CREM

 

Full name: cAMP responsive element modulator Alias Symbol: hCREM-2
Type: protein-coding gene Cytoband: 10p11.21
Entrez ID: 1390 HGNC ID: HGNC:2352 Ensembl Gene: ENSG00000095794 OMIM ID: 123812
Drug and gene relationship at DGIdb

 

CREM involved pathways:

KEGG pathway Description View
hsa04261Adrenergic signaling in cardiomyocytes
hsa05166HTLV-I infection

 

Expression of CREM:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CREM 1390 207630_s_at 0.2947 0.5315
GSE20347 CREM 1390 209967_s_at 0.2892 0.1661
GSE23400 CREM 1390 214508_x_at -0.0132 0.8347
GSE26886 CREM 1390 209967_s_at 0.9144 0.0019
GSE29001 CREM 1390 209967_s_at 0.9718 0.0162
GSE38129 CREM 1390 209967_s_at 0.0055 0.9859
GSE45670 CREM 1390 209967_s_at 0.0219 0.9553
GSE53622 CREM 1390 30878 -0.0401 0.7833
GSE53624 CREM 1390 30878 0.3186 0.0008
GSE63941 CREM 1390 207630_s_at -0.3310 0.7207
GSE77861 CREM 1390 214508_x_at 0.1864 0.3408
GSE97050 CREM 1390 A_23_P201979 0.1016 0.7371
SRP007169 CREM 1390 RNAseq 0.6933 0.0819
SRP008496 CREM 1390 RNAseq 1.1492 0.0011
SRP064894 CREM 1390 RNAseq 0.3083 0.1759
SRP133303 CREM 1390 RNAseq 0.9017 0.0014
SRP159526 CREM 1390 RNAseq 0.2580 0.4553
SRP193095 CREM 1390 RNAseq 0.4969 0.0005
SRP219564 CREM 1390 RNAseq 0.3636 0.3929
TCGA CREM 1390 RNAseq -0.1117 0.1388

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CREM expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CREM:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CREM 1390 4 7 19
GSE20123 CREM 1390 4 6 20
GSE43470 CREM 1390 3 3 37
GSE46452 CREM 1390 2 13 44
GSE47630 CREM 1390 7 10 23
GSE54993 CREM 1390 8 1 61
GSE54994 CREM 1390 2 10 41
GSE60625 CREM 1390 0 0 11
GSE74703 CREM 1390 2 1 33
GSE74704 CREM 1390 0 5 15
TCGA CREM 1390 17 24 55

Total number of gains: 49; Total number of losses: 80; Total Number of normals: 359.  

 

Somatic mutations of CREM:

 

Generating mutation plots.

 

Highly correlated genes for CREM:

 

Showing top 20/903 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CREMPOLR2B0.735799303
CREMC3orf330.733999303
CREMPRELID20.722818303
CREMHIC10.717825505
CREMUBA20.711793303
CREMZFHX30.701913303
CREMFXR10.700011404
CREMC19orf380.695455303
CREMACTL6A0.691462404
CREMCNIH30.691355303
CREMSULT1A20.690379303
CREMMRPL470.690328303
CREMZNF8270.689133303
CREMCCDC590.688013403
CREMGRAMD1A0.686063505
CREMZDHHC70.684169303
CREMIL330.682896303
CREMRAB8B0.681059505
CREMTEAD20.680657403
CREMKCNAB20.679474403

For details and further investigation, click here