| Full name: CD22 molecule | Alias Symbol: SIGLEC-2|SIGLEC2 | ||
| Type: protein-coding gene | Cytoband: 19q13.12 | ||
| Entrez ID: 933 | HGNC ID: HGNC:1643 | Ensembl Gene: ENSG00000012124 | OMIM ID: 107266 |
| Drug and gene relationship at DGIdb | |||
CD22 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04662 | B cell receptor signaling pathway |
Expression of CD22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD22 | 933 | 38521_at | 0.0960 | 0.8373 | |
| GSE20347 | CD22 | 933 | 38521_at | 0.1767 | 0.0811 | |
| GSE23400 | CD22 | 933 | 38521_at | -0.0001 | 0.9966 | |
| GSE26886 | CD22 | 933 | 38521_at | 0.0171 | 0.9025 | |
| GSE29001 | CD22 | 933 | 38521_at | -0.1364 | 0.4777 | |
| GSE38129 | CD22 | 933 | 38521_at | -0.0771 | 0.5894 | |
| GSE45670 | CD22 | 933 | 38521_at | -0.0453 | 0.6678 | |
| GSE53622 | CD22 | 933 | 85736 | -1.0060 | 0.0000 | |
| GSE53624 | CD22 | 933 | 85736 | -1.2457 | 0.0000 | |
| GSE63941 | CD22 | 933 | 38521_at | 0.4341 | 0.0019 | |
| GSE77861 | CD22 | 933 | 38521_at | 0.0720 | 0.4993 | |
| GSE97050 | CD22 | 933 | A_23_P209055 | 1.1932 | 0.2368 | |
| SRP064894 | CD22 | 933 | RNAseq | -0.0626 | 0.8626 | |
| SRP133303 | CD22 | 933 | RNAseq | -0.9209 | 0.0124 | |
| SRP159526 | CD22 | 933 | RNAseq | -2.1068 | 0.0445 | |
| SRP193095 | CD22 | 933 | RNAseq | -0.0362 | 0.9127 | |
| SRP219564 | CD22 | 933 | RNAseq | 1.1265 | 0.0571 | |
| TCGA | CD22 | 933 | RNAseq | -0.6016 | 0.0954 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CD22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD22 | 933 | 6 | 4 | 20 | |
| GSE20123 | CD22 | 933 | 6 | 3 | 21 | |
| GSE43470 | CD22 | 933 | 3 | 7 | 33 | |
| GSE46452 | CD22 | 933 | 48 | 1 | 10 | |
| GSE47630 | CD22 | 933 | 9 | 5 | 26 | |
| GSE54993 | CD22 | 933 | 17 | 3 | 50 | |
| GSE54994 | CD22 | 933 | 8 | 9 | 36 | |
| GSE60625 | CD22 | 933 | 9 | 0 | 2 | |
| GSE74703 | CD22 | 933 | 3 | 4 | 29 | |
| GSE74704 | CD22 | 933 | 6 | 1 | 13 | |
| TCGA | CD22 | 933 | 21 | 11 | 64 |
Total number of gains: 136; Total number of losses: 48; Total Number of normals: 304.
Somatic mutations of CD22:
Generating mutation plots.
Highly correlated genes for CD22:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD22 | TNK1 | 0.824231 | 3 | 0 | 3 |
| CD22 | PPP1CA | 0.823722 | 3 | 0 | 3 |
| CD22 | CNKSR1 | 0.807518 | 3 | 0 | 3 |
| CD22 | DLL4 | 0.786464 | 3 | 0 | 3 |
| CD22 | PLEKHH1 | 0.769191 | 3 | 0 | 3 |
| CD22 | KRI1 | 0.768365 | 3 | 0 | 3 |
| CD22 | APOBEC3C | 0.76746 | 3 | 0 | 3 |
| CD22 | NUP210 | 0.759023 | 3 | 0 | 3 |
| CD22 | TRABD | 0.758206 | 3 | 0 | 3 |
| CD22 | LSM4 | 0.753001 | 3 | 0 | 3 |
| CD22 | FCRL3 | 0.742509 | 6 | 0 | 6 |
| CD22 | ZNF467 | 0.741539 | 3 | 0 | 3 |
| CD22 | FLOT2 | 0.741054 | 3 | 0 | 3 |
| CD22 | CIDEC | 0.73929 | 3 | 0 | 3 |
| CD22 | CD79B | 0.738473 | 8 | 0 | 7 |
| CD22 | VPS52 | 0.737926 | 3 | 0 | 3 |
| CD22 | ARHGAP15 | 0.737304 | 3 | 0 | 3 |
| CD22 | HHLA3 | 0.736252 | 3 | 0 | 3 |
| CD22 | PLEKHG3 | 0.733309 | 3 | 0 | 3 |
| CD22 | PTPRU | 0.72016 | 5 | 0 | 5 |
For details and further investigation, click here
