| Full name: RNA polymerase II subunit C | Alias Symbol: RPB3 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 5432 | HGNC ID: HGNC:9189 | Ensembl Gene: ENSG00000102978 | OMIM ID: 180663 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2C | 5432 | 208996_s_at | 0.1532 | 0.7760 | |
| GSE20347 | POLR2C | 5432 | 208996_s_at | 0.4210 | 0.0318 | |
| GSE23400 | POLR2C | 5432 | 208996_s_at | 0.2015 | 0.0000 | |
| GSE26886 | POLR2C | 5432 | 208996_s_at | -0.5445 | 0.0099 | |
| GSE29001 | POLR2C | 5432 | 208996_s_at | -0.0545 | 0.7887 | |
| GSE38129 | POLR2C | 5432 | 214263_x_at | 0.4141 | 0.0003 | |
| GSE45670 | POLR2C | 5432 | 214263_x_at | 0.2074 | 0.0605 | |
| GSE53622 | POLR2C | 5432 | 108128 | 0.3633 | 0.0000 | |
| GSE53624 | POLR2C | 5432 | 108128 | 0.3544 | 0.0000 | |
| GSE63941 | POLR2C | 5432 | 208996_s_at | 0.8479 | 0.0080 | |
| GSE77861 | POLR2C | 5432 | 208996_s_at | 0.3452 | 0.1165 | |
| GSE97050 | POLR2C | 5432 | A_23_P3527 | 0.1382 | 0.6004 | |
| SRP007169 | POLR2C | 5432 | RNAseq | 0.1516 | 0.6242 | |
| SRP008496 | POLR2C | 5432 | RNAseq | 0.0690 | 0.7653 | |
| SRP064894 | POLR2C | 5432 | RNAseq | -0.0535 | 0.7214 | |
| SRP133303 | POLR2C | 5432 | RNAseq | 0.4626 | 0.0012 | |
| SRP159526 | POLR2C | 5432 | RNAseq | 0.5562 | 0.0000 | |
| SRP193095 | POLR2C | 5432 | RNAseq | 0.1223 | 0.2552 | |
| SRP219564 | POLR2C | 5432 | RNAseq | 0.0659 | 0.8302 | |
| TCGA | POLR2C | 5432 | RNAseq | 0.0622 | 0.2041 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLR2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2C | 5432 | 6 | 0 | 24 | |
| GSE20123 | POLR2C | 5432 | 6 | 1 | 23 | |
| GSE43470 | POLR2C | 5432 | 3 | 5 | 35 | |
| GSE46452 | POLR2C | 5432 | 38 | 1 | 20 | |
| GSE47630 | POLR2C | 5432 | 10 | 8 | 22 | |
| GSE54993 | POLR2C | 5432 | 2 | 4 | 64 | |
| GSE54994 | POLR2C | 5432 | 7 | 10 | 36 | |
| GSE60625 | POLR2C | 5432 | 4 | 0 | 7 | |
| GSE74703 | POLR2C | 5432 | 3 | 3 | 30 | |
| GSE74704 | POLR2C | 5432 | 5 | 0 | 15 | |
| TCGA | POLR2C | 5432 | 26 | 12 | 58 |
Total number of gains: 110; Total number of losses: 44; Total Number of normals: 334.
Somatic mutations of POLR2C:
Generating mutation plots.
Highly correlated genes for POLR2C:
Showing top 20/809 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2C | GTF2B | 0.824471 | 3 | 0 | 3 |
| POLR2C | ZNF343 | 0.814733 | 3 | 0 | 3 |
| POLR2C | ANKRD40 | 0.73844 | 3 | 0 | 3 |
| POLR2C | CSNK2B | 0.732655 | 4 | 0 | 4 |
| POLR2C | TSEN15 | 0.720815 | 3 | 0 | 3 |
| POLR2C | TMCO6 | 0.719796 | 3 | 0 | 3 |
| POLR2C | IRAK2 | 0.714326 | 3 | 0 | 3 |
| POLR2C | PIAS2 | 0.713415 | 3 | 0 | 3 |
| POLR2C | NFKB1 | 0.713119 | 5 | 0 | 4 |
| POLR2C | TP53RK | 0.71286 | 3 | 0 | 3 |
| POLR2C | CNOT1 | 0.708707 | 5 | 0 | 4 |
| POLR2C | ZC3H18 | 0.707856 | 4 | 0 | 4 |
| POLR2C | GCLC | 0.702919 | 4 | 0 | 3 |
| POLR2C | NUP50 | 0.701853 | 4 | 0 | 3 |
| POLR2C | COX4I1 | 0.697122 | 7 | 0 | 6 |
| POLR2C | AGFG1 | 0.696486 | 3 | 0 | 3 |
| POLR2C | FAM192A | 0.692659 | 8 | 0 | 6 |
| POLR2C | COMMD3 | 0.692341 | 3 | 0 | 3 |
| POLR2C | RIOK2 | 0.691396 | 3 | 0 | 3 |
| POLR2C | NOB1 | 0.68823 | 5 | 0 | 4 |
For details and further investigation, click here
