FZD3

 

Full name: frizzled class receptor 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 8p21.1
Entrez ID: 7976 HGNC ID: HGNC:4041 Ensembl Gene: ENSG00000104290 OMIM ID: 606143
Drug and gene relationship at DGIdb

 

FZD3 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of FZD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FZD3 7976 239082_at 0.4750 0.4665
GSE20347 FZD3 7976 219683_at 0.6936 0.0000
GSE23400 FZD3 7976 219683_at 0.1781 0.0159
GSE26886 FZD3 7976 239082_at 1.7949 0.0000
GSE29001 FZD3 7976 219683_at 0.4741 0.1581
GSE38129 FZD3 7976 219683_at 0.4951 0.0030
GSE45670 FZD3 7976 239082_at 0.2141 0.5359
GSE53622 FZD3 7976 25907 0.1519 0.3665
GSE53624 FZD3 7976 25907 0.2950 0.0104
GSE63941 FZD3 7976 239082_at 3.0508 0.0003
GSE77861 FZD3 7976 239082_at 1.0232 0.0851
GSE97050 FZD3 7976 A_23_P347468 -0.3409 0.5059
SRP007169 FZD3 7976 RNAseq 0.3021 0.5915
SRP008496 FZD3 7976 RNAseq 0.6057 0.0814
SRP064894 FZD3 7976 RNAseq 0.2458 0.1852
SRP133303 FZD3 7976 RNAseq 0.5885 0.0011
SRP159526 FZD3 7976 RNAseq 0.9993 0.0080
SRP193095 FZD3 7976 RNAseq 0.8819 0.0000
SRP219564 FZD3 7976 RNAseq -0.2178 0.6263
TCGA FZD3 7976 RNAseq -0.1879 0.1289

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by FZD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FZD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FZD3 7976 4 10 16
GSE20123 FZD3 7976 4 10 16
GSE43470 FZD3 7976 4 7 32
GSE46452 FZD3 7976 13 13 33
GSE47630 FZD3 7976 10 8 22
GSE54993 FZD3 7976 2 15 53
GSE54994 FZD3 7976 10 15 28
GSE60625 FZD3 7976 3 0 8
GSE74703 FZD3 7976 4 6 26
GSE74704 FZD3 7976 3 7 10
TCGA FZD3 7976 17 42 37

Total number of gains: 74; Total number of losses: 133; Total Number of normals: 281.  

 

Somatic mutations of FZD3:

 

Generating mutation plots.

 

Highly correlated genes for FZD3:

 

Showing top 20/733 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FZD3RICTOR0.756153303
FZD3CMTM40.751657303
FZD3MED300.735623505
FZD3KCNE30.714113303
FZD3LIFR0.711301404
FZD3GDE10.707827303
FZD3LSM100.698795303
FZD3SMARCA50.698619404
FZD3PMPCB0.697179504
FZD3RAD51-AS10.696495303
FZD3LNP10.696438303
FZD3ZIC20.69457303
FZD3NDUFV10.685441303
FZD3IFT1720.683683303
FZD3NUP2100.681817404
FZD3RRM10.679857303
FZD3CTXN10.676582303
FZD3MPLKIP0.672258303
FZD3COL28A10.670319403
FZD3RILPL20.666504403

For details and further investigation, click here