| Full name: RNA polymerase II subunit B | Alias Symbol: RPB2 | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 5431 | HGNC ID: HGNC:9188 | Ensembl Gene: ENSG00000047315 | OMIM ID: 180661 |
| Drug and gene relationship at DGIdb | |||
Expression of POLR2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POLR2B | 5431 | 1555837_s_at | 0.3354 | 0.2849 | |
| GSE20347 | POLR2B | 5431 | 201803_at | 0.2105 | 0.0269 | |
| GSE23400 | POLR2B | 5431 | 201803_at | 0.3798 | 0.0000 | |
| GSE26886 | POLR2B | 5431 | 1555837_s_at | -0.0785 | 0.7148 | |
| GSE29001 | POLR2B | 5431 | 201803_at | 0.2470 | 0.2270 | |
| GSE38129 | POLR2B | 5431 | 201803_at | 0.3345 | 0.0046 | |
| GSE45670 | POLR2B | 5431 | 1555837_s_at | 0.1811 | 0.4942 | |
| GSE53622 | POLR2B | 5431 | 12967 | 0.3018 | 0.0000 | |
| GSE53624 | POLR2B | 5431 | 12967 | 0.2995 | 0.0000 | |
| GSE63941 | POLR2B | 5431 | 1555837_s_at | -0.3288 | 0.3839 | |
| GSE77861 | POLR2B | 5431 | 1555837_s_at | 0.2077 | 0.6227 | |
| GSE97050 | POLR2B | 5431 | A_23_P144311 | 0.0060 | 0.9821 | |
| SRP007169 | POLR2B | 5431 | RNAseq | -0.0027 | 0.9945 | |
| SRP008496 | POLR2B | 5431 | RNAseq | 0.1819 | 0.3675 | |
| SRP064894 | POLR2B | 5431 | RNAseq | 0.1115 | 0.5859 | |
| SRP133303 | POLR2B | 5431 | RNAseq | 0.4894 | 0.0025 | |
| SRP159526 | POLR2B | 5431 | RNAseq | 0.1046 | 0.5232 | |
| SRP193095 | POLR2B | 5431 | RNAseq | 0.0727 | 0.4837 | |
| SRP219564 | POLR2B | 5431 | RNAseq | -0.2372 | 0.3566 | |
| TCGA | POLR2B | 5431 | RNAseq | 0.0206 | 0.6381 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POLR2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POLR2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POLR2B | 5431 | 3 | 12 | 15 | |
| GSE20123 | POLR2B | 5431 | 2 | 12 | 16 | |
| GSE43470 | POLR2B | 5431 | 0 | 14 | 29 | |
| GSE46452 | POLR2B | 5431 | 1 | 36 | 22 | |
| GSE47630 | POLR2B | 5431 | 0 | 19 | 21 | |
| GSE54993 | POLR2B | 5431 | 7 | 0 | 63 | |
| GSE54994 | POLR2B | 5431 | 2 | 10 | 41 | |
| GSE60625 | POLR2B | 5431 | 0 | 0 | 11 | |
| GSE74703 | POLR2B | 5431 | 0 | 12 | 24 | |
| GSE74704 | POLR2B | 5431 | 1 | 7 | 12 | |
| TCGA | POLR2B | 5431 | 20 | 26 | 50 |
Total number of gains: 36; Total number of losses: 148; Total Number of normals: 304.
Somatic mutations of POLR2B:
Generating mutation plots.
Highly correlated genes for POLR2B:
Showing top 20/698 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POLR2B | C8orf76 | 0.856552 | 3 | 0 | 3 |
| POLR2B | C6orf62 | 0.807419 | 3 | 0 | 3 |
| POLR2B | C12orf73 | 0.782524 | 3 | 0 | 3 |
| POLR2B | SDHB | 0.764261 | 3 | 0 | 3 |
| POLR2B | PPHLN1 | 0.763249 | 4 | 0 | 4 |
| POLR2B | ZNF121 | 0.74878 | 3 | 0 | 3 |
| POLR2B | CREM | 0.735799 | 3 | 0 | 3 |
| POLR2B | MGMT | 0.733665 | 3 | 0 | 3 |
| POLR2B | ZMYND19 | 0.732544 | 3 | 0 | 3 |
| POLR2B | PMPCB | 0.730507 | 3 | 0 | 3 |
| POLR2B | LRRCC1 | 0.729335 | 3 | 0 | 3 |
| POLR2B | GNA11 | 0.729059 | 3 | 0 | 3 |
| POLR2B | CALML5 | 0.722838 | 3 | 0 | 3 |
| POLR2B | HAUS1 | 0.71611 | 3 | 0 | 3 |
| POLR2B | RAB34 | 0.713811 | 3 | 0 | 3 |
| POLR2B | SFR1 | 0.710711 | 3 | 0 | 3 |
| POLR2B | PATL1 | 0.709805 | 3 | 0 | 3 |
| POLR2B | ELOF1 | 0.709686 | 3 | 0 | 3 |
| POLR2B | PIGU | 0.708996 | 5 | 0 | 4 |
| POLR2B | SRP72 | 0.708464 | 10 | 0 | 9 |
For details and further investigation, click here
