| Full name: complement C3d receptor 2 | Alias Symbol: CD21|C3DR | ||
| Type: protein-coding gene | Cytoband: 1q32.2 | ||
| Entrez ID: 1380 | HGNC ID: HGNC:2336 | Ensembl Gene: ENSG00000117322 | OMIM ID: 120650 |
| Drug and gene relationship at DGIdb | |||
CR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05169 | Epstein-Barr virus infection |
Expression of CR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CR2 | 1380 | 205544_s_at | -0.1887 | 0.9297 | |
| GSE20347 | CR2 | 1380 | 205544_s_at | 0.1494 | 0.6038 | |
| GSE23400 | CR2 | 1380 | 205544_s_at | -0.2230 | 0.0207 | |
| GSE26886 | CR2 | 1380 | 205544_s_at | -0.0311 | 0.8536 | |
| GSE29001 | CR2 | 1380 | 205544_s_at | 0.1269 | 0.6845 | |
| GSE38129 | CR2 | 1380 | 205544_s_at | -0.1267 | 0.7366 | |
| GSE45670 | CR2 | 1380 | 205544_s_at | -0.2325 | 0.7506 | |
| GSE53622 | CR2 | 1380 | 32890 | -0.9473 | 0.0000 | |
| GSE53624 | CR2 | 1380 | 32890 | -2.0507 | 0.0000 | |
| GSE63941 | CR2 | 1380 | 205544_s_at | 0.5832 | 0.2542 | |
| GSE77861 | CR2 | 1380 | 205544_s_at | 0.0246 | 0.8847 | |
| GSE97050 | CR2 | 1380 | A_33_P3281985 | 0.9307 | 0.2332 | |
| SRP133303 | CR2 | 1380 | RNAseq | -1.5796 | 0.0947 | |
| SRP159526 | CR2 | 1380 | RNAseq | -2.7982 | 0.0125 | |
| TCGA | CR2 | 1380 | RNAseq | -0.8102 | 0.2884 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CR2 | 1380 | 11 | 0 | 19 | |
| GSE20123 | CR2 | 1380 | 11 | 0 | 19 | |
| GSE43470 | CR2 | 1380 | 8 | 0 | 35 | |
| GSE46452 | CR2 | 1380 | 3 | 1 | 55 | |
| GSE47630 | CR2 | 1380 | 14 | 0 | 26 | |
| GSE54993 | CR2 | 1380 | 0 | 6 | 64 | |
| GSE54994 | CR2 | 1380 | 14 | 0 | 39 | |
| GSE60625 | CR2 | 1380 | 0 | 0 | 11 | |
| GSE74703 | CR2 | 1380 | 8 | 0 | 28 | |
| GSE74704 | CR2 | 1380 | 5 | 0 | 15 | |
| TCGA | CR2 | 1380 | 45 | 3 | 48 |
Total number of gains: 119; Total number of losses: 10; Total Number of normals: 359.
Somatic mutations of CR2:
Generating mutation plots.
Highly correlated genes for CR2:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CR2 | MS4A1 | 0.792342 | 10 | 0 | 10 |
| CR2 | LINC01215 | 0.759441 | 5 | 0 | 5 |
| CR2 | CD19 | 0.734748 | 11 | 0 | 10 |
| CR2 | VPREB3 | 0.734439 | 9 | 0 | 9 |
| CR2 | CD79B | 0.708642 | 8 | 0 | 8 |
| CR2 | FCAMR | 0.695313 | 5 | 0 | 4 |
| CR2 | TLR10 | 0.694036 | 5 | 0 | 4 |
| CR2 | SLC15A1 | 0.673234 | 3 | 0 | 3 |
| CR2 | GAPT | 0.669412 | 4 | 0 | 4 |
| CR2 | CD37 | 0.663919 | 9 | 0 | 7 |
| CR2 | CYB5R4 | 0.662173 | 3 | 0 | 3 |
| CR2 | PAX5 | 0.657755 | 9 | 0 | 7 |
| CR2 | BLK | 0.650521 | 6 | 0 | 5 |
| CR2 | CD22 | 0.648119 | 11 | 0 | 9 |
| CR2 | CD79A | 0.645934 | 12 | 0 | 9 |
| CR2 | PVRIG | 0.638065 | 7 | 0 | 5 |
| CR2 | NAPSA | 0.633093 | 4 | 0 | 3 |
| CR2 | SPIB | 0.630851 | 8 | 0 | 6 |
| CR2 | IGLL1 | 0.630322 | 4 | 0 | 3 |
| CR2 | TLR6 | 0.619329 | 3 | 0 | 3 |
For details and further investigation, click here
