| Full name: BRCA1 associated ATM activator 1 | Alias Symbol: MGC22916 | ||
| Type: protein-coding gene | Cytoband: 7p22.3 | ||
| Entrez ID: 221927 | HGNC ID: HGNC:21701 | Ensembl Gene: ENSG00000106009 | OMIM ID: 614506 |
Screen Evidence:
| |||
Expression of BRAT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRAT1 | 221927 | 225437_s_at | 0.7804 | 0.1004 | |
| GSE26886 | BRAT1 | 221927 | 225437_s_at | 1.2267 | 0.0000 | |
| GSE45670 | BRAT1 | 221927 | 225437_s_at | 0.4374 | 0.0036 | |
| GSE53622 | BRAT1 | 221927 | 86965 | 0.6532 | 0.0000 | |
| GSE53624 | BRAT1 | 221927 | 86965 | 1.0434 | 0.0000 | |
| GSE63941 | BRAT1 | 221927 | 225437_s_at | 0.6266 | 0.1321 | |
| GSE77861 | BRAT1 | 221927 | 225437_s_at | 0.5037 | 0.0137 | |
| GSE97050 | BRAT1 | 221927 | A_23_P251893 | 0.3493 | 0.1936 | |
| SRP007169 | BRAT1 | 221927 | RNAseq | 1.2891 | 0.0131 | |
| SRP008496 | BRAT1 | 221927 | RNAseq | 1.1594 | 0.0008 | |
| SRP064894 | BRAT1 | 221927 | RNAseq | 1.1422 | 0.0000 | |
| SRP133303 | BRAT1 | 221927 | RNAseq | 0.6087 | 0.0007 | |
| SRP159526 | BRAT1 | 221927 | RNAseq | 1.0124 | 0.0009 | |
| SRP193095 | BRAT1 | 221927 | RNAseq | 0.8557 | 0.0000 | |
| SRP219564 | BRAT1 | 221927 | RNAseq | 1.1723 | 0.0279 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by BRAT1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of BRAT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRAT1 | 221927 | 14 | 0 | 16 | |
| GSE20123 | BRAT1 | 221927 | 14 | 0 | 16 | |
| GSE43470 | BRAT1 | 221927 | 7 | 2 | 34 | |
| GSE46452 | BRAT1 | 221927 | 13 | 1 | 45 | |
| GSE47630 | BRAT1 | 221927 | 10 | 1 | 29 | |
| GSE54993 | BRAT1 | 221927 | 0 | 7 | 63 | |
| GSE54994 | BRAT1 | 221927 | 21 | 2 | 30 | |
| GSE60625 | BRAT1 | 221927 | 0 | 0 | 11 | |
| GSE74703 | BRAT1 | 221927 | 7 | 1 | 28 | |
| GSE74704 | BRAT1 | 221927 | 9 | 0 | 11 | |
| TCGA | BRAT1 | 221927 | 56 | 5 | 35 |
Total number of gains: 151; Total number of losses: 19; Total Number of normals: 318.
Somatic mutations of BRAT1:
Generating mutation plots.
Highly correlated genes for BRAT1:
Showing top 20/1898 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRAT1 | OSR2 | 0.83468 | 3 | 0 | 3 |
| BRAT1 | KHSRP | 0.806402 | 4 | 0 | 4 |
| BRAT1 | RILPL2 | 0.793765 | 3 | 0 | 3 |
| BRAT1 | FYN | 0.792987 | 3 | 0 | 3 |
| BRAT1 | SSBP4 | 0.783631 | 4 | 0 | 4 |
| BRAT1 | CENPT | 0.782464 | 3 | 0 | 3 |
| BRAT1 | LRP12 | 0.776733 | 7 | 0 | 7 |
| BRAT1 | ALKBH6 | 0.775972 | 5 | 0 | 5 |
| BRAT1 | VPS13C | 0.775233 | 3 | 0 | 3 |
| BRAT1 | LAPTM4B | 0.774839 | 7 | 0 | 7 |
| BRAT1 | LTBR | 0.773876 | 4 | 0 | 4 |
| BRAT1 | RTKN | 0.772932 | 7 | 0 | 7 |
| BRAT1 | ZNF628 | 0.772252 | 3 | 0 | 3 |
| BRAT1 | TMEM184B | 0.771004 | 7 | 0 | 7 |
| BRAT1 | UCP2 | 0.770107 | 3 | 0 | 3 |
| BRAT1 | AGRN | 0.768679 | 7 | 0 | 7 |
| BRAT1 | NGF | 0.762911 | 3 | 0 | 3 |
| BRAT1 | IPO9 | 0.762022 | 4 | 0 | 4 |
| BRAT1 | KRTCAP2 | 0.760865 | 5 | 0 | 5 |
| BRAT1 | CERS2 | 0.758635 | 5 | 0 | 5 |
For details and further investigation, click here
