| Full name: coproporphyrinogen oxidase | Alias Symbol: CPX|HCP | ||
| Type: protein-coding gene | Cytoband: 3q11.2 | ||
| Entrez ID: 1371 | HGNC ID: HGNC:2321 | Ensembl Gene: ENSG00000080819 | OMIM ID: 612732 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CPOX:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPOX | 1371 | 204172_at | 0.2895 | 0.7041 | |
| GSE20347 | CPOX | 1371 | 204172_at | 0.4252 | 0.0221 | |
| GSE23400 | CPOX | 1371 | 204172_at | 0.1623 | 0.0463 | |
| GSE26886 | CPOX | 1371 | 204172_at | -0.0710 | 0.8015 | |
| GSE29001 | CPOX | 1371 | 204172_at | -0.0408 | 0.9501 | |
| GSE38129 | CPOX | 1371 | 204172_at | 0.6218 | 0.0008 | |
| GSE45670 | CPOX | 1371 | 204172_at | 0.5276 | 0.0056 | |
| GSE53622 | CPOX | 1371 | 55857 | 0.2089 | 0.0454 | |
| GSE53624 | CPOX | 1371 | 55857 | 0.2836 | 0.0000 | |
| GSE63941 | CPOX | 1371 | 204172_at | -0.0147 | 0.9847 | |
| GSE77861 | CPOX | 1371 | 204172_at | -0.1355 | 0.7303 | |
| GSE97050 | CPOX | 1371 | A_33_P3301025 | 0.4610 | 0.2487 | |
| SRP007169 | CPOX | 1371 | RNAseq | 0.3170 | 0.5691 | |
| SRP008496 | CPOX | 1371 | RNAseq | -0.0375 | 0.9091 | |
| SRP064894 | CPOX | 1371 | RNAseq | 0.0781 | 0.6814 | |
| SRP133303 | CPOX | 1371 | RNAseq | 0.2619 | 0.2690 | |
| SRP159526 | CPOX | 1371 | RNAseq | 0.2442 | 0.4210 | |
| SRP193095 | CPOX | 1371 | RNAseq | 0.1491 | 0.3014 | |
| SRP219564 | CPOX | 1371 | RNAseq | -0.0310 | 0.9423 | |
| TCGA | CPOX | 1371 | RNAseq | 0.3044 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CPOX expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPOX:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPOX | 1371 | 20 | 1 | 9 | |
| GSE20123 | CPOX | 1371 | 19 | 1 | 10 | |
| GSE43470 | CPOX | 1371 | 18 | 1 | 24 | |
| GSE46452 | CPOX | 1371 | 12 | 6 | 41 | |
| GSE47630 | CPOX | 1371 | 16 | 6 | 18 | |
| GSE54993 | CPOX | 1371 | 2 | 5 | 63 | |
| GSE54994 | CPOX | 1371 | 27 | 5 | 21 | |
| GSE60625 | CPOX | 1371 | 0 | 6 | 5 | |
| GSE74703 | CPOX | 1371 | 14 | 1 | 21 | |
| GSE74704 | CPOX | 1371 | 14 | 1 | 5 | |
| TCGA | CPOX | 1371 | 50 | 10 | 36 |
Total number of gains: 192; Total number of losses: 43; Total Number of normals: 253.
Somatic mutations of CPOX:
Generating mutation plots.
Highly correlated genes for CPOX:
Showing top 20/335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPOX | EZR | 0.741776 | 3 | 0 | 3 |
| CPOX | ASL | 0.704414 | 3 | 0 | 3 |
| CPOX | MGAT4B | 0.691425 | 3 | 0 | 3 |
| CPOX | GLMN | 0.670987 | 4 | 0 | 4 |
| CPOX | SCFD1 | 0.658286 | 4 | 0 | 3 |
| CPOX | ZNF165 | 0.653614 | 4 | 0 | 4 |
| CPOX | TRAF7 | 0.647878 | 3 | 0 | 3 |
| CPOX | ASCC3 | 0.647338 | 4 | 0 | 3 |
| CPOX | SLC30A5 | 0.645434 | 4 | 0 | 3 |
| CPOX | GOLGA5 | 0.645383 | 4 | 0 | 3 |
| CPOX | CALML5 | 0.643026 | 3 | 0 | 3 |
| CPOX | TOR1B | 0.641603 | 3 | 0 | 3 |
| CPOX | COX16 | 0.641431 | 3 | 0 | 3 |
| CPOX | MREG | 0.639778 | 5 | 0 | 4 |
| CPOX | PSMA5 | 0.636184 | 4 | 0 | 3 |
| CPOX | ATP2C2 | 0.635187 | 4 | 0 | 3 |
| CPOX | PTGR2 | 0.628777 | 3 | 0 | 3 |
| CPOX | CHEK1 | 0.628246 | 5 | 0 | 4 |
| CPOX | CLPX | 0.623881 | 4 | 0 | 3 |
| CPOX | HUS1 | 0.622682 | 4 | 0 | 4 |
For details and further investigation, click here
