 | 0.0000 | |
| SRP008496 | OSBPL2 | 9885 | RNAseq | -1.7322 | 0.0000 | |
| SRP064894 | OSBPL2 | 9885 | RNAseq | -0.7080 | 0.0000 | |
| SRP133303 | OSBPL2 | 9885 | RNAseq | -0.5362 | 0.0000 | |
| SRP159526 | OSBPL2 | 9885 | RNAseq | -0.9376 | 0.0015 | |
| SRP193095 | OSBPL2 | 9885 | RNAseq | -0.7833 | 0.0000 | |
| SRP219564 | OSBPL2 | 9885 | RNAseq | -0.5882 | 0.0861 | |
| TCGA | OSBPL2 | 9885 | RNAseq | -0.1424 | 0.0026 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by OSBPL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSBPL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSBPL2 | 9885 | 13 | 2 | 15 | |
| GSE20123 | OSBPL2 | 9885 | 14 | 2 | 14 | |
| GSE43470 | OSBPL2 | 9885 | 11 | 1 | 31 | |
| GSE46452 | OSBPL2 | 9885 | 35 | 0 | 24 | |
| GSE47630 | OSBPL2 | 9885 | 25 | 1 | 14 | |
| GSE54993 | OSBPL2 | 9885 | 0 | 17 | 53 | |
| GSE54994 | OSBPL2 | 9885 | 29 | 0 | 24 | |
| GSE60625 | OSBPL2 | 9885 | 0 | 0 | 11 | |
| GSE74703 | OSBPL2 | 9885 | 10 | 0 | 26 | |
| GSE74704 | OSBPL2 | 9885 | 11 | 0 | 9 | |
| TCGA | OSBPL2 | 9885 | 43 | 4 | 49 |
Total number of gains: 191; Total number of losses: 27; Total Number of normals: 270.
Somatic mutations of OSBPL2:
Generating mutation plots.
Highly correlated genes for OSBPL2:
Showing top 20/1444 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSBPL2 | ALKBH3 | 0.791784 | 3 | 0 | 3 |
| OSBPL2 | GRPEL1 | 0.787695 | 3 | 0 | 3 |
| OSBPL2 | LYRM7 | 0.781713 | 3 | 0 | 3 |
| OSBPL2 | TMEM167A | 0.779239 | 3 | 0 | 3 |
| OSBPL2 | KIN | 0.778968 | 3 | 0 | 3 |
| OSBPL2 | HDHD2 | 0.775957 | 4 | 0 | 4 |
| OSBPL2 | UQCRC2 | 0.766536 | 4 | 0 | 4 |
| OSBPL2 | SRD5A3 | 0.766476 | 3 | 0 | 3 |
| OSBPL2 | PCBP1-AS1 | 0.757476 | 3 | 0 | 3 |
| OSBPL2 | SLC10A7 | 0.753943 | 4 | 0 | 4 |
| OSBPL2 | TBCA | 0.747168 | 3 | 0 | 3 |
| OSBPL2 | PRADC1 | 0.745933 | 4 | 0 | 4 |
| OSBPL2 | TMEM50A | 0.736597 | 3 | 0 | 3 |
| OSBPL2 | NIPBL | 0.736314 | 4 | 0 | 4 |
| OSBPL2 | TRNP1 | 0.734708 | 5 | 0 | 5 |
| OSBPL2 | TMEM186 | 0.731092 | 4 | 0 | 3 |
| OSBPL2 | RAB11A | 0.730621 | 10 | 0 | 10 |
| OSBPL2 | MCTS1 | 0.728667 | 3 | 0 | 3 |
| OSBPL2 | ERI2 | 0.726813 | 3 | 0 | 3 |
| OSBPL2 | TAB3 | 0.724449 | 6 | 0 | 5 |
For details and further investigation, click here
