CRYGD

 

Full name: crystallin gamma D Alias Symbol: 
Type: protein-coding gene Cytoband: 2q33.3
Entrez ID: 1421 HGNC ID: HGNC:2411 Ensembl Gene: ENSG00000118231 OMIM ID: 123690
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CRYGD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CRYGD 1421 207532_at 0.0082 0.9826
GSE20347 CRYGD 1421 207532_at -0.0020 0.9798
GSE23400 CRYGD 1421 207532_at -0.0933 0.0007
GSE26886 CRYGD 1421 207532_at 0.0625 0.6126
GSE29001 CRYGD 1421 207532_at -0.2760 0.0934
GSE38129 CRYGD 1421 207532_at -0.1258 0.0912
GSE45670 CRYGD 1421 207532_at -0.0487 0.5234
GSE53622 CRYGD 1421 50145 0.1627 0.2177
GSE53624 CRYGD 1421 50145 0.1318 0.0417
GSE63941 CRYGD 1421 207532_at 0.2112 0.1928
GSE77861 CRYGD 1421 207532_at -0.1286 0.1652
GSE97050 CRYGD 1421 A_23_P131215 0.0964 0.7370

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by CRYGD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of CRYGD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CRYGD 1421 3 10 17
GSE20123 CRYGD 1421 3 10 17
GSE43470 CRYGD 1421 2 4 37
GSE46452 CRYGD 1421 1 4 54
GSE47630 CRYGD 1421 4 5 31
GSE54993 CRYGD 1421 0 3 67
GSE54994 CRYGD 1421 9 9 35
GSE60625 CRYGD 1421 0 3 8
GSE74703 CRYGD 1421 2 3 31
GSE74704 CRYGD 1421 2 5 13
TCGA CRYGD 1421 15 20 61

Total number of gains: 41; Total number of losses: 76; Total Number of normals: 371.  


 

Somatic mutations of CRYGD:

 

Generating mutation plots.

 

Highly correlated genes for CRYGD:

 

Showing top 20/596 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CRYGDC11orf680.704172303
CRYGDCHCHD50.667555303
CRYGDSNX150.658612303
CRYGDGDF30.658419505
CRYGDNLRP90.656807303
CRYGDC2orf160.65642303
CRYGDCA5B0.654179404
CRYGDPON10.653797303
CRYGDDEDD20.650985303
CRYGDE2F40.646595705
CRYGDSCN10A0.645758403
CRYGDARHGDIA0.64498303
CRYGDRGSL10.644619303
CRYGDSYT50.639684303
CRYGDCRISP10.638583504
CRYGDJAK30.638227605
CRYGDCBL0.63695403
CRYGDCIDEC0.636653403
CRYGDSPTAN10.636177403
CRYGDTSGA130.635734403

For details and further investigation, click here