| Full name: carboxypeptidase A3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q24 | ||
| Entrez ID: 1359 | HGNC ID: HGNC:2298 | Ensembl Gene: ENSG00000163751 | OMIM ID: 114851 |
| Drug and gene relationship at DGIdb | |||
Expression of CPA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPA3 | 1359 | 205624_at | -1.4573 | 0.4296 | |
| GSE20347 | CPA3 | 1359 | 205624_at | -0.5825 | 0.0551 | |
| GSE23400 | CPA3 | 1359 | 205624_at | -0.1425 | 0.2239 | |
| GSE26886 | CPA3 | 1359 | 205624_at | -1.2163 | 0.0743 | |
| GSE29001 | CPA3 | 1359 | 205624_at | -0.6416 | 0.0585 | |
| GSE38129 | CPA3 | 1359 | 205624_at | -0.7837 | 0.0586 | |
| GSE45670 | CPA3 | 1359 | 205624_at | -1.5117 | 0.0236 | |
| GSE53622 | CPA3 | 1359 | 83872 | -1.2955 | 0.0000 | |
| GSE53624 | CPA3 | 1359 | 83872 | -1.4282 | 0.0000 | |
| GSE63941 | CPA3 | 1359 | 205624_at | -0.0266 | 0.8858 | |
| GSE77861 | CPA3 | 1359 | 205624_at | 0.3973 | 0.6203 | |
| GSE97050 | CPA3 | 1359 | A_23_P18017 | 0.0608 | 0.8945 | |
| SRP007169 | CPA3 | 1359 | RNAseq | -0.9113 | 0.0355 | |
| SRP008496 | CPA3 | 1359 | RNAseq | 0.5907 | 0.2250 | |
| SRP064894 | CPA3 | 1359 | RNAseq | -0.6905 | 0.1833 | |
| SRP133303 | CPA3 | 1359 | RNAseq | -1.4912 | 0.0009 | |
| SRP159526 | CPA3 | 1359 | RNAseq | 1.0809 | 0.3228 | |
| SRP193095 | CPA3 | 1359 | RNAseq | 0.1054 | 0.7741 | |
| SRP219564 | CPA3 | 1359 | RNAseq | 0.7432 | 0.4037 | |
| TCGA | CPA3 | 1359 | RNAseq | -0.7206 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by CPA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPA3 | 1359 | 22 | 0 | 8 | |
| GSE20123 | CPA3 | 1359 | 22 | 0 | 8 | |
| GSE43470 | CPA3 | 1359 | 23 | 0 | 20 | |
| GSE46452 | CPA3 | 1359 | 18 | 2 | 39 | |
| GSE47630 | CPA3 | 1359 | 19 | 3 | 18 | |
| GSE54993 | CPA3 | 1359 | 1 | 10 | 59 | |
| GSE54994 | CPA3 | 1359 | 35 | 1 | 17 | |
| GSE60625 | CPA3 | 1359 | 0 | 6 | 5 | |
| GSE74703 | CPA3 | 1359 | 20 | 0 | 16 | |
| GSE74704 | CPA3 | 1359 | 15 | 0 | 5 | |
| TCGA | CPA3 | 1359 | 71 | 1 | 24 |
Total number of gains: 246; Total number of losses: 23; Total Number of normals: 219.
Somatic mutations of CPA3:
Generating mutation plots.
Highly correlated genes for CPA3:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPA3 | GIMAP5 | 0.794518 | 3 | 0 | 3 |
| CPA3 | TPSB2 | 0.781886 | 9 | 0 | 9 |
| CPA3 | TPSAB1 | 0.78061 | 8 | 0 | 8 |
| CPA3 | IRAK3 | 0.762802 | 4 | 0 | 4 |
| CPA3 | DCTD | 0.757085 | 3 | 0 | 3 |
| CPA3 | WDR61 | 0.753481 | 3 | 0 | 3 |
| CPA3 | PPIL3 | 0.74963 | 3 | 0 | 3 |
| CPA3 | CLC | 0.73625 | 3 | 0 | 3 |
| CPA3 | SLC18A2 | 0.725012 | 10 | 0 | 9 |
| CPA3 | MMRN1 | 0.71481 | 8 | 0 | 8 |
| CPA3 | MTM1 | 0.714747 | 3 | 0 | 3 |
| CPA3 | P2RY13 | 0.71137 | 8 | 0 | 7 |
| CPA3 | LANCL1 | 0.70761 | 3 | 0 | 3 |
| CPA3 | MPEG1 | 0.705632 | 6 | 0 | 6 |
| CPA3 | MRPL44 | 0.704769 | 3 | 0 | 3 |
| CPA3 | COPS4 | 0.701718 | 3 | 0 | 3 |
| CPA3 | ZDHHC2 | 0.698735 | 3 | 0 | 3 |
| CPA3 | CNRIP1 | 0.698046 | 6 | 0 | 6 |
| CPA3 | TYW3 | 0.697092 | 4 | 0 | 4 |
| CPA3 | FAM162B | 0.696072 | 6 | 0 | 6 |
For details and further investigation, click here
