| Full name: ankyrin 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q21.2 | ||
| Entrez ID: 288 | HGNC ID: HGNC:494 | Ensembl Gene: ENSG00000151150 | OMIM ID: 600465 |
| Drug and gene relationship at DGIdb | |||
ANK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of ANK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANK3 | 288 | 206385_s_at | -0.4025 | 0.2838 | |
| GSE20347 | ANK3 | 288 | 206385_s_at | -0.6782 | 0.0024 | |
| GSE23400 | ANK3 | 288 | 206385_s_at | -0.4416 | 0.0048 | |
| GSE26886 | ANK3 | 288 | 206385_s_at | -0.5479 | 0.2419 | |
| GSE29001 | ANK3 | 288 | 206385_s_at | -0.4078 | 0.2521 | |
| GSE38129 | ANK3 | 288 | 206385_s_at | -0.5591 | 0.0031 | |
| GSE45670 | ANK3 | 288 | 206385_s_at | -0.0682 | 0.7677 | |
| GSE53622 | ANK3 | 288 | 33760 | -0.5662 | 0.0000 | |
| GSE53624 | ANK3 | 288 | 17035 | -0.5974 | 0.0000 | |
| GSE63941 | ANK3 | 288 | 206385_s_at | 5.6269 | 0.0001 | |
| GSE77861 | ANK3 | 288 | 206385_s_at | 0.4334 | 0.1370 | |
| GSE97050 | ANK3 | 288 | A_24_P162173 | -0.4771 | 0.2836 | |
| SRP007169 | ANK3 | 288 | RNAseq | 0.1057 | 0.8605 | |
| SRP008496 | ANK3 | 288 | RNAseq | 0.1667 | 0.6195 | |
| SRP064894 | ANK3 | 288 | RNAseq | -0.6001 | 0.0289 | |
| SRP133303 | ANK3 | 288 | RNAseq | -0.9008 | 0.0002 | |
| SRP159526 | ANK3 | 288 | RNAseq | -0.6408 | 0.0828 | |
| SRP193095 | ANK3 | 288 | RNAseq | -0.4854 | 0.0005 | |
| SRP219564 | ANK3 | 288 | RNAseq | -0.6419 | 0.1180 | |
| TCGA | ANK3 | 288 | RNAseq | -0.1748 | 0.0450 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ANK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANK3 | 288 | 2 | 7 | 21 | |
| GSE20123 | ANK3 | 288 | 3 | 7 | 20 | |
| GSE43470 | ANK3 | 288 | 2 | 5 | 36 | |
| GSE46452 | ANK3 | 288 | 1 | 11 | 47 | |
| GSE47630 | ANK3 | 288 | 4 | 12 | 24 | |
| GSE54993 | ANK3 | 288 | 9 | 0 | 61 | |
| GSE54994 | ANK3 | 288 | 3 | 9 | 41 | |
| GSE60625 | ANK3 | 288 | 0 | 0 | 11 | |
| GSE74703 | ANK3 | 288 | 2 | 3 | 31 | |
| GSE74704 | ANK3 | 288 | 1 | 5 | 14 | |
| TCGA | ANK3 | 288 | 11 | 24 | 61 |
Total number of gains: 38; Total number of losses: 83; Total Number of normals: 367.
Somatic mutations of ANK3:
Generating mutation plots.
Highly correlated genes for ANK3:
Showing top 20/102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANK3 | FAM110C | 0.760859 | 3 | 0 | 3 |
| ANK3 | EMILIN3 | 0.736335 | 3 | 0 | 3 |
| ANK3 | NUDT21 | 0.686861 | 3 | 0 | 3 |
| ANK3 | ATL2 | 0.632648 | 5 | 0 | 4 |
| ANK3 | AKAP13 | 0.630157 | 3 | 0 | 3 |
| ANK3 | LEAP2 | 0.629132 | 4 | 0 | 4 |
| ANK3 | COL21A1 | 0.625697 | 3 | 0 | 3 |
| ANK3 | DEAF1 | 0.605892 | 3 | 0 | 3 |
| ANK3 | PGGT1B | 0.593531 | 4 | 0 | 3 |
| ANK3 | DLAT | 0.592833 | 4 | 0 | 3 |
| ANK3 | SERPINB1 | 0.590989 | 5 | 0 | 3 |
| ANK3 | SUSD4 | 0.588732 | 10 | 0 | 8 |
| ANK3 | PPP1R2 | 0.587148 | 4 | 0 | 4 |
| ANK3 | CREB3L4 | 0.58544 | 4 | 0 | 3 |
| ANK3 | SERPINB3 | 0.584424 | 5 | 0 | 3 |
| ANK3 | C1orf56 | 0.580526 | 5 | 0 | 3 |
| ANK3 | CETN3 | 0.580323 | 5 | 0 | 3 |
| ANK3 | MRPL10 | 0.578003 | 3 | 0 | 3 |
| ANK3 | AGGF1 | 0.575594 | 4 | 0 | 3 |
| ANK3 | NET1 | 0.575442 | 7 | 0 | 4 |
For details and further investigation, click here
