| Full name: paraoxonase 1 | Alias Symbol: ESA | ||
| Type: protein-coding gene | Cytoband: 7q21.3 | ||
| Entrez ID: 5444 | HGNC ID: HGNC:9204 | Ensembl Gene: ENSG00000005421 | OMIM ID: 168820 |
| Drug and gene relationship at DGIdb | |||
Expression of PON1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PON1 | 5444 | 206345_s_at | -0.0966 | 0.7264 | |
| GSE20347 | PON1 | 5444 | 206345_s_at | 0.0476 | 0.4770 | |
| GSE23400 | PON1 | 5444 | 206345_s_at | -0.0841 | 0.0579 | |
| GSE26886 | PON1 | 5444 | 206345_s_at | -0.1062 | 0.4011 | |
| GSE29001 | PON1 | 5444 | 206345_s_at | -0.0992 | 0.5532 | |
| GSE38129 | PON1 | 5444 | 206345_s_at | 0.0261 | 0.8272 | |
| GSE45670 | PON1 | 5444 | 206344_at | 0.0370 | 0.7485 | |
| GSE53622 | PON1 | 5444 | 80944 | 0.0780 | 0.6610 | |
| GSE53624 | PON1 | 5444 | 80944 | -0.4105 | 0.0001 | |
| GSE63941 | PON1 | 5444 | 206345_s_at | -0.0142 | 0.9467 | |
| GSE77861 | PON1 | 5444 | 206345_s_at | -0.1304 | 0.2673 | |
| TCGA | PON1 | 5444 | RNAseq | 1.3830 | 0.2414 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PON1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PON1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PON1 | 5444 | 13 | 0 | 17 | |
| GSE20123 | PON1 | 5444 | 13 | 0 | 17 | |
| GSE43470 | PON1 | 5444 | 7 | 1 | 35 | |
| GSE46452 | PON1 | 5444 | 12 | 0 | 47 | |
| GSE47630 | PON1 | 5444 | 8 | 2 | 30 | |
| GSE54993 | PON1 | 5444 | 1 | 9 | 60 | |
| GSE54994 | PON1 | 5444 | 16 | 2 | 35 | |
| GSE60625 | PON1 | 5444 | 0 | 5 | 6 | |
| GSE74703 | PON1 | 5444 | 6 | 1 | 29 | |
| GSE74704 | PON1 | 5444 | 9 | 0 | 11 | |
| TCGA | PON1 | 5444 | 56 | 4 | 36 |
Total number of gains: 141; Total number of losses: 24; Total Number of normals: 323.
Somatic mutations of PON1:
Generating mutation plots.
Highly correlated genes for PON1:
Showing top 20/440 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PON1 | RBFADN | 0.696472 | 3 | 0 | 3 |
| PON1 | KCNN1 | 0.691244 | 4 | 0 | 4 |
| PON1 | GPD1 | 0.690742 | 4 | 0 | 4 |
| PON1 | CDH18 | 0.685069 | 4 | 0 | 3 |
| PON1 | IFT122 | 0.684932 | 3 | 0 | 3 |
| PON1 | LINC01192 | 0.673216 | 3 | 0 | 3 |
| PON1 | CRYGD | 0.653797 | 3 | 0 | 3 |
| PON1 | SCGN | 0.648928 | 4 | 0 | 4 |
| PON1 | LCT | 0.641216 | 6 | 0 | 6 |
| PON1 | GUCA1B | 0.640539 | 3 | 0 | 3 |
| PON1 | PLA2G6 | 0.634898 | 5 | 0 | 5 |
| PON1 | MOSPD3 | 0.633938 | 4 | 0 | 4 |
| PON1 | DMWD | 0.631231 | 4 | 0 | 4 |
| PON1 | SERPINA5 | 0.626334 | 3 | 0 | 3 |
| PON1 | OPHN1 | 0.626072 | 3 | 0 | 3 |
| PON1 | OR7C2 | 0.625985 | 3 | 0 | 3 |
| PON1 | SIRT3 | 0.625825 | 5 | 0 | 5 |
| PON1 | CHGA | 0.625022 | 3 | 0 | 3 |
| PON1 | MTTP | 0.624941 | 3 | 0 | 3 |
| PON1 | GPR22 | 0.623176 | 4 | 0 | 4 |
For details and further investigation, click here
