| Full name: X-box binding protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q12.1 | ||
| Entrez ID: 7494 | HGNC ID: HGNC:12801 | Ensembl Gene: ENSG00000100219 | OMIM ID: 194355 |
| Drug and gene relationship at DGIdb | |||
XBP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | |
| hsa05166 | HTLV-I infection |
Expression of XBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XBP1 | 7494 | 200670_at | -0.0830 | 0.9219 | |
| GSE20347 | XBP1 | 7494 | 200670_at | 0.0872 | 0.6143 | |
| GSE23400 | XBP1 | 7494 | 200670_at | 0.1084 | 0.2195 | |
| GSE26886 | XBP1 | 7494 | 200670_at | -0.5677 | 0.0167 | |
| GSE29001 | XBP1 | 7494 | 200670_at | -0.0479 | 0.9050 | |
| GSE38129 | XBP1 | 7494 | 200670_at | 0.2663 | 0.1386 | |
| GSE45670 | XBP1 | 7494 | 200670_at | 0.2953 | 0.2586 | |
| GSE63941 | XBP1 | 7494 | 200670_at | 0.5212 | 0.3150 | |
| GSE77861 | XBP1 | 7494 | 200670_at | 0.1929 | 0.5668 | |
| GSE97050 | XBP1 | 7494 | A_23_P120845 | 0.9013 | 0.1623 | |
| SRP007169 | XBP1 | 7494 | RNAseq | -0.2190 | 0.5330 | |
| SRP008496 | XBP1 | 7494 | RNAseq | -0.2381 | 0.1967 | |
| SRP064894 | XBP1 | 7494 | RNAseq | -0.4655 | 0.1682 | |
| SRP133303 | XBP1 | 7494 | RNAseq | 0.2149 | 0.5047 | |
| SRP159526 | XBP1 | 7494 | RNAseq | 0.3922 | 0.4616 | |
| SRP193095 | XBP1 | 7494 | RNAseq | -0.0939 | 0.7210 | |
| SRP219564 | XBP1 | 7494 | RNAseq | 0.5569 | 0.1719 | |
| TCGA | XBP1 | 7494 | RNAseq | -0.3842 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by XBP1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of XBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XBP1 | 7494 | 3 | 3 | 24 | |
| GSE20123 | XBP1 | 7494 | 3 | 2 | 25 | |
| GSE43470 | XBP1 | 7494 | 3 | 6 | 34 | |
| GSE46452 | XBP1 | 7494 | 31 | 1 | 27 | |
| GSE47630 | XBP1 | 7494 | 8 | 5 | 27 | |
| GSE54993 | XBP1 | 7494 | 3 | 6 | 61 | |
| GSE54994 | XBP1 | 7494 | 11 | 8 | 34 | |
| GSE60625 | XBP1 | 7494 | 5 | 0 | 6 | |
| GSE74703 | XBP1 | 7494 | 3 | 5 | 28 | |
| GSE74704 | XBP1 | 7494 | 0 | 1 | 19 | |
| TCGA | XBP1 | 7494 | 26 | 15 | 55 |
Total number of gains: 96; Total number of losses: 52; Total Number of normals: 340.
Somatic mutations of XBP1:
Generating mutation plots.
Highly correlated genes for XBP1:
Showing top 20/194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XBP1 | ASCC3 | 0.776105 | 3 | 0 | 3 |
| XBP1 | CD79B | 0.77051 | 3 | 0 | 3 |
| XBP1 | RRAGB | 0.767683 | 3 | 0 | 3 |
| XBP1 | P2RY13 | 0.761647 | 3 | 0 | 3 |
| XBP1 | INPP5D | 0.750831 | 3 | 0 | 3 |
| XBP1 | SNX20 | 0.740935 | 3 | 0 | 3 |
| XBP1 | SMAP2 | 0.740364 | 3 | 0 | 3 |
| XBP1 | MFN1 | 0.737544 | 3 | 0 | 3 |
| XBP1 | ORC4 | 0.725545 | 3 | 0 | 3 |
| XBP1 | TMEM150C | 0.724705 | 3 | 0 | 3 |
| XBP1 | CSF1R | 0.704081 | 3 | 0 | 3 |
| XBP1 | C3orf80 | 0.701827 | 3 | 0 | 3 |
| XBP1 | BMPR2 | 0.699493 | 3 | 0 | 3 |
| XBP1 | FCGBP | 0.691457 | 3 | 0 | 3 |
| XBP1 | SETX | 0.688542 | 3 | 0 | 3 |
| XBP1 | IER3IP1 | 0.683025 | 5 | 0 | 4 |
| XBP1 | SURF4 | 0.674171 | 4 | 0 | 3 |
| XBP1 | USP3 | 0.673156 | 4 | 0 | 4 |
| XBP1 | IST1 | 0.671988 | 4 | 0 | 4 |
| XBP1 | CREB3L2 | 0.671667 | 3 | 0 | 3 |
For details and further investigation, click here
