CREB3L2

 

Full name: cAMP responsive element binding protein 3 like 2 Alias Symbol: BBF2H7|TCAG_1951439
Type: protein-coding gene Cytoband: 7q33
Entrez ID: 64764 HGNC ID: HGNC:23720 Ensembl Gene: ENSG00000182158 OMIM ID: 608834
Drug and gene relationship at DGIdb

 

CREB3L2 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04668TNF signaling pathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04911Insulin secretion
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04922Glucagon signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04931Insulin resistance
hsa04962Vasopressin-regulated water reabsorption
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05161Hepatitis B
hsa05215Prostate cancer

 

Expression of CREB3L2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREB3L2 64764 212345_s_at -0.4747 0.3134
GSE20347 CREB3L2 64764 212345_s_at -0.5953 0.0001
GSE23400 CREB3L2 64764 212345_s_at -0.4445 0.0000
GSE26886 CREB3L2 64764 212345_s_at -1.5756 0.0000
GSE29001 CREB3L2 64764 212345_s_at -0.5720 0.0486
GSE38129 CREB3L2 64764 212345_s_at -0.5341 0.0000
GSE45670 CREB3L2 64764 212345_s_at -0.4107 0.0804
GSE53622 CREB3L2 64764 111367 -0.2234 0.0004
GSE53624 CREB3L2 64764 23436 -0.3570 0.0000
GSE63941 CREB3L2 64764 212345_s_at -2.5833 0.0012
GSE77861 CREB3L2 64764 212345_s_at -0.1490 0.7092
GSE97050 CREB3L2 64764 A_33_P3320888 0.4357 0.1882
SRP007169 CREB3L2 64764 RNAseq -0.1032 0.8215
SRP008496 CREB3L2 64764 RNAseq -0.1501 0.6238
SRP064894 CREB3L2 64764 RNAseq 0.0972 0.6442
SRP133303 CREB3L2 64764 RNAseq 0.0561 0.7950
SRP159526 CREB3L2 64764 RNAseq 0.0168 0.9523
SRP193095 CREB3L2 64764 RNAseq -0.0916 0.6175
SRP219564 CREB3L2 64764 RNAseq 0.0606 0.8613
TCGA CREB3L2 64764 RNAseq -0.2384 0.0000

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by CREB3L2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREB3L2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREB3L2 64764 5 2 23
GSE20123 CREB3L2 64764 5 2 23
GSE43470 CREB3L2 64764 2 3 38
GSE46452 CREB3L2 64764 7 2 50
GSE47630 CREB3L2 64764 7 4 29
GSE54993 CREB3L2 64764 3 5 62
GSE54994 CREB3L2 64764 6 8 39
GSE60625 CREB3L2 64764 0 0 11
GSE74703 CREB3L2 64764 2 3 31
GSE74704 CREB3L2 64764 2 2 16
TCGA CREB3L2 64764 28 23 45

Total number of gains: 67; Total number of losses: 54; Total Number of normals: 367.  

 

Somatic mutations of CREB3L2:

 

Generating mutation plots.

 

Highly correlated genes for CREB3L2:

 

Showing top 20/716 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREB3L2ZNF5830.74824303
CREB3L2FKBP70.747402303
CREB3L2CYP4V20.747351303
CREB3L2FNIP20.739123404
CREB3L2CD1640.732034303
CREB3L2ERLEC10.728681403
CREB3L2SLC39A70.727303303
CREB3L2FAM120AOS0.725991303
CREB3L2MICAL10.723193303
CREB3L2SLC24A10.723024303
CREB3L2PGBD40.701759303
CREB3L2DOCK10.701204303
CREB3L2AKT30.700846303
CREB3L2TMX30.689937303
CREB3L2PDZRN3-AS10.682922303
CREB3L2CNP0.681438504
CREB3L2TSHZ20.678088303
CREB3L2XBP10.671667303
CREB3L2SCAF80.670301303
CREB3L2DOK60.669162403

For details and further investigation, click here