| Full name: tryptase beta 2 (gene/pseudogene) | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 64499 | HGNC ID: HGNC:14120 | Ensembl Gene: ENSG00000197253 | OMIM ID: 191081 |
| Drug and gene relationship at DGIdb | |||
Expression of TPSB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TPSB2 | 64499 | 207134_x_at | -1.3849 | 0.3565 | |
| GSE20347 | TPSB2 | 64499 | 207134_x_at | -1.0643 | 0.0035 | |
| GSE23400 | TPSB2 | 64499 | 207134_x_at | -0.8957 | 0.0000 | |
| GSE26886 | TPSB2 | 64499 | 207134_x_at | -0.0476 | 0.9139 | |
| GSE29001 | TPSB2 | 64499 | 207134_x_at | -0.3683 | 0.2783 | |
| GSE38129 | TPSB2 | 64499 | 207134_x_at | -1.1503 | 0.0008 | |
| GSE45670 | TPSB2 | 64499 | 207134_x_at | -0.4030 | 0.0526 | |
| GSE53622 | TPSB2 | 64499 | 35537 | -0.3271 | 0.0077 | |
| GSE53624 | TPSB2 | 64499 | 35537 | -1.6309 | 0.0000 | |
| GSE63941 | TPSB2 | 64499 | 207134_x_at | -0.0566 | 0.7319 | |
| GSE77861 | TPSB2 | 64499 | 207134_x_at | 0.3432 | 0.5519 | |
| SRP007169 | TPSB2 | 64499 | RNAseq | -0.9387 | 0.1274 | |
| SRP008496 | TPSB2 | 64499 | RNAseq | 0.4189 | 0.6047 | |
| SRP064894 | TPSB2 | 64499 | RNAseq | -1.1908 | 0.0138 | |
| SRP133303 | TPSB2 | 64499 | RNAseq | -1.5232 | 0.0044 | |
| SRP159526 | TPSB2 | 64499 | RNAseq | -0.4879 | 0.5474 | |
| SRP193095 | TPSB2 | 64499 | RNAseq | 0.0093 | 0.9783 | |
| SRP219564 | TPSB2 | 64499 | RNAseq | -0.4033 | 0.6362 | |
| TCGA | TPSB2 | 64499 | RNAseq | -0.7041 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by TPSB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TPSB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TPSB2 | 64499 | 5 | 5 | 20 | |
| GSE20123 | TPSB2 | 64499 | 5 | 4 | 21 | |
| GSE43470 | TPSB2 | 64499 | 4 | 7 | 32 | |
| GSE46452 | TPSB2 | 64499 | 38 | 1 | 20 | |
| GSE47630 | TPSB2 | 64499 | 13 | 6 | 21 | |
| GSE54993 | TPSB2 | 64499 | 3 | 5 | 62 | |
| GSE54994 | TPSB2 | 64499 | 5 | 9 | 39 | |
| GSE60625 | TPSB2 | 64499 | 4 | 0 | 7 | |
| GSE74703 | TPSB2 | 64499 | 4 | 5 | 27 | |
| GSE74704 | TPSB2 | 64499 | 3 | 2 | 15 | |
| TCGA | TPSB2 | 64499 | 19 | 14 | 63 |
Total number of gains: 103; Total number of losses: 58; Total Number of normals: 327.
Somatic mutations of TPSB2:
Generating mutation plots.
Highly correlated genes for TPSB2:
Showing top 20/181 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TPSB2 | TPSAB1 | 0.903138 | 9 | 0 | 8 |
| TPSB2 | CPA3 | 0.781886 | 9 | 0 | 9 |
| TPSB2 | ZNF521 | 0.711752 | 3 | 0 | 3 |
| TPSB2 | SLC18A2 | 0.668238 | 8 | 0 | 6 |
| TPSB2 | TFPI | 0.648902 | 5 | 0 | 5 |
| TPSB2 | SOX5 | 0.634455 | 3 | 0 | 3 |
| TPSB2 | DOCK10 | 0.63255 | 3 | 0 | 3 |
| TPSB2 | LYVE1 | 0.625821 | 6 | 0 | 5 |
| TPSB2 | LINC01279 | 0.62546 | 3 | 0 | 3 |
| TPSB2 | CTSG | 0.621501 | 8 | 0 | 6 |
| TPSB2 | TEK | 0.621154 | 5 | 0 | 5 |
| TPSB2 | CNRIP1 | 0.618867 | 5 | 0 | 4 |
| TPSB2 | PTGDS | 0.604615 | 9 | 0 | 7 |
| TPSB2 | ACKR1 | 0.599736 | 9 | 0 | 7 |
| TPSB2 | TGM3 | 0.598044 | 4 | 0 | 3 |
| TPSB2 | HDC | 0.596047 | 9 | 0 | 7 |
| TPSB2 | SCARA5 | 0.594993 | 4 | 0 | 3 |
| TPSB2 | HPGDS | 0.594271 | 7 | 0 | 3 |
| TPSB2 | MS4A2 | 0.593209 | 8 | 0 | 4 |
| TPSB2 | PLCXD3 | 0.593015 | 3 | 0 | 3 |
For details and further investigation, click here
