| Full name: toll like receptor 6 | Alias Symbol: CD286 | ||
| Type: protein-coding gene | Cytoband: 4p14 | ||
| Entrez ID: 10333 | HGNC ID: HGNC:16711 | Ensembl Gene: ENSG00000174130 | OMIM ID: 605403 |
| Drug and gene relationship at DGIdb | |||
TLR6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04620 | Toll-like receptor signaling pathway | |
| hsa05142 | Chagas disease (American trypanosomiasis) | |
| hsa05152 | Tuberculosis |
Expression of TLR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLR6 | 10333 | 239021_at | 0.3068 | 0.3386 | |
| GSE20347 | TLR6 | 10333 | 207446_at | 0.0898 | 0.0579 | |
| GSE23400 | TLR6 | 10333 | 207446_at | -0.0264 | 0.4100 | |
| GSE26886 | TLR6 | 10333 | 239021_at | 0.3579 | 0.0069 | |
| GSE29001 | TLR6 | 10333 | 207446_at | -0.1285 | 0.4871 | |
| GSE38129 | TLR6 | 10333 | 207446_at | 0.0010 | 0.9890 | |
| GSE45670 | TLR6 | 10333 | 239021_at | 0.2576 | 0.0169 | |
| GSE53622 | TLR6 | 10333 | 51560 | 0.3574 | 0.0011 | |
| GSE53624 | TLR6 | 10333 | 51560 | 0.3953 | 0.0000 | |
| GSE63941 | TLR6 | 10333 | 207446_at | 0.4748 | 0.3613 | |
| GSE77861 | TLR6 | 10333 | 239021_at | -0.1418 | 0.3246 | |
| GSE97050 | TLR6 | 10333 | A_23_P256561 | 0.4565 | 0.3115 | |
| SRP007169 | TLR6 | 10333 | RNAseq | 1.3131 | 0.0540 | |
| SRP064894 | TLR6 | 10333 | RNAseq | 0.8015 | 0.0038 | |
| SRP133303 | TLR6 | 10333 | RNAseq | 0.2796 | 0.3040 | |
| SRP159526 | TLR6 | 10333 | RNAseq | 0.2793 | 0.6051 | |
| SRP193095 | TLR6 | 10333 | RNAseq | 1.0529 | 0.0000 | |
| SRP219564 | TLR6 | 10333 | RNAseq | 0.7840 | 0.1551 | |
| TCGA | TLR6 | 10333 | RNAseq | 1.0221 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TLR6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLR6 | 10333 | 0 | 16 | 14 | |
| GSE20123 | TLR6 | 10333 | 0 | 16 | 14 | |
| GSE43470 | TLR6 | 10333 | 0 | 15 | 28 | |
| GSE46452 | TLR6 | 10333 | 1 | 36 | 22 | |
| GSE47630 | TLR6 | 10333 | 1 | 19 | 20 | |
| GSE54993 | TLR6 | 10333 | 8 | 0 | 62 | |
| GSE54994 | TLR6 | 10333 | 4 | 10 | 39 | |
| GSE60625 | TLR6 | 10333 | 0 | 0 | 11 | |
| GSE74703 | TLR6 | 10333 | 0 | 12 | 24 | |
| GSE74704 | TLR6 | 10333 | 0 | 9 | 11 | |
| TCGA | TLR6 | 10333 | 11 | 45 | 40 |
Total number of gains: 25; Total number of losses: 178; Total Number of normals: 285.
Somatic mutations of TLR6:
Generating mutation plots.
Highly correlated genes for TLR6:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLR6 | GMIP | 0.793825 | 3 | 0 | 3 |
| TLR6 | LIMD1 | 0.711961 | 3 | 0 | 3 |
| TLR6 | CDHR2 | 0.701542 | 3 | 0 | 3 |
| TLR6 | ZNF620 | 0.673401 | 3 | 0 | 3 |
| TLR6 | ST3GAL1 | 0.66791 | 3 | 0 | 3 |
| TLR6 | GNB3 | 0.66706 | 5 | 0 | 4 |
| TLR6 | TRIM31 | 0.664906 | 3 | 0 | 3 |
| TLR6 | CELF4 | 0.66426 | 3 | 0 | 3 |
| TLR6 | FAM78A | 0.662691 | 3 | 0 | 3 |
| TLR6 | TYMP | 0.660663 | 3 | 0 | 3 |
| TLR6 | LRRN4 | 0.659002 | 3 | 0 | 3 |
| TLR6 | SHANK1 | 0.64697 | 4 | 0 | 3 |
| TLR6 | ZNF341 | 0.645971 | 3 | 0 | 3 |
| TLR6 | SCN1B | 0.645088 | 3 | 0 | 3 |
| TLR6 | GPR52 | 0.644544 | 6 | 0 | 5 |
| TLR6 | SMOC1 | 0.643605 | 3 | 0 | 3 |
| TLR6 | TLX2 | 0.641258 | 4 | 0 | 4 |
| TLR6 | LRRC45 | 0.640341 | 4 | 0 | 3 |
| TLR6 | MEPE | 0.634894 | 5 | 0 | 4 |
| TLR6 | FMNL1 | 0.63468 | 5 | 0 | 3 |
For details and further investigation, click here
