| Full name: Spi-B transcription factor | Alias Symbol: SPI-B | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 6689 | HGNC ID: HGNC:11242 | Ensembl Gene: ENSG00000269404 | OMIM ID: 606802 |
| Drug and gene relationship at DGIdb | |||
Expression of SPIB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPIB | 6689 | 205861_at | 0.1288 | 0.8915 | |
| GSE20347 | SPIB | 6689 | 205861_at | -0.0278 | 0.8688 | |
| GSE23400 | SPIB | 6689 | 205861_at | -0.0507 | 0.6273 | |
| GSE26886 | SPIB | 6689 | 205861_at | -0.0761 | 0.7936 | |
| GSE29001 | SPIB | 6689 | 205861_at | -0.1068 | 0.7024 | |
| GSE38129 | SPIB | 6689 | 205861_at | -0.1109 | 0.5940 | |
| GSE45670 | SPIB | 6689 | 205861_at | 0.1021 | 0.5416 | |
| GSE53622 | SPIB | 6689 | 22226 | -0.6446 | 0.0612 | |
| GSE53624 | SPIB | 6689 | 22226 | -1.5470 | 0.0000 | |
| GSE63941 | SPIB | 6689 | 205861_at | 0.1575 | 0.4896 | |
| GSE77861 | SPIB | 6689 | 205861_at | -0.1065 | 0.3141 | |
| GSE97050 | SPIB | 6689 | A_23_P39067 | -0.0232 | 0.9875 | |
| SRP007169 | SPIB | 6689 | RNAseq | 0.5427 | 0.4275 | |
| SRP064894 | SPIB | 6689 | RNAseq | 0.5490 | 0.0869 | |
| SRP133303 | SPIB | 6689 | RNAseq | -0.2208 | 0.2495 | |
| SRP159526 | SPIB | 6689 | RNAseq | -0.9700 | 0.1873 | |
| SRP193095 | SPIB | 6689 | RNAseq | 0.0486 | 0.8396 | |
| SRP219564 | SPIB | 6689 | RNAseq | -0.0379 | 0.9492 | |
| TCGA | SPIB | 6689 | RNAseq | -0.3291 | 0.5827 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SPIB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPIB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPIB | 6689 | 3 | 4 | 23 | |
| GSE20123 | SPIB | 6689 | 3 | 3 | 24 | |
| GSE43470 | SPIB | 6689 | 4 | 11 | 28 | |
| GSE46452 | SPIB | 6689 | 45 | 1 | 13 | |
| GSE47630 | SPIB | 6689 | 9 | 6 | 25 | |
| GSE54993 | SPIB | 6689 | 17 | 4 | 49 | |
| GSE54994 | SPIB | 6689 | 4 | 14 | 35 | |
| GSE60625 | SPIB | 6689 | 9 | 0 | 2 | |
| GSE74703 | SPIB | 6689 | 4 | 7 | 25 | |
| GSE74704 | SPIB | 6689 | 3 | 1 | 16 | |
| TCGA | SPIB | 6689 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of SPIB:
Generating mutation plots.
Highly correlated genes for SPIB:
Showing top 20/235 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPIB | EDA2R | 0.725011 | 3 | 0 | 3 |
| SPIB | DCHS2 | 0.711798 | 3 | 0 | 3 |
| SPIB | CRABP1 | 0.709264 | 3 | 0 | 3 |
| SPIB | CD79A | 0.709102 | 8 | 0 | 7 |
| SPIB | CD79B | 0.695407 | 7 | 0 | 5 |
| SPIB | BANK1 | 0.693863 | 7 | 0 | 6 |
| SPIB | BTLA | 0.686886 | 5 | 0 | 4 |
| SPIB | FCRL2 | 0.685388 | 4 | 0 | 4 |
| SPIB | PNOC | 0.682455 | 6 | 0 | 5 |
| SPIB | IRF4 | 0.670247 | 7 | 0 | 6 |
| SPIB | LINC01215 | 0.661532 | 5 | 0 | 3 |
| SPIB | IGK | 0.661015 | 4 | 0 | 3 |
| SPIB | DOK5 | 0.660276 | 4 | 0 | 3 |
| SPIB | FCRL3 | 0.656422 | 7 | 0 | 6 |
| SPIB | BLK | 0.650538 | 6 | 0 | 4 |
| SPIB | NCR3 | 0.650043 | 4 | 0 | 3 |
| SPIB | CD27 | 0.643293 | 7 | 0 | 5 |
| SPIB | AMBN | 0.643218 | 4 | 0 | 3 |
| SPIB | THEMIS | 0.640195 | 3 | 0 | 3 |
| SPIB | ERCC1 | 0.636858 | 3 | 0 | 3 |
For details and further investigation, click here
