CHEK1

 

Full name: checkpoint kinase 1 Alias Symbol: CHK1
Type: protein-coding gene Cytoband: 11q24.2
Entrez ID: 1111 HGNC ID: HGNC:1925 Ensembl Gene: ENSG00000149554 OMIM ID: 603078
Drug and gene relationship at DGIdb

 

CHEK1 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa05166HTLV-I infection

 

Expression of CHEK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHEK1 1111 205394_at 1.3877 0.0286
GSE20347 CHEK1 1111 205394_at 1.2126 0.0000
GSE23400 CHEK1 1111 205394_at 0.6936 0.0000
GSE26886 CHEK1 1111 205394_at 0.8404 0.0205
GSE29001 CHEK1 1111 205394_at 1.5644 0.0013
GSE38129 CHEK1 1111 205394_at 1.4181 0.0000
GSE45670 CHEK1 1111 238075_at 1.2451 0.0000
GSE53622 CHEK1 1111 38020 1.3384 0.0000
GSE53624 CHEK1 1111 38020 1.5845 0.0000
GSE63941 CHEK1 1111 205394_at 1.6738 0.0028
GSE77861 CHEK1 1111 205393_s_at 0.6880 0.0950
GSE97050 CHEK1 1111 A_33_P3349536 1.4374 0.1555
SRP007169 CHEK1 1111 RNAseq 1.5126 0.0009
SRP008496 CHEK1 1111 RNAseq 1.7770 0.0000
SRP064894 CHEK1 1111 RNAseq 1.0213 0.0000
SRP133303 CHEK1 1111 RNAseq 0.9699 0.0000
SRP159526 CHEK1 1111 RNAseq 0.7945 0.0112
SRP193095 CHEK1 1111 RNAseq 0.5205 0.0003
SRP219564 CHEK1 1111 RNAseq 0.8456 0.0458
TCGA CHEK1 1111 RNAseq 0.8594 0.0000

Upregulated datasets: 11; Downregulated datasets: 0.  

 

Survival by CHEK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHEK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHEK1 1111 0 13 17
GSE20123 CHEK1 1111 0 13 17
GSE43470 CHEK1 1111 2 7 34
GSE46452 CHEK1 1111 3 26 30
GSE47630 CHEK1 1111 2 19 19
GSE54993 CHEK1 1111 10 0 60
GSE54994 CHEK1 1111 5 19 29
GSE60625 CHEK1 1111 0 3 8
GSE74703 CHEK1 1111 1 5 30
GSE74704 CHEK1 1111 0 9 11
TCGA CHEK1 1111 7 50 39

Total number of gains: 30; Total number of losses: 164; Total Number of normals: 294.  

 

Somatic mutations of CHEK1:

 

Generating mutation plots.

 

Highly correlated genes for CHEK1:

 

Showing top 20/1691 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHEK1CDK10.80490712012
CHEK1DDIAS0.799437707
CHEK1TTK0.79935712012
CHEK1CDCA50.798104707
CHEK1RAD51AP10.79645113013
CHEK1GMNN0.79505813013
CHEK1DLGAP50.79466913013
CHEK1KIF230.79460213013
CHEK1FEN10.79439909
CHEK1FOXM10.79401612012
CHEK1CDC200.79390411010
CHEK1CDKN30.78950413013
CHEK1ATAD20.78908513013
CHEK1CDCA20.786618707
CHEK1BUB10.7856511011
CHEK1MELK0.78558113013
CHEK1KIF2C0.78366512012
CHEK1HMMR0.78361212011
CHEK1TPX20.78289813011
CHEK1CEP550.78282913013

For details and further investigation, click here