CALML5

 

Full name: calmodulin like 5 Alias Symbol: CLSP
Type: protein-coding gene Cytoband: 10p15.1
Entrez ID: 51806 HGNC ID: HGNC:18180 Ensembl Gene: ENSG00000178372 OMIM ID: 605183
Drug and gene relationship at DGIdb

 

CALML5 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04728Dopaminergic synapse
hsa04740Olfactory transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa05010Alzheimer's disease
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05152Tuberculosis
hsa05214Glioma

 

Expression of CALML5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CALML5 51806 220414_at 0.8908 0.5180
GSE20347 CALML5 51806 220414_at -1.0973 0.0150
GSE23400 CALML5 51806 220414_at -0.1490 0.4779
GSE26886 CALML5 51806 220414_at -0.2760 0.7147
GSE29001 CALML5 51806 220414_at 0.8875 0.2289
GSE38129 CALML5 51806 220414_at -0.2472 0.6890
GSE45670 CALML5 51806 220414_at 0.6695 0.2870
GSE53622 CALML5 51806 29352 0.3196 0.3330
GSE53624 CALML5 51806 29352 -0.1920 0.4289
GSE63941 CALML5 51806 220414_at 0.3676 0.7710
GSE77861 CALML5 51806 220414_at -0.2541 0.8255
GSE97050 CALML5 51806 A_33_P3339865 1.2306 0.1504
SRP007169 CALML5 51806 RNAseq -0.5315 0.7180
SRP008496 CALML5 51806 RNAseq -0.2871 0.8324
SRP064894 CALML5 51806 RNAseq 1.8149 0.0017
SRP133303 CALML5 51806 RNAseq 1.4363 0.0804
SRP159526 CALML5 51806 RNAseq -1.0275 0.2333
SRP219564 CALML5 51806 RNAseq -2.9355 0.0352
TCGA CALML5 51806 RNAseq 1.3054 0.0026

Upregulated datasets: 2; Downregulated datasets: 2.  

 

Survival by CALML5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CALML5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CALML5 51806 6 7 17
GSE20123 CALML5 51806 6 6 18
GSE43470 CALML5 51806 4 6 33
GSE46452 CALML5 51806 2 14 43
GSE47630 CALML5 51806 6 14 20
GSE54993 CALML5 51806 11 0 59
GSE54994 CALML5 51806 5 10 38
GSE60625 CALML5 51806 0 0 11
GSE74703 CALML5 51806 3 4 29
GSE74704 CALML5 51806 1 5 14
TCGA CALML5 51806 21 24 51

Total number of gains: 65; Total number of losses: 90; Total Number of normals: 333.  

 

Somatic mutations of CALML5:

 

Generating mutation plots.

 

Highly correlated genes for CALML5:

 

Showing top 20/83 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CALML5ATG30.782519303
CALML5MFSD30.728917303
CALML5DTX40.72595303
CALML5CD960.725402303
CALML5PLAG10.725036303
CALML5POLR2B0.722838303
CALML5ZAP700.718672303
CALML5ERGIC30.716686303
CALML5C16orf540.715506303
CALML5LCK0.714887303
CALML5GAR10.713437303
CALML5ALG10.713179303
CALML5GSK3B0.712428303
CALML5MED190.705211303
CALML5SRPRB0.703124303
CALML5NAA500.702311403
CALML5HLA-DPA10.687113303
CALML5C2orf680.684838303
CALML5ABHD16A0.684687303
CALML5FGF110.683584303

For details and further investigation, click here