| Full name: CREB regulated transcription coactivator 3 | Alias Symbol: FLJ21868 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 64784 | HGNC ID: HGNC:26148 | Ensembl Gene: ENSG00000140577 | OMIM ID: 608986 |
| Drug and gene relationship at DGIdb | |||
CRTC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05166 | HTLV-I infection |
Expression of CRTC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CRTC3 | 64784 | 218648_at | -0.1766 | 0.7727 | |
| GSE20347 | CRTC3 | 64784 | 218648_at | 0.5302 | 0.0147 | |
| GSE23400 | CRTC3 | 64784 | 218648_at | 0.0748 | 0.3834 | |
| GSE26886 | CRTC3 | 64784 | 218648_at | 0.8479 | 0.0001 | |
| GSE29001 | CRTC3 | 64784 | 218648_at | 0.5503 | 0.0227 | |
| GSE38129 | CRTC3 | 64784 | 218648_at | 0.1572 | 0.4957 | |
| GSE45670 | CRTC3 | 64784 | 218648_at | -0.3697 | 0.1146 | |
| GSE53622 | CRTC3 | 64784 | 82439 | -0.0150 | 0.8736 | |
| GSE53624 | CRTC3 | 64784 | 82439 | 0.0783 | 0.4186 | |
| GSE63941 | CRTC3 | 64784 | 218648_at | -0.7638 | 0.0799 | |
| GSE77861 | CRTC3 | 64784 | 218648_at | 0.4285 | 0.0683 | |
| GSE97050 | CRTC3 | 64784 | A_23_P77228 | -0.4384 | 0.2466 | |
| SRP007169 | CRTC3 | 64784 | RNAseq | 0.7048 | 0.0564 | |
| SRP008496 | CRTC3 | 64784 | RNAseq | 0.7178 | 0.0170 | |
| SRP064894 | CRTC3 | 64784 | RNAseq | 0.0760 | 0.6799 | |
| SRP133303 | CRTC3 | 64784 | RNAseq | 0.0324 | 0.8497 | |
| SRP159526 | CRTC3 | 64784 | RNAseq | 0.2190 | 0.2890 | |
| SRP193095 | CRTC3 | 64784 | RNAseq | 0.6378 | 0.0000 | |
| SRP219564 | CRTC3 | 64784 | RNAseq | 0.3494 | 0.4513 | |
| TCGA | CRTC3 | 64784 | RNAseq | -0.0668 | 0.1803 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CRTC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CRTC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CRTC3 | 64784 | 8 | 2 | 20 | |
| GSE20123 | CRTC3 | 64784 | 8 | 2 | 20 | |
| GSE43470 | CRTC3 | 64784 | 5 | 5 | 33 | |
| GSE46452 | CRTC3 | 64784 | 3 | 7 | 49 | |
| GSE47630 | CRTC3 | 64784 | 8 | 11 | 21 | |
| GSE54993 | CRTC3 | 64784 | 4 | 6 | 60 | |
| GSE54994 | CRTC3 | 64784 | 7 | 9 | 37 | |
| GSE60625 | CRTC3 | 64784 | 4 | 0 | 7 | |
| GSE74703 | CRTC3 | 64784 | 4 | 4 | 28 | |
| GSE74704 | CRTC3 | 64784 | 4 | 2 | 14 | |
| TCGA | CRTC3 | 64784 | 18 | 12 | 66 |
Total number of gains: 73; Total number of losses: 60; Total Number of normals: 355.
Somatic mutations of CRTC3:
Generating mutation plots.
Highly correlated genes for CRTC3:
Showing top 20/1022 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CRTC3 | PHIP | 0.770853 | 3 | 0 | 3 |
| CRTC3 | RABEPK | 0.71625 | 3 | 0 | 3 |
| CRTC3 | DNM1L | 0.716085 | 4 | 0 | 3 |
| CRTC3 | NOM1 | 0.706716 | 3 | 0 | 3 |
| CRTC3 | SNAPIN | 0.700101 | 4 | 0 | 3 |
| CRTC3 | UVRAG | 0.699292 | 4 | 0 | 4 |
| CRTC3 | PPP1R35 | 0.695759 | 3 | 0 | 3 |
| CRTC3 | TMED8 | 0.694818 | 3 | 0 | 3 |
| CRTC3 | PIGC | 0.693247 | 3 | 0 | 3 |
| CRTC3 | KIAA0895 | 0.692436 | 3 | 0 | 3 |
| CRTC3 | DHRSX | 0.68426 | 4 | 0 | 4 |
| CRTC3 | LNP1 | 0.682567 | 3 | 0 | 3 |
| CRTC3 | BRAT1 | 0.678788 | 3 | 0 | 3 |
| CRTC3 | TPPP3 | 0.678379 | 3 | 0 | 3 |
| CRTC3 | HERC2 | 0.678235 | 7 | 0 | 6 |
| CRTC3 | PKN3 | 0.678153 | 3 | 0 | 3 |
| CRTC3 | FAM20C | 0.677754 | 3 | 0 | 3 |
| CRTC3 | ZMYM3 | 0.67622 | 3 | 0 | 3 |
| CRTC3 | SFT2D3 | 0.670787 | 3 | 0 | 3 |
| CRTC3 | RPAP1 | 0.668828 | 3 | 0 | 3 |
For details and further investigation, click here
