| Full name: activating signal cointegrator 1 complex subunit 3 | Alias Symbol: RNAH|ASC1p200|dJ121G13.4|dJ467N11.1 | ||
| Type: protein-coding gene | Cytoband: 6q16.3 | ||
| Entrez ID: 10973 | HGNC ID: HGNC:18697 | Ensembl Gene: ENSG00000112249 | OMIM ID: 614217 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of ASCC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASCC3 | 10973 | 212815_at | 0.1497 | 0.8724 | |
| GSE20347 | ASCC3 | 10973 | 212815_at | -0.1361 | 0.5556 | |
| GSE23400 | ASCC3 | 10973 | 212815_at | 0.4073 | 0.0000 | |
| GSE26886 | ASCC3 | 10973 | 212815_at | 0.3051 | 0.2504 | |
| GSE29001 | ASCC3 | 10973 | 212815_at | 0.1094 | 0.8296 | |
| GSE38129 | ASCC3 | 10973 | 212815_at | 0.1378 | 0.4539 | |
| GSE45670 | ASCC3 | 10973 | 212815_at | 0.3320 | 0.0125 | |
| GSE53622 | ASCC3 | 10973 | 4889 | 0.3009 | 0.0000 | |
| GSE53624 | ASCC3 | 10973 | 4889 | 0.4453 | 0.0000 | |
| GSE63941 | ASCC3 | 10973 | 212815_at | -0.7733 | 0.1383 | |
| GSE77861 | ASCC3 | 10973 | 212815_at | -0.0812 | 0.8376 | |
| GSE97050 | ASCC3 | 10973 | A_23_P30972 | 0.5047 | 0.2471 | |
| SRP007169 | ASCC3 | 10973 | RNAseq | 0.2079 | 0.5137 | |
| SRP008496 | ASCC3 | 10973 | RNAseq | 0.1775 | 0.3210 | |
| SRP064894 | ASCC3 | 10973 | RNAseq | 0.1946 | 0.4511 | |
| SRP133303 | ASCC3 | 10973 | RNAseq | 0.3830 | 0.0164 | |
| SRP159526 | ASCC3 | 10973 | RNAseq | -0.0236 | 0.9378 | |
| SRP193095 | ASCC3 | 10973 | RNAseq | 0.0492 | 0.5221 | |
| SRP219564 | ASCC3 | 10973 | RNAseq | 0.2648 | 0.5270 | |
| TCGA | ASCC3 | 10973 | RNAseq | 0.1529 | 0.0030 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASCC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASCC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASCC3 | 10973 | 1 | 3 | 26 | |
| GSE20123 | ASCC3 | 10973 | 1 | 2 | 27 | |
| GSE43470 | ASCC3 | 10973 | 3 | 0 | 40 | |
| GSE46452 | ASCC3 | 10973 | 2 | 11 | 46 | |
| GSE47630 | ASCC3 | 10973 | 8 | 6 | 26 | |
| GSE54993 | ASCC3 | 10973 | 3 | 2 | 65 | |
| GSE54994 | ASCC3 | 10973 | 8 | 8 | 37 | |
| GSE60625 | ASCC3 | 10973 | 0 | 1 | 10 | |
| GSE74703 | ASCC3 | 10973 | 2 | 0 | 34 | |
| GSE74704 | ASCC3 | 10973 | 0 | 0 | 20 | |
| TCGA | ASCC3 | 10973 | 7 | 28 | 61 |
Total number of gains: 35; Total number of losses: 61; Total Number of normals: 392.
Somatic mutations of ASCC3:
Generating mutation plots.
Highly correlated genes for ASCC3:
Showing top 20/616 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASCC3 | FKTN | 0.778301 | 3 | 0 | 3 |
| ASCC3 | XBP1 | 0.776105 | 3 | 0 | 3 |
| ASCC3 | SPAG1 | 0.767844 | 3 | 0 | 3 |
| ASCC3 | EIF2AK4 | 0.761758 | 3 | 0 | 3 |
| ASCC3 | MTX3 | 0.754506 | 3 | 0 | 3 |
| ASCC3 | HSPA4L | 0.75122 | 5 | 0 | 5 |
| ASCC3 | DCTN6 | 0.749782 | 3 | 0 | 3 |
| ASCC3 | LYSMD2 | 0.741979 | 3 | 0 | 3 |
| ASCC3 | TTI2 | 0.738656 | 3 | 0 | 3 |
| ASCC3 | CASP3 | 0.7375 | 3 | 0 | 3 |
| ASCC3 | CPVL | 0.736047 | 4 | 0 | 3 |
| ASCC3 | POLI | 0.735441 | 3 | 0 | 3 |
| ASCC3 | MRPL46 | 0.735243 | 4 | 0 | 4 |
| ASCC3 | RAD17 | 0.735114 | 4 | 0 | 4 |
| ASCC3 | FRK | 0.734758 | 3 | 0 | 3 |
| ASCC3 | STX18 | 0.732126 | 3 | 0 | 3 |
| ASCC3 | LRIG3 | 0.727888 | 3 | 0 | 3 |
| ASCC3 | TTC39C | 0.723209 | 3 | 0 | 3 |
| ASCC3 | WDR20 | 0.717045 | 3 | 0 | 3 |
| ASCC3 | IFT52 | 0.716827 | 3 | 0 | 3 |
For details and further investigation, click here
