| Full name: interleukin 1 receptor associated kinase 3 | Alias Symbol: IRAK-M | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 11213 | HGNC ID: HGNC:17020 | Ensembl Gene: ENSG00000090376 | OMIM ID: 604459 |
IRAK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway |
Expression of IRAK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRAK3 | 11213 | 213817_at | -0.0632 | 0.9691 | |
| GSE20347 | IRAK3 | 11213 | 220034_at | -0.0264 | 0.7205 | |
| GSE23400 | IRAK3 | 11213 | 220034_at | -0.0014 | 0.9691 | |
| GSE26886 | IRAK3 | 11213 | 220034_at | 0.4657 | 0.0031 | |
| GSE29001 | IRAK3 | 11213 | 220034_at | 0.1260 | 0.5441 | |
| GSE38129 | IRAK3 | 11213 | 220034_at | -0.1329 | 0.2246 | |
| GSE45670 | IRAK3 | 11213 | 213817_at | -1.4414 | 0.0008 | |
| GSE53622 | IRAK3 | 11213 | 12129 | -0.1245 | 0.4002 | |
| GSE53624 | IRAK3 | 11213 | 23447 | -0.2684 | 0.0006 | |
| GSE63941 | IRAK3 | 11213 | 220034_at | -1.1339 | 0.0055 | |
| GSE77861 | IRAK3 | 11213 | 1568830_at | 0.0069 | 0.9397 | |
| GSE97050 | IRAK3 | 11213 | A_23_P162300 | 0.3119 | 0.2709 | |
| SRP007169 | IRAK3 | 11213 | RNAseq | 1.6635 | 0.0026 | |
| SRP008496 | IRAK3 | 11213 | RNAseq | 1.3664 | 0.0005 | |
| SRP064894 | IRAK3 | 11213 | RNAseq | 0.5769 | 0.1100 | |
| SRP133303 | IRAK3 | 11213 | RNAseq | 0.1221 | 0.7134 | |
| SRP159526 | IRAK3 | 11213 | RNAseq | -0.0229 | 0.9586 | |
| SRP193095 | IRAK3 | 11213 | RNAseq | 0.4633 | 0.1074 | |
| SRP219564 | IRAK3 | 11213 | RNAseq | 0.6855 | 0.0170 | |
| TCGA | IRAK3 | 11213 | RNAseq | -0.5848 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by IRAK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRAK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRAK3 | 11213 | 5 | 1 | 24 | |
| GSE20123 | IRAK3 | 11213 | 5 | 1 | 24 | |
| GSE43470 | IRAK3 | 11213 | 5 | 0 | 38 | |
| GSE46452 | IRAK3 | 11213 | 13 | 0 | 46 | |
| GSE47630 | IRAK3 | 11213 | 10 | 1 | 29 | |
| GSE54993 | IRAK3 | 11213 | 0 | 7 | 63 | |
| GSE54994 | IRAK3 | 11213 | 6 | 1 | 46 | |
| GSE60625 | IRAK3 | 11213 | 0 | 0 | 11 | |
| GSE74703 | IRAK3 | 11213 | 5 | 0 | 31 | |
| GSE74704 | IRAK3 | 11213 | 4 | 1 | 15 | |
| TCGA | IRAK3 | 11213 | 24 | 9 | 63 |
Total number of gains: 77; Total number of losses: 21; Total Number of normals: 390.
Somatic mutations of IRAK3:
Generating mutation plots.
Highly correlated genes for IRAK3:
Showing top 20/698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRAK3 | HAUS1 | 0.835978 | 3 | 0 | 3 |
| IRAK3 | MEX3C | 0.768756 | 3 | 0 | 3 |
| IRAK3 | ANGPTL2 | 0.764838 | 5 | 0 | 5 |
| IRAK3 | CPA3 | 0.762802 | 4 | 0 | 4 |
| IRAK3 | ACVR1 | 0.76182 | 3 | 0 | 3 |
| IRAK3 | MRVI1 | 0.751362 | 3 | 0 | 3 |
| IRAK3 | MCAM | 0.745285 | 5 | 0 | 5 |
| IRAK3 | LRRCC1 | 0.740448 | 3 | 0 | 3 |
| IRAK3 | FGF7 | 0.732557 | 5 | 0 | 4 |
| IRAK3 | KANK4 | 0.72783 | 3 | 0 | 3 |
| IRAK3 | SLC1A1 | 0.72656 | 3 | 0 | 3 |
| IRAK3 | ARHGAP31 | 0.725291 | 5 | 0 | 4 |
| IRAK3 | SGIP1 | 0.725137 | 3 | 0 | 3 |
| IRAK3 | ASPA | 0.720781 | 4 | 0 | 4 |
| IRAK3 | IGDCC4 | 0.719687 | 5 | 0 | 5 |
| IRAK3 | FBN1 | 0.717112 | 6 | 0 | 6 |
| IRAK3 | C7 | 0.715874 | 3 | 0 | 3 |
| IRAK3 | SLCO2A1 | 0.714004 | 3 | 0 | 3 |
| IRAK3 | TGFBR2 | 0.712495 | 5 | 0 | 4 |
| IRAK3 | HAUS6 | 0.712294 | 3 | 0 | 3 |
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