| Full name: interleukin 33 | Alias Symbol: DVS27|DKFZp586H0523|NF-HEV|IL1F11 | ||
| Type: protein-coding gene | Cytoband: 9p24.1 | ||
| Entrez ID: 90865 | HGNC ID: HGNC:16028 | Ensembl Gene: ENSG00000137033 | OMIM ID: 608678 |
| Drug and gene relationship at DGIdb | |||
IL33 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05164 | Influenza A |
Expression of IL33:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL33 | 90865 | 209821_at | -1.5194 | 0.0400 | |
| GSE20347 | IL33 | 90865 | 209821_at | -0.9626 | 0.0026 | |
| GSE23400 | IL33 | 90865 | 209821_at | -0.3327 | 0.0135 | |
| GSE26886 | IL33 | 90865 | 209821_at | -0.6814 | 0.2807 | |
| GSE29001 | IL33 | 90865 | 209821_at | -0.7979 | 0.0800 | |
| GSE38129 | IL33 | 90865 | 209821_at | -1.8518 | 0.0000 | |
| GSE45670 | IL33 | 90865 | 209821_at | -1.5086 | 0.0379 | |
| GSE53622 | IL33 | 90865 | 105173 | -2.5063 | 0.0000 | |
| GSE53624 | IL33 | 90865 | 105173 | -2.4373 | 0.0000 | |
| GSE63941 | IL33 | 90865 | 209821_at | -6.3946 | 0.0000 | |
| GSE77861 | IL33 | 90865 | 209821_at | -0.2421 | 0.1033 | |
| GSE97050 | IL33 | 90865 | A_23_P31945 | -0.4103 | 0.2799 | |
| SRP007169 | IL33 | 90865 | RNAseq | -0.5034 | 0.4706 | |
| SRP064894 | IL33 | 90865 | RNAseq | -0.4148 | 0.3943 | |
| SRP133303 | IL33 | 90865 | RNAseq | -2.3208 | 0.0000 | |
| SRP159526 | IL33 | 90865 | RNAseq | -1.6675 | 0.0323 | |
| SRP193095 | IL33 | 90865 | RNAseq | -0.5550 | 0.1949 | |
| SRP219564 | IL33 | 90865 | RNAseq | -1.1534 | 0.2606 | |
| TCGA | IL33 | 90865 | RNAseq | -1.2312 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by IL33 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL33:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL33 | 90865 | 1 | 17 | 12 | |
| GSE20123 | IL33 | 90865 | 1 | 17 | 12 | |
| GSE43470 | IL33 | 90865 | 5 | 11 | 27 | |
| GSE46452 | IL33 | 90865 | 2 | 23 | 34 | |
| GSE47630 | IL33 | 90865 | 5 | 26 | 9 | |
| GSE54993 | IL33 | 90865 | 6 | 3 | 61 | |
| GSE54994 | IL33 | 90865 | 9 | 16 | 28 | |
| GSE60625 | IL33 | 90865 | 0 | 2 | 9 | |
| GSE74703 | IL33 | 90865 | 5 | 8 | 23 | |
| GSE74704 | IL33 | 90865 | 0 | 13 | 7 | |
| TCGA | IL33 | 90865 | 14 | 51 | 31 |
Total number of gains: 48; Total number of losses: 187; Total Number of normals: 253.
Somatic mutations of IL33:
Generating mutation plots.
Highly correlated genes for IL33:
Showing top 20/1353 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL33 | DOK6 | 0.889862 | 3 | 0 | 3 |
| IL33 | CLEC3B | 0.816613 | 3 | 0 | 3 |
| IL33 | ZNF407 | 0.810349 | 3 | 0 | 3 |
| IL33 | CYP21A2 | 0.789282 | 3 | 0 | 3 |
| IL33 | GMPR | 0.781744 | 3 | 0 | 3 |
| IL33 | SORCS1 | 0.776494 | 4 | 0 | 4 |
| IL33 | CYP4V2 | 0.775592 | 4 | 0 | 4 |
| IL33 | ACKR4 | 0.769995 | 3 | 0 | 3 |
| IL33 | PRPH2 | 0.76802 | 4 | 0 | 4 |
| IL33 | ARHGAP20 | 0.7667 | 4 | 0 | 4 |
| IL33 | ANKHD1 | 0.765872 | 3 | 0 | 3 |
| IL33 | ENG | 0.758487 | 4 | 0 | 4 |
| IL33 | CCL14 | 0.754883 | 3 | 0 | 3 |
| IL33 | ABCA8 | 0.748358 | 11 | 0 | 10 |
| IL33 | MRVI1 | 0.746526 | 6 | 0 | 5 |
| IL33 | IFFO1 | 0.746486 | 4 | 0 | 4 |
| IL33 | TSHZ3 | 0.746082 | 3 | 0 | 3 |
| IL33 | TBC1D20 | 0.743299 | 3 | 0 | 3 |
| IL33 | KCNB1 | 0.740387 | 4 | 0 | 4 |
| IL33 | RSPO2 | 0.733919 | 3 | 0 | 3 |
For details and further investigation, click here
