| Full name: CD19 molecule | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 930 | HGNC ID: HGNC:1633 | Ensembl Gene: ENSG00000177455 | OMIM ID: 107265 |
| Drug and gene relationship at DGIdb | |||
CD19 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04662 | B cell receptor signaling pathway | |
| hsa05169 | Epstein-Barr virus infection |
Expression of CD19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CD19 | 930 | 206398_s_at | 0.3750 | 0.7773 | |
| GSE20347 | CD19 | 930 | 206398_s_at | -0.1032 | 0.5665 | |
| GSE23400 | CD19 | 930 | 206398_s_at | -0.2919 | 0.0001 | |
| GSE26886 | CD19 | 930 | 206398_s_at | 0.0342 | 0.8442 | |
| GSE29001 | CD19 | 930 | 206398_s_at | -0.2034 | 0.2674 | |
| GSE38129 | CD19 | 930 | 206398_s_at | -0.2891 | 0.2501 | |
| GSE45670 | CD19 | 930 | 206398_s_at | -0.1427 | 0.5766 | |
| GSE53622 | CD19 | 930 | 6306 | -0.1737 | 0.4717 | |
| GSE53624 | CD19 | 930 | 6306 | -0.3893 | 0.0568 | |
| GSE63941 | CD19 | 930 | 206398_s_at | 0.2083 | 0.2515 | |
| GSE77861 | CD19 | 930 | 206398_s_at | -0.0040 | 0.9845 | |
| GSE97050 | CD19 | 930 | A_23_P113572 | 0.6759 | 0.2156 | |
| SRP133303 | CD19 | 930 | RNAseq | -0.5677 | 0.3374 | |
| SRP159526 | CD19 | 930 | RNAseq | -1.8475 | 0.1004 | |
| SRP219564 | CD19 | 930 | RNAseq | 0.4464 | 0.4644 | |
| TCGA | CD19 | 930 | RNAseq | -0.5698 | 0.3980 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CD19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CD19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CD19 | 930 | 5 | 5 | 20 | |
| GSE20123 | CD19 | 930 | 5 | 4 | 21 | |
| GSE43470 | CD19 | 930 | 3 | 3 | 37 | |
| GSE46452 | CD19 | 930 | 38 | 1 | 20 | |
| GSE47630 | CD19 | 930 | 11 | 7 | 22 | |
| GSE54993 | CD19 | 930 | 3 | 5 | 62 | |
| GSE54994 | CD19 | 930 | 5 | 9 | 39 | |
| GSE60625 | CD19 | 930 | 4 | 0 | 7 | |
| GSE74703 | CD19 | 930 | 3 | 2 | 31 | |
| GSE74704 | CD19 | 930 | 3 | 2 | 15 | |
| TCGA | CD19 | 930 | 20 | 12 | 64 |
Total number of gains: 100; Total number of losses: 50; Total Number of normals: 338.
Somatic mutations of CD19:
Generating mutation plots.
Highly correlated genes for CD19:
Showing top 20/296 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CD19 | FCRL3 | 0.828888 | 6 | 0 | 6 |
| CD19 | CLEC17A | 0.805935 | 3 | 0 | 3 |
| CD19 | MS4A1 | 0.79697 | 10 | 0 | 10 |
| CD19 | CD79B | 0.774987 | 9 | 0 | 9 |
| CD19 | EPHB1 | 0.74301 | 4 | 0 | 4 |
| CD19 | CD37 | 0.741287 | 11 | 0 | 11 |
| CD19 | LINC01215 | 0.738389 | 4 | 0 | 4 |
| CD19 | CR2 | 0.734748 | 11 | 0 | 10 |
| CD19 | BANK1 | 0.722237 | 9 | 0 | 9 |
| CD19 | SMOX | 0.719494 | 3 | 0 | 3 |
| CD19 | CD79A | 0.716281 | 11 | 0 | 11 |
| CD19 | IKZF3 | 0.712918 | 7 | 0 | 7 |
| CD19 | POU2AF1 | 0.712689 | 4 | 0 | 4 |
| CD19 | MED24 | 0.71129 | 3 | 0 | 3 |
| CD19 | RAPGEF1 | 0.709049 | 4 | 0 | 4 |
| CD19 | NAGLU | 0.705926 | 3 | 0 | 3 |
| CD19 | CD22 | 0.704799 | 12 | 0 | 11 |
| CD19 | BTLA | 0.701242 | 6 | 0 | 6 |
| CD19 | PNOC | 0.700245 | 8 | 0 | 7 |
| CD19 | DCXR | 0.699803 | 3 | 0 | 3 |
For details and further investigation, click here
