| Full name: tryptase alpha/beta 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 7177 | HGNC ID: HGNC:12019 | Ensembl Gene: ENSG00000172236 | OMIM ID: 191080 |
| Drug and gene relationship at DGIdb | |||
Expression of TPSAB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPSAB1 | 7177 | 205683_x_at | -1.3992 | 0.3522 | |
| GSE20347 | TPSAB1 | 7177 | 205683_x_at | -1.0229 | 0.0068 | |
| GSE23400 | TPSAB1 | 7177 | 205683_x_at | -0.8416 | 0.0000 | |
| GSE26886 | TPSAB1 | 7177 | 205683_x_at | -0.1597 | 0.6837 | |
| GSE29001 | TPSAB1 | 7177 | 205683_x_at | -0.4250 | 0.2928 | |
| GSE38129 | TPSAB1 | 7177 | 205683_x_at | -1.1579 | 0.0015 | |
| GSE45670 | TPSAB1 | 7177 | 216485_s_at | -0.1195 | 0.1967 | |
| GSE63941 | TPSAB1 | 7177 | 215382_x_at | 0.2839 | 0.0818 | |
| GSE77861 | TPSAB1 | 7177 | 205683_x_at | 0.3207 | 0.5730 | |
| GSE97050 | TPSAB1 | 7177 | A_23_P37702 | -0.4403 | 0.4357 | |
| SRP007169 | TPSAB1 | 7177 | RNAseq | -1.3220 | 0.0757 | |
| SRP008496 | TPSAB1 | 7177 | RNAseq | 0.2161 | 0.8054 | |
| SRP064894 | TPSAB1 | 7177 | RNAseq | -0.1822 | 0.7553 | |
| SRP133303 | TPSAB1 | 7177 | RNAseq | -1.6523 | 0.0005 | |
| SRP159526 | TPSAB1 | 7177 | RNAseq | -0.5385 | 0.5442 | |
| SRP193095 | TPSAB1 | 7177 | RNAseq | -0.1210 | 0.7575 | |
| SRP219564 | TPSAB1 | 7177 | RNAseq | 0.0637 | 0.9418 | |
| TCGA | TPSAB1 | 7177 | RNAseq | -0.5704 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TPSAB1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of TPSAB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPSAB1 | 7177 | 5 | 5 | 20 | |
| GSE20123 | TPSAB1 | 7177 | 5 | 4 | 21 | |
| GSE43470 | TPSAB1 | 7177 | 4 | 7 | 32 | |
| GSE46452 | TPSAB1 | 7177 | 38 | 1 | 20 | |
| GSE47630 | TPSAB1 | 7177 | 13 | 6 | 21 | |
| GSE54993 | TPSAB1 | 7177 | 3 | 5 | 62 | |
| GSE54994 | TPSAB1 | 7177 | 5 | 9 | 39 | |
| GSE60625 | TPSAB1 | 7177 | 4 | 0 | 7 | |
| GSE74703 | TPSAB1 | 7177 | 4 | 5 | 27 | |
| GSE74704 | TPSAB1 | 7177 | 3 | 2 | 15 | |
| TCGA | TPSAB1 | 7177 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of TPSAB1:
Generating mutation plots.
Highly correlated genes for TPSAB1:
Showing top 20/85 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPSAB1 | TPSB2 | 0.903138 | 9 | 0 | 8 |
| TPSAB1 | CPA3 | 0.78061 | 8 | 0 | 8 |
| TPSAB1 | TNFRSF17 | 0.661105 | 3 | 0 | 3 |
| TPSAB1 | TEK | 0.641652 | 4 | 0 | 4 |
| TPSAB1 | SLC18A2 | 0.635074 | 7 | 0 | 5 |
| TPSAB1 | MMRN1 | 0.620202 | 5 | 0 | 4 |
| TPSAB1 | EFCAB5 | 0.619 | 3 | 0 | 3 |
| TPSAB1 | MEOX1 | 0.611275 | 4 | 0 | 3 |
| TPSAB1 | PTPRT | 0.60507 | 3 | 0 | 3 |
| TPSAB1 | HDC | 0.603118 | 7 | 0 | 6 |
| TPSAB1 | PDE2A | 0.601279 | 6 | 0 | 5 |
| TPSAB1 | VWA5A | 0.599898 | 6 | 0 | 4 |
| TPSAB1 | CD79A | 0.599661 | 3 | 0 | 3 |
| TPSAB1 | VWF | 0.5936 | 6 | 0 | 4 |
| TPSAB1 | CTSG | 0.588935 | 7 | 0 | 5 |
| TPSAB1 | ELMO1 | 0.587378 | 4 | 0 | 3 |
| TPSAB1 | ACKR1 | 0.585898 | 8 | 0 | 6 |
| TPSAB1 | CHRDL1 | 0.583782 | 5 | 0 | 4 |
| TPSAB1 | LRRC43 | 0.580022 | 3 | 0 | 3 |
| TPSAB1 | SORBS2 | 0.579655 | 4 | 0 | 4 |
For details and further investigation, click here
